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Vesicants141. Barillo DJ, McManus AT, Cancio LC, Sofer A, Goodwin CW. Burn center management of necrotizing fasciitis. J BurnCare Rehabil. 2003;24:127–132.142. Mendelson JA, Lindsey D. Sulfamylon (mafenide) and penicillin as expedient treatment of experimental massive openwounds with C. perfringens infection. J Trauma. 1962;2:239–261.143. Mendelson JA. Topical mafenide hydrochloride aqueous spray in initial management of massive contaminated woundswith devitalized tissue. Prehospital Disaster Med. 2001;16:172–174.144. Mendelson JA. The management of burns under conditions of limited resources using topical aqueous sulfamylon(mafenide) hydrochloride spray. J Burn Care Rehabil. 1997;18:238–244.145. Mendelson JA, Pratt HJ, Amato JJ, et al. Mafenide hydrochloride and mafenide acetate in spray and ointment formsas topical therapy C Perfringins contaminated massive wounds: experimental study. J Trauma. 1970;10:1132–1144.146. Smith WJ, Babin MC, Kiser RC, Casillas RP. Development of medical countermeasures to sulfur mustard vesication.In: Salem H, Katz SA, eds. Alternative Toxicological Methods. Boca Raton, Fla: CRC Press; 2003: 323–328.147. Babin MC, Ricketts K, Skvorak JP, Gazaway M, Mitcheltree LW, Casillas RP. Systemic administration of candidateantivesicants to protect against topically applied sulfur mustard in the mouse ear vesicant model (MEVM). J ApplToxicol. 2000;20:S141–S144.148. Casillas RP, Kiser RC, Truxall JA, et al. Therapeutic approaches to dermatotoxicity by sulfur mustard. I. Modulationof sulfur mustard-induced cutaneous injury in the mouse ear vesicant model. J Appl Toxicol. 2000;20:S145–S151.149. Amir A, Chapman S, Kadar T, Gozes Y, Sahar R, Allon N. Sulfur mustard toxicity in macrophages: effect of dexamethasone.J Appl Toxicol. 2000;20:S51–S58.150. Amir A, Turetz J, Chapman S, et al. Beneficial effects of topical anti-inflammatory drugs against sulfur-mustard-inducedocular lesions in rabbits. J Appl Toxicol. 2000;20:S109–S114.151. Husain K, Dube SN, Sugendran K, Singh R, Das Gupta S, Somani HD. Effect of topically applied sulphur mustard onantioxidant enzymes in blood cells and body tissues of rats. J Appl Toxicol. 1996;16(3):245–248.152. Kumar O, Sugendran K, Vijayaraghavan R. Protective effect of various antioxidants on the toxicity of sulphur mustardadministered to mice by inhalation or percutaneous routes. Chem Biol Interact. 2001;134(1):1–12.153. Naghii MR. Sulfur mustard intoxication, oxidative stress and antioxidants. Mil Med. 2002;167(7):573–575.154. Helfman T, Ovington L, Falanga V. Occlusive dressings and wound healing. Clin Dermatol. 1994;12(1):121–127.155. Chang H, Wind S, Kerstein MD. Moist wound healing. Dermatol Nurs. 1996;8(3):174–176.156. Kerstein MD. Moist wound healing: the clinical perspective. Ostomy Wound Manage. 1995;41(7A Suppl):37S–44S.157. Field CK, Kerstein MD. Overview of wound healing in a moist environment. Am J Surg. 1994;167(1A):2S–6S.158. Logan TP, Graham JS, Martin JL, Zallnick JE, Jakubowski EM, Braue EH. Detection and measurement of sulfur mustard(HD) offgassing from the weanling pig following exposure to saturated sulfur mustard vapor. J Appl Toxicol.2000;20:S199–204.159. Marsden AK. Accident department. In: Settle JAD, ed. Principles and Practice of Burns Management. New York, NY:Churchill Livingstone, 1996: 209–215.160. Johnson RM, Richard R. Partial-thickness burns: identification and management. Adv Skin Wound Care. 2003;6(4):178–189.303
Medical Aspects of Chemical Warfare161. Arturson G. Mechanism of injury. In: Settle JAD, ed. Principles and Practice of Burns Management. New York, NY:Churchill Livingstone, 1996: 61–82.162. Brown RFR, Rice P, Bennett NJ. The use of laser Doppler imaging as an aid in clinical management decision makingin the treatment of vesicant burns. Burns. 1998; 24(8):692–698.163. Chilcott RP, Brown RFR, Rice P. Non-invasive quantification of skin injury resulting from exposure to sulphur mustardand Lewisite vapours. Burns. 2000;26(3):245–250.164. Green HA, Bua D, Anderson RR, Nishioka NS. Burn depth estimation using indocyanine green fluorescence. ArchDermatol. 1992;128:43–49.165. Black KS, Hewitt CW, Miller DM, et al. Burn depth evaluation with fluorometry: is it really definitive? J Burn CareRehabil. 1986;7(4):313–317.166. Schomacker KT, Torri A, Sandison DR, Sheridan RL, Nishioka NS. Biodistribution of indocyanine green in a porcineburn model: light and fluorescence microscopy. J Trauma. 1997;43:813–819.167. Jerath MR, Schomacker KT, Sheridan RL, Nishioka NS. Burn wound assessment in porcine skin using indocyaninegreen fluorescence. J Trauma. 1999;46(6):1085–1088.168. Holm C, Mayr M, Tegeler J, Becker A, Pfeiffer U, Muhlbauer W. Laser-induced fluorescence of indocyanine green:plastic surgical applications. Eur J Plast Surg. 2003;26:19–25.169. Holm C, Mayr M, Hofter E, Becker A, Pfeiffer UJ, Muhlbauer W. Intraoperative evaluation of skin-flap viability usinglaser-induced fluorescence of indocyanine green. Br J Plast Surg. 2002;55(8):635–644.170. Sheridan RL, Schomacker KT, Lucchina LC, et al. Burn depth estimation by use of indocyanine green fluorescence:initial human trial. J Burn Care Rehabil. 1995;16(6):602–604.171. Braue EH, Graham JS, Doxzon BF, et al. Non-invasive methods for determining lesion depth from vesicant exposure.J Burn Care Res. 2007;28(2):275–285.172. Graham JS, Schomacker KT, Glatter RD, Briscoe CM, Braue EH, Squibb KS. Efficacy of laser debridement with autologoussplit-thickness skin grafting in promoting improved healing of deep cutaneous sulfur mustard burns. Burns.2002;28(8):719–730.173. Graham JS, Schomacker KT, Glatter RD, Briscoe CM, Braue EH Jr, Squibb KS. Bioengineering methods employed inthe study of wound healing of sulfur mustard burns. Skin Res Technol. 2002;8(1):57–69.174. Rice P. The use of dermabrasion to accelerate the naturally slow rate of epidermal healing mustard injuries in pigs. In:Proceedings of the 1995 NATO Research Study Group 3 Meeting on Prophylaxis and Therapy Against Chemical Agents, PortonDown, Salisbury, England, 18–21 September 1995. Porton Down, Salisbury, England: Chemical and Biological DefenceEstablishment, 1995. CTIC No. AD-B209142.175. Rice P, Brown RFR, Lam DGK, Chilcott RP, Bennett NJ. Dermabrasion—a novel concept in the surgical managementof sulphur mustard injuries. Burns. 2000;26(1):34–40.176. Rice P, Bennett NJ, Lam DGK, Brown RFR. The role of dermabrasion in Lewisite-induced skin injury. In: Proceedingsof the 2000 Medical Defense Bioscience Review, Hunt Valley, Md, 4–9 June 2000. Aberdeen Proving Ground, Md: US ArmyMedical Research Institute of Chemical Defense; 2000: 1179–1186.177. Kjellstrom BT, Persson JK, Runn P. Surgical treatment of skin lesions induced by sulfur mustard (“mustard gas”)—anexperimental study in the guinea pig. Ann Acad Med Singapore. 1997;26(1):30–36.178. Lam DG, Rice P, Brown RF. The treatment of Lewisite burns with laser debridement—‘lasablation.’ Burns. 2002;28(1):19–25.304
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MEDICAL ASPECTS o fCHEMICAL WARFARE
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ContentsContributorsForeword by The
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ContributorsMICHAEL ADLER, PhDResea
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DONALD M. MAXWELL, MSResearch Chemi
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ForewordThe US military has been co
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Nerve AgentsChapter 5NERVE AGENTSFR
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Nerve AgentsAbout 10,000 to 30,000
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Nerve Agentsaffecting the other eye
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• Analyze using GC-MS with methan
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Abbreviations and AcronymsAbBreviat
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Abbreviations and AcronymsPADPRP: p
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