Medical Aspects of Chemical Warfare (2008) - The Black Vault

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Cyanide Poisoning226. Chen KK, Rose CL, Clowes GHA. Cyanide poisoning and its treatment. J Am Pharm Assoc. 1935;24:625–630.227. Baskin SI, Fricke. The pharmacology of p-aminopropiophenone in the detoxification of cyanide. Cardiovasc Drug Rev.1992;10:358–375.228. Kiese M, Weger N. Formation of ferrihaemoglobin with aminophenols in the human for the treatment of cyanidepoisoning. Eur J Pharmacol. 1969;7:97–105.229. Weiss S, Wilkins RW, Hayes FW. The nature of circulatory collapse induced by sodium nitrite. J Clin Invest. 1937;1673–1684.230. Sherman CR, MD. Medical director, Hope Pharmaceuticals Inc, Scottsdale, Ariz. Personal communication with amylnitrite drug supplier, October 2006.231. Lorcher W, Weger N. Optimal concentration of ferrihemoglobin for the treatment of cyanide poisoning. NaunynSchmiedeberg’s Arch Exp Pathol Pharmakol. 1971;270:R88.232. Szinicz L, Weger N, Schneiderhan W, Kiese M. Nephrotoxicity of aminophenols: effects of 4-dimethylaminophenolon isolated rat kidney tubules. Arch Toxicol. 1979;42:63–73.233. Morocco AP. Cyanides. Crit Care Clin. 2005;21:691–705.234. Szinicz L, Weger N, Schneiderhan W, Kiese M. Nephrotoxicity of aminophenols: effects of 4-dimethylaminophenolon isolated rat kidney tubules. Arch Toxicol. 1979;42:63–73.235. Kerger H, Dodidou P, Passani-Kruppa D, et al. Excessive methaemoglobinemia and multi-organ failure following4-DMAP antidote therapy. Resuscitation. 2005;66:231–235.236. Vandenbelt JM, Pfeiffer C, Kaiser M, Sibert M. Methemoglobinemia after administration of p-aminoacetophenone andp-aminopropiophenone. J Pharmacol Exp Ther. 1944;80:31–38.237. Bodansky O, Guttman H. Treatment of methemoglobinemia. J Pharmacol Exp Ther. 1947;90:46–56.238. Jandorf BJ, Bodansky O. Therapeutic and prophylactic effect of methemoglobinemia in inhalation poisoning by hydrogencyanide and cyanogen chloride. J Ind Hyg Toxicol. 1946;28:125–132.239. Tepperman J, Bodansky O. The role of hepatic detoxification in p-aminopropiophenone induced methemoglobinemia.J Pharmacol Exp Ther. 1946;88:287–299.240. Beutler E, Mikus BJ. The effect of sodium nitrite and para-aminopropiophenone administration on blood methemoglobinlevels and red blood cell survival. Blood. 1961;18:455–467.241. Bright JE. A prophylaxis for cyanide poisoning In: Ballantyne B, Marrs TC, eds. Clinical and Experimental Toxicology ofCyanides. Bristol, England: Wright; 1987: 359–382.242. Eckstein M. Cyanide as a chemical terrorism weapon. JEMS. 2004;29:22–31.243. Forsyth JC, Mueller PD, Becker CE, et al. Hydroxocobalamin as a cyanide antidote: safety, efficacy and pharmacokineticsin heavily smoking normal volunteers. J Toxicol Clin Toxicol. 1993;31:277–294.244. Hall AH, Rumack BH. Hydroxyocobalamin/sodium thiosulfate as a cyanide antidote. J Emerg Med. 1987;5:115–121.245. Rotenberg JS. Cyanide as a weapon of terror. Pediatr Ann. 2003;32:236–240.246. Sauer SW, Keim ME. Hydroxocobalamin: improved public health readiness for cyanide disasters. Ann Emerg Med.2001;37:635–641.409
Medical Aspects of Chemical Warfare247. Astier A, Baud FJ. Complexation of intracellular cyanide by hydroxocobalamin using a human cellular model. HumExp Toxicol. 1996;15:19–25.248. Borron SW, Baud FJ. Acute cyanide poisoning: clinical spectrum, diagnosis, and treatment. Arh Hig Rada Toksikol.1996;47:307–322.249. Baud FJ, Department of Medical and Toxicological Critical Care, Lariboisiere Hospital, Paris, France. Personal communication,January 2005.250. DesLauriers CA, Burda AM, Wahl M. Hydroxocobalamin as a cyanide antidote. Am J Ther. 2006;13:161–165.251. Marrs TC. Dicobalt edetate (Kelocyanor). In: Meredith TH, Jacobsen D, Haines JA, Berger J-C, van Heijst ANP, eds.Anitdotes for Poisoning by Cyanide. Vol 2. In: International Program on Chemical Safety/Commission of the European CommunitiesEvaluation of Antidotes Series. Geneva, Switzerland: World Health Organization and Commission of the EuropeanCommunities; 1993: 79–94. Publication EUR 14280 EN.252. Rose CL, Worth RM, Kikuchi K, Chen KK. Cobalt salts in acute cyanide poisoning. Proc Soc Exp Biol Med. 1965;120:780–783.410
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The Coat of Arms1818Medical Departm
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Textbooks of Military MedicinePubli
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MEDICAL ASPECTS o fCHEMICAL WARFARE
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ContentsContributorsForeword by The
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ContributorsMICHAEL ADLER, PhDResea
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DONALD M. MAXWELL, MSResearch Chemi
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ForewordThe US military has been co
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PrefaceA significant concern for th
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PrologueThe original edition of Med
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xxii
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Medical Aspects of Chemical Warfare
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Nerve AgentsChapter 5NERVE AGENTSFR
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Nerve AgentsAbout 10,000 to 30,000
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Nerve Agentsphorofluoridate (DFP) w
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Nerve AgentsFig. 5-2. This schemati
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Nerve AgentsExhibit 5-1 continuedis
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Nerve Agentsactivity but only 15% t
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Nerve AgentsTABLE 5-3CHEMICAL, PHYS
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Nerve AgentsTABLE 5-4EFFECTS OF EXP
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Nerve Agentsaffecting the other eye
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Nerve Agentsmay cause severe rhinor
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Nerve Agentsof jerks and tremor.Cen
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Nerve Agentsand they were decreased
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Nerve Agentsnerve agent toxicity on
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Nerve Agentspatient. Decontaminatio
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Nerve AgentsFig. 5-5. The Mark I ki
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Nerve Agentsadministered intramuscu
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Nerve Agentsthat hydroxamine reacti
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Nerve AgentsOral administration may
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Nerve AgentsTABLE 5-7RECOMMENDED TH
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Nerve Agentsimpairment such as whee
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Nerve Agentssuboptimal, manner. The
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Nerve Agentsthan those who did not.
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Nerve Agentssible for binding nerve
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Nerve Agentsfor comparison was not
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Nerve AgentsTABLE 5-11EFFECTS OF PY
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Nerve Agentstivity of smooth muscle
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Nerve Agents38. Grob D, Lilienthal
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Nerve Agents77. McDonough JH, Shih
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Nerve Agents117. McLeod CG Jr, Sing
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Nerve Agents154. Tryphonas l, Veino
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Nerve Agents193. Funckes AJ. Treatm
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Nerve Agents235. Suzuki T, Morita H
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Nerve Agents274. Pellegrini JE, Bak
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PROCESSMedical Aspects of Chemical
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Page 381 and 382: Medical Aspects of Chemical Warfare
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Triage of Chemical CasualtiesChapte
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Triage of Chemical Casualtiesreceiv
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Triage of Chemical Casualtiesentran
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Triage of Chemical Casualtiescatego
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Triage of Chemical CasualtiesIn a f
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Triage of Chemical Casualtiesnose)
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Triage of Chemical CasualtiesWith n
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Triage of Chemical Casualties14. Sa
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Decontamination of Chemical Casualt
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• Analyze using GC-MS with methan
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Abbreviations and AcronymsAbBreviat
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Abbreviations and AcronymsPADPRP: p
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