Medical Aspects of Chemical Warfare (2008) - The Black Vault

Medical Aspects of Chemical Warfare (2008) - The Black Vault Medical Aspects of Chemical Warfare (2008) - The Black Vault

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Introduction to the Chemical ThreatTHE role of the US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSEUSAMRICD is the lead Department of Defense laboratorydealing with the medical aspects of chemicaldefense. It focuses on medical research, training, andeducation for medical chemical defense. USAMRICDactivity involves basic research, clinical studies, therapeutics,and other areas of research. USAMRICD alsopartners with major military and civilian organizationsthroughout the country and abroad.Development of Medical CountermeasuresUSAMRICD builds on basic research to supportsoldiers through the development of medical countermeasuresand therapeutics. Current projects includethe use of both simple and catalytic bioscavengers forprophylaxis and treatment of nerve agent casualties.Additional research areas of interest include the newoximes and neuroprotective compounds that mitigatethe effects of nerve agent exposure. Studies investigatingthe use of midazolam as a new generation nerveanticonvulsant are in advanced stages. There is anincrease in medical vesicant research to indentify thespecific biochemistry of injury as well as to developnovel protectants and treatments. Cyanide and pulmonaryagent research has been increasing in pace aswell. Other work at USAMRICD involves developingmedical diagnostics and personnel decontaminationresearch. Work on equipment and detection gear isconducted by USAMRICD’s partner institute, theEdgewood Chemical Biological Center.Education and Educational ProductsThe chemical casualty care division is responsiblefor training military medical personnel in the practiceof medical defense, medical decontamination, andtriage. It also provides education for other militarybranches, civilians, government agencies, and foreignnationals. Courses are accredited as continuing medicaleducation for physicians, nurses, and emergencymedical technicians, and for college credit.The courses taught onsite at the chemical casualtycare division include the Medical Management ofChemical and Biological Casualties Course, whichis produced jointly with the US Army Medical ResearchInstitute of Infectious Diseases. The courseconsists of lectures, a field exercise, and a uniqueprimate lab experience. It has been recognized asthe gold standard for this type of training by theOffice of The Surgeon General and the GovernmentAccountability Office. Other courses includethe Field Management of Chemical and BiologicalCasualties, which targets front echelon care. Thiscourse includes multiple field exercises to encourageproficiency in the field medical decontaminationstation. The Hospital Management of Chemical BiologicalRadiological Nuclear and Explosives Courseis a preparatory course for mass casualty chemical,biological, radiological, nuclear, and explosivesevents. It includes instruction on regulations regardingthese events and cooperation with civilian andmilitary authorities at other echelons.The chemical casualty care division is responsiblefor a large volume of educational products. Theseproducts include publication content for educationalmaterials as well as pocket manuals for the fieldmanagement of chemical casualties and medicalmanagement of chemical casualties. The chemicalcasualty care division produces several softwareproducts, such as reference materials, distance andonline training courses, educational games, and interactivesimulations.ORGANIZATION OF THIS VOLUMEAwareness and interest in weapons of mass destruction,medical chemical defense research, and educationand training of military personnel and civilians has increaseddramatically in the last few years. The need foran updated and resultant text dedicated to the medicalaspects of biological and chemical weapons would notfit into a single textbook. Hence, this text differs fromthe earlier version of the Textbooks of Military Medicine:Medical Aspects of Chemical and Biological Warfarebecause biological and chemical agents are discussedin separate volumes. This text is primarily relevantto military medicine; however, due to the increasedinterest in chemical casualty treatment that now existswithin civilian communities, the information providedwithin this text can be considered an excellent resourcefor both military and civilian healthcare providers.Chapters 2 through 4 offer greater depth concerningthe history of chemical warfare and the basic principlesof chemical warfare. “History of Chemical Warfare”takes a broad view of the historical context and significantevents in the field. “History of the ChemicalThreat” breaks the 20th century down into decade-longsegments and provides a fresh perspective on priormilitary and political developments. “The MedicalAspects of Medical Management” chapter has radicallychanged over the years and presents this history frommultiple perspectives. It includes detailed accountsof the chemical warfare management experience in5

Medical Aspects of Chemical Warfarethe United States, as well as a revealing explorationof British, Canadian, French, Russian, and Germanexperiences.Chapters 5 through 7 concentrate on nerve agents.Chapter 5 is a comprehensive treatise on the presentresearch, countermeasures, physiology, and managementof nerve agent casualties. The chapter on neuroprotection(Chapter 6), new to this volume, reviewsdevelopments in protective adjuncts to classic nerveagent antidote therapy. Chapter 7, also new, examinesthe emerging field of therapeutics that may representthe next advancement in therapy for these casualties.Chapters 8 through 15 cover the remaining categoriesof threat agents. Vesicants are presented in historical,clinical, and physiological detail in Chapter 8, andChapter 9 has been updated with the most current clinicaldata in the field. Given the increased nonstate andterrorist threat from chemical weapons, the chapter ontoxic industrial chemicals has been broadened (Chapter10). Cyanide appears to be of major interest to terroristsand the civilian population, so Chapter 11 has beenexpanded in size and scope. Two chapters devoted tononlethal agents are also covered in this section.Chapters 16 through 19 are concerned with thefield management, triage, and decontaminationprocedures within the US military. Current and newequipment are described in detail. The final sectionof the book relates to partnering, acquisition, andpreparedness and includes an entirely new chapterdedicated to the medical management of pediatriccasualties. There is also a chapter devoted to medicaldiagnostics (Chapter 22).SUMMARYThe chemical warfare threat to the United States haschanged dramatically in recent years, becoming less obscure.Chemical weapons that are being destroyed underthe Chemical Warfare Convention by major nation-states are increasingly attractive to pariah states andterrorists. In the current environment, the United Statesmay experience a higher likelihood of a chemical attackon its military forces and civilian population, more sothan ever before in the history of chemical warfareand terrorism.Given the changing chemical threat, this textbookhas broadened in scope and depth and now encompassesan entire volume. This expanded text attemptsto be a comprehensive guide to the full spectrum ofthese agents and to provide information on the stateof the art in medical therapeutics.REFERENCES1. Tucker Jonathan B. War of Nerves: Chemical Warfare from World War I to Al-Qaeda. New York, NY: Pantheon Books; 2006: 245.2. Englund W. Ex-Soviet scientist says Gorbachev’s regime created new nerve gas in ’91. Baltimore Sun. September 16,1992:3A.3. Englund W. Russia still doing secret work on chemical arms. Research goes on as government seeks U.N. ban. BaltimoreSun. October 18, 1992:1A.4. Smithson AE, Mirzayanov VS, Lajoie R, Krepon M. Chemical Weapons Disarmament in Russia: Problems and Prospects.Washington, DC: Henry L. Stimson Center; October 1995. Report No. 17.5. The United States Department of State, Bureau of International Security and Nonproliferation, and the United StatesDepartment of Commerce, Bureau of Industry and Security. The United States Chemical Weapons Convention Website. Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons andon their Destruction. Available at: http://www.cwc.gov. Accessed June 12, 2007.6. United States Office of the Assistant Secretary of Defense, “Chemical weapons stockpile information declassified,”news release, January 22, 1996. Document 024-96.7. US Army. US Army Chemical Materials Agency Web site. Available at: http://www.pmcd.army.mil. Accessed December2006.8. Russian Munitions Agency Web site. Available at: http://www.munition.gov.ru/eng/zapasho.html. Accessed November2006.6

<strong>Medical</strong> <strong>Aspects</strong> <strong>of</strong> <strong>Chemical</strong> <strong>Warfare</strong>the United States, as well as a revealing exploration<strong>of</strong> British, Canadian, French, Russian, and Germanexperiences.Chapters 5 through 7 concentrate on nerve agents.Chapter 5 is a comprehensive treatise on the presentresearch, countermeasures, physiology, and management<strong>of</strong> nerve agent casualties. <strong>The</strong> chapter on neuroprotection(Chapter 6), new to this volume, reviewsdevelopments in protective adjuncts to classic nerveagent antidote therapy. Chapter 7, also new, examinesthe emerging field <strong>of</strong> therapeutics that may representthe next advancement in therapy for these casualties.Chapters 8 through 15 cover the remaining categories<strong>of</strong> threat agents. Vesicants are presented in historical,clinical, and physiological detail in Chapter 8, andChapter 9 has been updated with the most current clinicaldata in the field. Given the increased nonstate andterrorist threat from chemical weapons, the chapter ontoxic industrial chemicals has been broadened (Chapter10). Cyanide appears to be <strong>of</strong> major interest to terroristsand the civilian population, so Chapter 11 has beenexpanded in size and scope. Two chapters devoted tononlethal agents are also covered in this section.Chapters 16 through 19 are concerned with thefield management, triage, and decontaminationprocedures within the US military. Current and newequipment are described in detail. <strong>The</strong> final section<strong>of</strong> the book relates to partnering, acquisition, andpreparedness and includes an entirely new chapterdedicated to the medical management <strong>of</strong> pediatriccasualties. <strong>The</strong>re is also a chapter devoted to medicaldiagnostics (Chapter 22).SUMMARY<strong>The</strong> chemical warfare threat to the United States haschanged dramatically in recent years, becoming less obscure.<strong>Chemical</strong> weapons that are being destroyed underthe <strong>Chemical</strong> <strong>Warfare</strong> Convention by major nation-states are increasingly attractive to pariah states andterrorists. In the current environment, the United Statesmay experience a higher likelihood <strong>of</strong> a chemical attackon its military forces and civilian population, more sothan ever before in the history <strong>of</strong> chemical warfareand terrorism.Given the changing chemical threat, this textbookhas broadened in scope and depth and now encompassesan entire volume. This expanded text attemptsto be a comprehensive guide to the full spectrum <strong>of</strong>these agents and to provide information on the state<strong>of</strong> the art in medical therapeutics.REFERENCES1. Tucker Jonathan B. War <strong>of</strong> Nerves: <strong>Chemical</strong> <strong>Warfare</strong> from World War I to Al-Qaeda. New York, NY: Pantheon Books; 2006: 245.2. Englund W. Ex-Soviet scientist says Gorbachev’s regime created new nerve gas in ’91. Baltimore Sun. September 16,1992:3A.3. Englund W. Russia still doing secret work on chemical arms. Research goes on as government seeks U.N. ban. BaltimoreSun. October 18, 1992:1A.4. Smithson AE, Mirzayanov VS, Lajoie R, Krepon M. <strong>Chemical</strong> Weapons Disarmament in Russia: Problems and Prospects.Washington, DC: Henry L. Stimson Center; October 1995. Report No. 17.5. <strong>The</strong> United States Department <strong>of</strong> State, Bureau <strong>of</strong> International Security and Nonproliferation, and the United StatesDepartment <strong>of</strong> Commerce, Bureau <strong>of</strong> Industry and Security. <strong>The</strong> United States <strong>Chemical</strong> Weapons Convention Website. Convention on the Prohibition <strong>of</strong> the Development, Production, Stockpiling and Use <strong>of</strong> <strong>Chemical</strong> Weapons andon their Destruction. Available at: http://www.cwc.gov. Accessed June 12, 2007.6. United States Office <strong>of</strong> the Assistant Secretary <strong>of</strong> Defense, “<strong>Chemical</strong> weapons stockpile information declassified,”news release, January 22, 1996. Document 024-96.7. US Army. US Army <strong>Chemical</strong> Materials Agency Web site. Available at: http://www.pmcd.army.mil. Accessed December2006.8. Russian Munitions Agency Web site. Available at: http://www.munition.gov.ru/eng/zapasho.html. Accessed November2006.6

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