2006 The top 800 UK & 1250 Global companies by R&D investment

Ranking of the top 1250 global companies by R&D investment within industry sectors–––––––––––––––––– 2005/06 R&D investment –––––––––––––––––– ——–—–– Operating profit ——–—–– ––––––––––––––––– Sales and employees ––––––––––––––––– ————––—–––—— R&D and employees ——–—––——––––—–––––––––– Sales –––––––––– ––––– Sales / employee ––––– ––––––––– Employees ––––––––– ––––– R&D / employee ––––– Sales––––– Growth ––––– operating R&D + ––––– Growth ––––– ––––– Growth ––––– –––––– Growth ––––– ––––– Growth ––––– –––––– Growth ––––– outside –––Market cap –––change change profit sales capex as change change sales change change change change change change change change region changeCompany £m 1 yr % 4 yr % % % % sales £m 1 yr % 4 yr % % £m 1 yr % 4 yr % £000 1 yr % 4 yr % number 1 yr % 4 yr % £000 1 yr % 4 yr % % £m %33 Pharmaceuticals & biotechnology continuedTanox, USA 27.90 76 107 n/m 107.2 128.7 -14 n/m n/m -54.1 26 118 347 143.0 52 201 182 43 50 153.3 23 38 n/a 362 n/aKrka, Slovenia 27.57 15 37 34.1 7.2 21.7 81 61 95 21.3 381 17 40 72.9 5 13 5224 12 24 5.3 3 10 0 1683 92Flamel Technologies, France 27.55 34 141 n/m 200.5 248.4 -21 -513 >-999 -156.3 14 -57 -16 53.1 -63 -40 259 16 51 106.4 16 69 n/a 233 10Antigenics, USA 27.42 15 40 n/m >999.9 >999.9 -43 n/m n/m >-999.9 0 -11 -81 2.1 42 -76 171 -37 -25 160.4 83 89 n/a 47 n/aGen-Probe, USA 26.80 11 -14 50.2 15.0 29.9 53 12 132 30.0 178 13 61 205.8 6 24 866 7 18 30.9 4 -34 n/a 1602 n/aAriad Pharmaceuticals, USA 26.75 66 123 n/m >999.9 >999.9 -33 n/m n/m >-999.9 1 64 231 6.6 9 85 108 50 76 247.6 10 26 n/a 144 n/aTsumura, Japan 26.51 -1 9 52.3 6.3 10.0 51 -2 >999 12.1 419 3 9 151.5 n/a n/a 2763 n/a n/a 9.6 n/a n/a n/a 1111 36Vernalis, UK 26.49 24 9 n/m 187.5 192.6 -33 n/m n/m -232.3 14 -7 46 96.8 -17 n/a 146 11 n/a 181.4 11 n/a 59 211 56SkyePharma, UK 26.00 -7 31 n/m 42.4 47.6 -39 n/m n/m -63.0 61 -1 6 134.1 -5 6 457 4 1 56.9 -11 30 22 181 -51Biomarin Pharmaceutical, USA 25.49 -12 n/a n/m 170.5 182.0 -37 n/m n/a -250.2 15 38 n/a 47.6 57 n/a 314 -13 n/a 81.2 1 n/a n/a 778 126Suzuken, Japan 25.44 12 18 22.9 0.4 1.0 111 -21 8 1.7 6569 11 29 632.5 1 0 10385 10 29 2.5 2 -9 n/a 2119 47Parexel International, USA 25.28 15 n/a n/m 6.5 11.2 -1 -105 -107 -0.2 391 2 34 76.1 -3 28 5140 5 5 4.9 9 n/a n/a 457 n/aAlkermes, USA 25.15 -34 -27 334.5 25.9 43.1 8 n/a n/a 7.7 97 119 208 127.7 52 101 760 44 54 33.1 -54 -53 n/a 914 10Pharmion, USA 25.01 51 n/a 936.2 19.4 21.8 3 n/a n/a 2.1 129 70 452 392.9 50 n/a 328 13 n/a 76.3 33 n/a n/a 308 n/aSartorius, Germany 24.58 21 33 88.7 7.4 9.3 28 33 122 8.3 333 4 6 91.8 6 9 3623 -2 -3 6.8 24 37 42 393 40Stada Arzneimittel, Germany 23.69 32 24 27.1 3.4 4.8 87 53 72 12.5 702 26 50 180.4 -17 -13 3892 51 73 6.1 -12 -32 6 1369 27Neurochem, Canada 22.99 57 164 n/m >999.9 >999.9 -37 n/m n/m >-999.9 2 >999 455 11.5 >999 n/a 192 16 n/a 119.7 35 n/a n/a 244 n/aQiagen, The Netherlands 22.78 14 34 41.4 9.8 13.3 55 14 52 23.7 232 5 23 146.0 -13 16 1589 20 4 14.3 -5 27 n/a 1306 21ProStrakan, UK 22.43 119 187 n/m 70.9 75.5 -37 n/m n/m -117.0 32 47 233 106.9 -22 31 296 87 191 75.8 17 -5 0 197 n/aPerrigo, USA 22.38 39 74 n/m 3.8 6.4 -193 -403 -497 -32.3 597 14 24 102.0 -47 -38 5848 116 97 3.8 -36 -14 n/a 879 n/aBerna Biotech, Switzerland 22.23 -4 5 n/m 29.5 37.3 -7 n/m -253 -9.0 75 -17 -29 105.2 3 -20 715 -19 -15 31.1 19 34 n/a 187 4Zambon, Italy 21.30 -3 n/a 113.0 7.2 12.6 19 -38 n/a 6.3 298 -6 n/a 126.6 -3 n/a 2352 -3 n/a 9.1 -1 n/a 13 n/l n/lNyco, Denmark 21.12 20 n/a n/m 6.1 9.4 -25 -170 n/a -7.2 349 -21 n/a 107.3 -27 n/a 3252 8 n/a 6.5 11 n/a n/a n/l n/lUnited Therapeutics, USA 21.00 18 15 85.4 31.1 36.4 25 238 n/a 36.4 68 58 185 321.5 28 118 210 24 38 100.0 -5 -18 n/a 741 n/aGeron, USA 20.43 17 21 n/m 569.6 596.3 -22 n/m n/m -612.5 4 485 247 39.9 329 255 90 36 2 227.0 -14 5 n/a 231 n/aNeurogen, USA 20.13 56 23 n/m 457.3 481.9 -24 n/m n/m -536.7 4 -61 -43 25.2 -62 n/a 175 3 n/a 115.0 51 n/a n/a 104 n/aSalix Pharmaceuticals, USA 20.12 70 123 n/m 22.3 23.9 -36 >-999 n/m -39.4 90 47 185 419.7 2 51 215 43 65 93.6 18 34 n/a 281 n/aXoma, Bermuda 20.01 -32 -13 n/m 184.1 210.0 -21 n/m n/m -191.7 11 409 -1 49.9 414 -1 218 -1 0 91.8 -31 -13 n/a 101 2634 Real estate n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/aNo companies with sufficient R&D for inclusion n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a35 Software & computer services 16370.69 9.3 16.9 53.3 10.4 14.3 30719 16.2 116.3 19.6 157072 6.8 16.5 165.5 -0.6 6.4 930079 6.4 10.9 17.5 2.4 6.8 n/a 523459 n/aMicrosoft, USA 3835.04 6 15 40.0 14.9 18.4 9595 13 44 37.2 25793 11 29 360.5 -5 1 71553 17 28 53.6 -9 -10 n/a 144035 -15IBM, USA 3132.57 4 12 41.7 5.9 10.1 7520 1 20 14.2 53084 -5 3 161.2 -5 1 329373 0 3 9.5 4 10 62 67661 -11Oracle, USA 1090.40 26 49 39.5 13.0 14.7 2764 19 31 33.0 8376 22 40 149.2 8 9 56133 13 29 19.4 12 16 n/a 45066 13SAP, Germany 748.00 7 14 46.5 12.8 15.6 1607 17 60 27.5 5849 13 16 169.3 2 -1 34550 11 18 21.7 -4 -3 n/a 31037 -1CA, USA 454.92 3 8 482.1 20.5 24.3 94 41 n/a 4.3 2216 8 18 138.5 3 16 16000 5 1 28.4 -2 6 n/a 7244 -21Symantec, USA 397.32 104 188 249.0 16.5 22.9 160 -67 -36 6.6 2413 60 139 150.8 -35 -23 16000 146 220 24.8 -17 -9 51 10370 -32Google, USA 349.20 52 170 29.7 9.8 23.4 1177 218 420 32.9 3576 92 261 629.5 2 n/a 5680 88 n/a 61.5 -19 n/a 39 66292 41Yahoo!, USA 342.22 52 168 26.6 11.2 19.0 1287 81 479 42.0 3062 47 206 312.5 14 69 9800 29 99 34.9 18 38 n/a 22091 -22Cadence Design Systems, USA 246.59 9 18 414.7 31.8 37.2 59 10 -10 7.7 774 11 5 154.8 9 8 5000 2 -2 49.3 6 20 52 2631 4Unisys, USA 226.93 -6 -9 n/m 6.8 8.7 -62 n/m -150 -1.8 3354 -1 -1 92.9 0 2 36100 -1 -3 6.3 -5 -6 n/a 1011 -20Adobe Systems, USA 212.80 17 38 50.2 18.6 21.1 424 23 90 37.0 1145 18 47 199.7 -35 -17 5734 82 76 37.1 -36 -22 n/a 10974 43Sega Sammy, Japan 205.25 n/a n/a 46.1 8.1 12.8 445 n/a n/a 17.5 2545 n/a n/a 470.7 n/a n/a 5407 n/a n/a 38.0 n/a n/a n/a 5610 n/aIntuit, USA 196.06 -3 30 63.5 16.5 18.4 309 26 128 26.0 1187 9 33 169.6 4 24 7000 4 8 28.0 -7 21 n/a 6106 24Synopsys, USA 186.39 11 29 n/m 32.3 36.7 -9 -118 -185 -1.6 578 -9 3 121.5 -16 -12 4756 9 17 39.2 2 10 n/a 1504 4Dassault Systemes, France 177.93 17 19 112.8 27.7 30.3 158 0 14 24.6 642 17 22 112.8 -8 -13 5693 28 39 31.3 -9 -15 53 3161 1Autodesk, USA 175.68 26 53 81.4 19.8 21.1 216 55 210 24.3 887 23 54 184.3 -11 13 4813 38 36 36.5 -9 12 n/a 4554 -7Cerner, USA 159.59 19 63 194.2 23.6 32.3 82 24 159 12.2 676 25 53 99.0 -2 10 6830 28 41 23.4 -7 17 n/a 1899 11BMC Software, USA 156.86 -5 -45 209.6 18.0 19.6 75 454 n/a 8.6 873 2 9 140.8 14 17 6200 -10 -7 25.3 6 -41 n/a 2826 9SunGard Data Systems, USA † 142.59 -4 21 56.7 6.3 11.6 252 -45 -26 11.0 2280 13 45 152.0 -2 -2 15000 15 48 9.5 -16 -18 24 n/l n/lMentor Graphics, USA 123.88 5 23 >999.9 30.2 33.8 12 -48 18 2.9 411 -1 9 102.7 -4 -4 4000 4 14 31.0 1 9 n/a 655 77Novell, USA 116.86 1 8 46.9 16.8 19.3 249 762 n/a 35.7 698 3 8 137.7 25 34 5066 -18 -20 23.1 23 35 n/a 1236 -6BEA Systems, USA 106.16 24 35 87.0 15.2 16.9 122 6 80 17.5 699 11 20 180.2 -4 -2 3878 16 23 27.4 8 10 n/a 2523 19McAfee, USA 102.72 2 8 111.6 17.9 20.8 92 -72 -5 16.0 575 8 6 174.8 -3 13 3290 12 -7 31.2 -8 14 41 1931 -31Nintendo, Japan 101.24 30 27 18.6 4.0 4.4 543 -2 -4 21.4 2542 0 1 n/a n/a n/a n/a n/a n/a n/a n/a n/a 73 15574 75Sybase, USA 100.72 11 13 141.8 21.1 23.1 71 34 589 14.9 477 4 -1 128.4 0 4 3715 4 -6 27.1 6 19 n/a 1114 0Business Objects, France 94.68 8 73 123.1 15.1 18.9 77 55 108 12.3 627 16 83 142.0 1 25 4418 15 45 21.4 -6 20 n/a 1218 -34Compuware, USA 92.51 -8 3 102.0 13.2 14.4 91 47 >999 12.9 702 -2 -14 93.5 3 4 7510 -5 -17 12.3 -3 21 34 1510 -19Misys, UK 89.70 -1 1 164.9 9.1 9.8 54 44 16 5.5 985 11 3 152.5 12 4 6456 -1 -1 13.9 0 3 44 1320 13Amdocs, UK 84.14 14 22 42.7 7.1 10.6 197 14 84 16.6 1187 15 27 91.3 -6 -2 13000 23 30 6.5 -7 -7 76 4178 19Sage, UK 81.61 10 36 38.7 10.5 12.5 211 14 39 27.2 777 13 36 89.4 -1 -5 8686 14 43 9.4 -4 -5 49 2965 -2114 The 2006 R&D ScoreboardThe 2006 R&D Scoreboard 115