Molecular Allergology.pdf - Phadia

You know it is allergy, but..Do you know how severe is it?Have you identified the true cause of sensitization?Is your patient optimally managed?

An allergen source…

…contains …of which thousands only aof few molecules… are allergenicAllergenic molecule = component

From allergen source to component

Components are proteins• Specific• Cross-reactive• Different stabilities• Different amountsProtein families based on homology

Specific components- indicate genuine sensitizationPeanutAra h 2Honey beeApi m 1EggGal d 1TimothyPhl p 1BirchBet v 1Gal d 1 = Gallus domesticus, allergen # 1

Cross-reactive componentsSoy, birch and peanut containcomponents with high similarity

Clinical consequencesSensitization to specific components:• Guides avoidance recommendations• Indicates Specific ImmunotherapySensitization to cross-reactive components only:• Suggest further investigation to find primary sensitizer

Risk assessment

Protein stabilityLabile proteinStable proteinLocal reactionSystemic reaction

Molecular Allergology helps you to• Assess the clinical risk for reaction• Explain symptoms due to cross-reactivity• Identify the right patients forSpecific Immunotherapy

Molecular Allergology improvesallergy diagnosis