Medical Aspects of Chemical Warfare (2008) - The Black Vault

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Nerve Agents77. McDonough JH, Shih TM. Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology.Neurosci Biobehav Rev. 1997;21:559–579.78. Kawana N, Ishimatsu S, Kanda K. Psycho-physiological effects of the terrorist sarin attack on the Tokyo subwaysystem. Mil Med. 2001;166(12 suppl):23–26.79. Romano JA, McDonough JH, Sheridan R, Sidell FR. Health effects of low-level exposure to nerve agents. In: SomaniSM, Romano JA, eds. Chemical Warfare Agents: Toxicity at Low Levels. Boca Raton, Fla: CRC Press; 2001:1–24.80. McDonough JH. Performance impacts of nerve agents and their pharmacological countermeasures. Mil Psychol.2002;14(2):93-119.81. Brown EC Jr. Effects of G Agents on Man: Clinical Observations. Edgewood Arsenal, Md: Medical Laboratory; 1948.Medical Division Report 158.82. Craig AB Jr, Cornblath M. Further Clinical Observations in Workers Accidentally Exposed to G Agents. Edgewood Arsenal,Md: Medical Research Laboratory; 1953. Medical Laboratory Research Report 234.83. Brody BB, Gammill JF. Seventy-Five Cases of Accidental Nerve Gas Poisoning at Dugway Proving Ground. Dugway ProvingGround, Utah: Medical Investigational Branch; 1954. Medical Investigational Branch Special Report 5.84. Bowers MB, Goodman E, Sim VM. Some behavioral changes in man following anticholinesterase administration. JNerv Ment Dis. 1964;138:383–389.85. United Kingdom Ministry of Defence. Psychological effects of a G-agent on men. London, England: Ministry of Defence.Unpublished report.86. United Kingdom Ministry of Defence. Psychological effects of a G-agent on men: 2nd report. London, England: Ministryof Defence. Unpublished report.87. United Kingdom Ministry of Defence. The effects of a single exposure to GB (sarin) on human physical performance.London, England: Ministry of Defence. Unpublished report.88. United Kingdom Ministry of Defence. The effects of a minor exposure to GB on military efficiency. London, England:Ministry of Defence. Unpublished report.89. Brimblecombe RW, Buxton DA. Behavioural actions of anticholinergic drugs. Prog Brain Res. 1972;36:115–126.90. Voytko ML. Cognitive functions of the basal forebrain cholinergic system in monkeys: memory or attention? BehavBrain Res. 1996;75:13–25.91. Bartus RT, Dean RL 3rd, Beer B, Lippa AS. The cholinergic hypothesis of geriatric memory dysfunction. Science.1982;217:408–417.92. Davis KL, Berger PA, Hollister LE, Barchas JD. Cholinergic involvement in mental disorders. Life Sci. 1978;22:1865–1871.93. Janowsky DS, Risch SC, Gillin JC. Adrenergic-cholinergic balance and the treatment of affective disorders. Prog NeuropsychopharmacolBiol Psychiatry. 1983;7:297–307.94. Janowsky DS, Overstreet DH. Cholinergic dysfunction in depression. Pharmacol Toxicol. 1990;66(suppl 3):100–111.95. Baghdoyan HA, Monaco AP, Rodrigo-Angulo ML, Assens F, McCarley RW, Hobson JA. Microinjection of neostigmineinto the pontine reticular formation of cats enhances desynchronized sleep signs. J Pharmacol Exp Ther. 1984;231:173–180.96. George R, Haslett WL, Jenden DJ. A cholinergic mechanism in the brainstem reticular formation: induction of paradoxicalsleep. Int J Neuropharmacol. 1964;3:541–552.209
Medical Aspects of Chemical Warfare97. Gnadt JW, Pegram GV. Cholinergic brainstem mechanisms of REM sleep in the rat. Brain Res. 1986;384:29–41.98. Hobson JA. Sleep and dreaming: induction and mediation of REM sleep by cholinergic mechanisms. Curr Opin Neurobiol.1992;2:759–763.99. Gillin JC, Sitaram N, Mendelson WB, Wyatt RJ. Physostigmine alters onset but not duration of REM sleep in man.Psychopharmacol (Berl). 1978;58:111–114.100. Gnadt JW, Atwood CW, Meighen GA, Pegram GV. Di-isopropyl-fluorophosphate (DFP): acute toxicity and sleep.Neurotoxicology. 1986;7:165–171.101. Gnadt JW, Pegram GV, Baxter JF. The acetylcholinesterase inhibitor di-isopropyl-fluorophosphate increases REM sleepin rats. Physiol Behav. 1985;35:911–916.102. Sitaram N, Wyatt RJ, Dawson S, Gillin JG. REM sleep induction by physostigmine infusion during sleep. Science.1976;191:1281–1283.103. Grob D, Harvey AM, Langworthy OR, Lilienthal JL Jr. The administration of di-isopropyl fluorophosphate (DFP) toman, III: effect on the central nervous system with special reference to the electrical activity of the brain. Bull JohnsHopkins Hosp. 1947;81:257–266.104. Grob D. The manifestations and treatment of poisoning due to nerve gas and other organic phosphate anticholinesterasecompounds. AMA Arch Intern Med. 1956;98:221–239.105. Glenn JF, Hinman DJ, McMaster SB. Electroencephalographic correlates of nerve agent poisoning. In: Dun NJ, PerlmanL, eds. Neurobiology of Acetylcholine. New York, NY: Plenum Press; 1987:503–534.106. Koplovitz I, Skvorak JP. Electrocorticographic changes during generalized convulsive status epilepticus in somanintoxicated rats. Epilepsy Res. 1998;30:159–164.107. Shih TM, Duniho SM, McDonough JH. Control of nerve agent-induced seizures is critical for neuroprotection andsurvival. Toxicol Appl Pharmacol. 2003;188:69–80.108. Holmes JH, Gaon MD. Observations on acute and multiple exposure to anticholinesterase agents. Trans Am Clin ClimatolAssoc. 1956;68:86–101.109. Metcalf DR, Holmes JH. EEG, psychological, and neurological alterations in humans with organophosphorus exposure.Ann N Y Acad Sci. 1969;160:357–365.110. Sekijima Y, Morita H, Shindo M, Okudera H, Shibata T. A case of severe sarin poisoning in the sarin attack at Matsumoto—one-yearfollow-up on the clinical findings and laboratory data [in Japanese]. Rinsho Shinkeigaku [ClinicalNeurology]. 1995;35:1241–1245.111. Shih TM, Koviak TA, Capacio BR. Anticonvulsants for poisoning by the organophosphorus compound soman: pharmacologicalmechanisms. Neurosci Biobehav Rev. 1991;15:349–362.112. Levin HS, Rodnitzky RL. Behavioral effects of organophosphate pesticides in man. Clin Toxicol. 1976;9:391–403.113. Karczmar AG. Acute and long lasting central actions of organophosphorus agents. Fundam Appl Toxicol. 1984;4:S1–S17.114. Duffy FH, Burchfiel JL, Bartels PH, Gaon M, Sim VM. Long-term effects of an organophosphate upon the humanelectroencephalogram. Toxicol Appl Pharmacol. 1979;47:161–176.115. Petras JM. Soman neurotoxicity. Fundam Appl Toxicol. 1981;1:242.116. Lemercier G, Carpentier P, Sentenac-Roumanou H, Morelis P. Histological and histochemical changes in the centralnervous system of the rat poisoned by an irreversible anticholinesterase organophosphorus compound. Acta Neuropathol(Berl). 1983;61:123–129.210
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The Coat of Arms1818Medical Departm
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Textbooks of Military MedicinePubli
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MEDICAL ASPECTS o fCHEMICAL WARFARE
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ContentsContributorsForeword by The
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ContributorsMICHAEL ADLER, PhDResea
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DONALD M. MAXWELL, MSResearch Chemi
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ForewordThe US military has been co
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PrefaceA significant concern for th
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PrologueThe original edition of Med
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xxii
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Medical Aspects of Chemical Warfare
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Nerve AgentsChapter 5NERVE AGENTSFR
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Nerve AgentsAbout 10,000 to 30,000
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Page 198 and 199: Nerve Agentsof jerks and tremor.Cen
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Page 202 and 203: Nerve Agentsnerve agent toxicity on
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PROCESSMedical Aspects of Chemical
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Triage of Chemical CasualtiesChapte
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Triage of Chemical Casualtiesreceiv
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Triage of Chemical Casualtiesentran
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Triage of Chemical Casualtiescatego
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Triage of Chemical CasualtiesIn a f
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Triage of Chemical Casualtiesnose)
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Triage of Chemical CasualtiesWith n
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Triage of Chemical Casualties14. Sa
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Decontamination of Chemical Casualt
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• Analyze using GC-MS with methan
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Abbreviations and AcronymsAbBreviat
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Abbreviations and AcronymsPADPRP: p
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