SIOGENE SUSP. 170ml - Lomus Pharmaceuticals Pvt. Ltd.

SIOGEN SuspensionDosage Forms/CompositionSuspension: Each 10mL contains Magaldrate 800mg, Simethicone 50mg and Sodiumalginate 100mg.Pharmacological IndexAntacid. Acid neutraliserINDICATIONHyperacidity associated with the diagnosis of peptic ulcer, gastritis, reflux oesophagitis,and gastric hyperacidity.ContraindicationsHypersensitivity. Symptoms of appendicitis since Siogen may increase the danger ofperforation or rupture due to the constipating or laxative effects. Severe renal functionimpairment, hypophosphatemia. Do not use this product if you are presently taking aprescription antibiotic drug containing any form of tetracycline.Adverse ReactionsNausea, vomiting, metallic taste, constipation, diarrhoea, GI discomfort. Large doses cancause obstruction. Hypermagneseamia (renal function is impaired). Patients with lowphosphate diets may lead to phosphate depletion accompanied by increased resorptionand urinary excretion of calcium with the risk of osteomalacia. Osteomalacia,encephalopathy, hyperaluminemia and dementia have occurred in patients withchronic renal failure on high aluminium-dose as a phosphate-binding agent.Drug InteractionsIron, tetracycline, isoniazid, ethambutol, some anti-muscarinic drugs, benzodiazepines,phenothiazines, ranitidine, indomethacin, phenytoin, nitrofurantoin, vitamin A, fluorideand phosphate. Medications should not be taken within one to two hours of Siogen, ifpossible.Mechanism of ActionSiogen reacts chemically to neutralize or buffer existing quantities of stomach acid buthave no direct effects on its production. This action increases gastric pH, providingsymptomatic relief of hyperacidity. Magaldrate reacts with gastric acid in stages. Thehydroxymagnesium is relatively rapidly converted to magnesium ion and thealuminates to hydrated aluminium hydroxide; the magnesium ion rapidly neutralizesor buffers existing acid while the aluminium hydroxide reacts more slowly to give asustained antacid effect.Usual Dosage5 mL to 10 mL (or equivalent dose if tablets are available) taken 3 to 4 times a day,administered between meals and at bedtime, or as directed by the doctor.Use in children - Not recommended in children under 6 years of age unless, directed by

the doctor.Patient InformationDo not exceed the recommended dosage of suspension 40 mL in a 24 hour period. Do not usemaximum dosage of this product for more than 2 weeks, except under the advice andsupervision of a doctor. Suspension may be followed by a sip of water, if desired. Chewabletablets should be chewed before swallowing.LOMUS Drug Information CenterLomus Pharmaceuticals Pvt. Ltd.P.O. Box No 4506, Lomus House (Corporate office),Kailash Chour, Lazimpat, Kathmandu, NepalPh: 4436396 (Hunting Line). Fx: 977-1-4436395E-mail: druginfo@lomus.com.np