Understanding and Treating Acute Coronary Syndrome - FreeCE
Understanding and Treating Acute Coronary Syndrome - FreeCE
Understanding and Treating Acute Coronary Syndrome - FreeCE
- No tags were found...
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Page 2<strong>Underst<strong>and</strong>ing</strong> <strong>and</strong> <strong>Treating</strong> <strong>Acute</strong> <strong>Coronary</strong> <strong>Syndrome</strong>© 2010 Pharmaceutical Education Consultants, Inc. unless otherwise noted. All rights reserved.Reproduction in whole or in part without permission is prohibited.Definitions• Unstable Angina• An ↑ in frequency <strong>and</strong> duration of ischemicepisodes caused by an imbalance of O 2 supply<strong>and</strong> dem<strong>and</strong> due to a non-occlusive thrombus• Myocardial Infarction• Irreversible tissue necrosis caused by an occlusivethrombusDefinition• <strong>Acute</strong> <strong>Coronary</strong> <strong>Syndrome</strong> (ACS)• Patients present with acute chest pain <strong>and</strong> other signs orsymptoms suggestive of myocardial ischemia.• Often not possible to determine whether the patient has orwill sustain permanent damage to the myocardium(necrosis or AMI) or has reversible ischemia (UnstableAngina).• In retrospect, after either serial ECG changes <strong>and</strong>/or serialserum markers of myocardial injury, can this distinctionbetween AMI <strong>and</strong> UA be made.• ACS is a useful concept because the triage, assessment,<strong>and</strong> initial management of UA <strong>and</strong> AMI are similar.56PathophysiologyPathophysiology• CAD atherosclerotic heart disease• Plaque rupture• Initiation of clotting cascade• Release of vasoactive substances(epinephrine, thromboxane A 2 , ADP,thrombin, etc)• Thrombus formation• Myocardial O 2 dem<strong>and</strong> > Myocardial O 2supply7 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cardio&part=A1968
Change language