Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
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Structure & Function <strong>of</strong> (R)-(-)-Apomorphine• (R)-(-)-Apomorphine is a potent non-selectiveD 1 /D 2 agonist at the dopamine receptor.• (R)-(-)- Apomorphine (Apokyn) is used tocontrol Parkinson’s disease (D 2 receptor).• (R)-(-)- Apomorphine (Uprima ® ) is used to treaterectile dysfunction (D 1 receptor).• Features:• Contains an ortho-phenol motif.• Tetracyclic carbon skeleton.• Tetrahydroisoquinoline nucleus.• ‘Planar’ structure.• Contains an embedded dopaminepharmacophore.SR
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