Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
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CarboxylationBrOH1. NaH / DMFBrOOn-BuLi/HexaneLiOOCl2. MOM-ClCl(1) (2)THF-78 o C, 20 minsCllithiated intermediateHOOBa 14 CO 3c H 2SO 4<strong>14C</strong>O 2[ 14 C]-3-196 o C to rt>50 mCi/mmol250 mCiRadiochemical yield = 76%*OOCl