2006 The top 800 UK & 1250 Global companies by R&D investment

Ranking of the top 1250 global companies by R&D investment within industry sectors–––––––––––––––––– 2005/06 R&D investment –––––––––––––––––– ——–—–– Operating profit ——–—–– ––––––––––––––––– Sales and employees ––––––––––––––––– ————––—–––—— R&D and employees ——–—––——––––—–––––––––– Sales –––––––––– ––––– Sales / employee ––––– ––––––––– Employees ––––––––– ––––– R&D / employee ––––– Sales––––– Growth ––––– operating R&D + ––––– Growth ––––– ––––– Growth ––––– –––––– Growth ––––– ––––– Growth ––––– –––––– Growth ––––– outside –––Market cap –––change change profit sales capex as change change sales change change change change change change change change region changeCompany £m 1 yr % 4 yr % % % % sales £m 1 yr % 4 yr % % £m 1 yr % 4 yr % £000 1 yr % 4 yr % number 1 yr % 4 yr % £000 1 yr % 4 yr % % £m %33 Pharmaceuticals & biotechnology continuedTheravance, USA 73.54 53 76 n/m >999.9 >999.9 -87 n/m n/m >-999.9 7 35 185 26.0 23 n/a 270 10 n/a 272.4 39 n/a n/a 832 31OSI Pharmaceuticals, USA 73.37 14 51 n/m 72.3 87.6 -96 n/m n/m -94.9 101 307 466 154.9 181 279 655 45 50 112.0 -21 3 n/a 1137 -3Novozymes, Denmark 73.05 -2 8 66.2 12.6 18.3 110 12 20 19.1 579 4 10 143.8 2 1 4023 2 9 18.2 -4 -2 56 2673 n/aWatson Pharmaceuticals, USA 72.96 -2 34 58.4 7.6 12.4 125 -14 -20 13.0 959 0 20 249.4 1 17 3844 0 3 19.0 -2 32 n/a 1466 -31Kos Pharmaceuticals, USA 71.78 11 107 68.2 16.4 18.2 105 55 317 24.1 438 51 185 321.7 17 86 1361 29 66 52.7 -14 31 n/a 1144 -41Pliva, Croatia 70.40 -7 23 615.4 10.4 14.2 11 -87 -91 1.7 675 3 14 110.1 11 30 6137 -8 -13 11.5 1 40 42 1550 n/aAbgenix, USA (now part of Amgen) 69.12 11 31 n/m 646.9 684.1 -120 n/m n/m >-999.9 11 3 -17 24.3 23 -28 440 -16 8 157.1 32 22 n/a n/l n/lValeant Pharmaceuticals, USA 66.26 23 109 n/m 13.7 19.2 -63 n/m n/m -13.0 484 22 12 128.6 39 97 3767 -13 -53 17.6 41 214 n/a 1001 -6CV Therapeutics, USA 63.78 5 31 n/m 577.8 625.1 -131 n/m n/m >-999.9 11 -7 73 17.6 -61 -32 627 137 163 101.7 -55 -51 n/a 302 -55Ranbaxy Laboratories, India 63.74 21 123 295.8 9.2 26.4 22 -80 -77 3.1 691 -3 24 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 1854 -31Vertex Pharmaceuticals, USA 63.05 1 -1 n/m 67.3 77.8 -115 n/m n/m -123.1 94 57 29 115.3 42 39 813 10 -5 77.6 -8 0 n/a 2071 119Kyorin Pharmaceutical (now Kyorin), Japan 62.67 54 n/a 382.9 19.2 27.9 16 -68 n/a 5.0 327 2 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 12 531 n/aSanten Pharmaceutical, Japan 62.28 6 7 70.0 13.6 18.9 89 36 40 19.4 457 3 4 198.2 4 6 2308 -1 -2 27.0 8 10 7 1215 0CSL, Australia 62.27 44 59 37.5 5.3 9.1 166 42 115 14.1 1175 61 112 181.5 99 n/a 6474 -19 n/a 9.6 78 n/a n/a 4128 n/aNPS Pharmaceuticals, USA 60.94 -19 14 n/m 815.8 919.9 -90 n/m n/m >-999.9 7 -10 40 21.0 -10 -9 355 0 48 171.7 -19 -23 n/a 100 -56Regeneron Pharmaceuticals, USA 60.07 n/m 46 n/m 155.8 163.3 -55 -294 n/m -141.7 39 -62 -4 65.6 -53 14 588 -19 -11 102.2 n/m 59 n/a 446 n/aMylan Laboratories, USA 59.45 16 22 33.4 8.1 16.4 178 -2 -26 24.3 732 0 1 252.5 4 -10 2900 -3 11 20.5 20 10 n/a 2826 24Invitrogen, USA 57.84 36 99 73.3 8.3 14.3 79 0 270 11.3 698 17 56 145.4 -7 0 4800 26 57 12.1 8 30 n/a 1757 -34Neurocrine Biosciences, USA 56.76 11 21 n/m 78.7 84.5 -15 n/m n/m -20.2 72 46 75 122.7 -4 -5 588 53 93 96.5 -27 -38 n/a 196 n/aIncyte, USA 55.70 8 -33 n/m >999.9 >999.9 -58 n/m n/m >-999.9 5 -45 -92 25.8 -42 -77 177 -5 -59 314.7 14 54 n/a 213 -39Cell Genesys, USA 53.82 0 22 n/m >999.9 >999.9 -62 n/m n/m >-999.9 3 -60 -81 10.0 -44 -78 267 -29 -19 201.6 42 53 n/a 122 -21Alexion Pharmaceuticals, USA 52.61 64 75 n/m >999.9 >999.9 -64 n/m n/m >-999.9 0 -87 -90 1.5 -88 -93 222 9 26 237.0 50 42 n/a 629 42Endo Pharmaceuticals, USA 51.44 75 79 28.2 10.8 12.0 182 35 232 38.2 478 33 76 672.9 3 -12 710 29 91 72.4 35 -22 n/a 2555 19Idenix Pharmaceuticals, USA 50.26 8 62 n/m 133.3 143.5 -33 n/m n/m -86.3 38 -32 51 172.9 -61 n/a 218 74 n/a 230.6 -38 n/a n/a 292 n/aKissei Pharmaceutical, Japan 48.82 1 -17 133.0 16.2 19.0 37 -22 -3 12.2 301 5 3 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 591 -8InterMune, USA 48.19 2 -14 n/m 56.3 57.8 -24 n/m n/m -27.8 86 -3 29 443.3 64 80 193 -41 -26 249.7 72 16 n/a 302 6Amylin Pharmaceuticals, USA 45.65 -8 12 n/m 55.8 76.9 -122 n/m n/m -149.0 82 310 321 71.2 114 91 1150 92 171 39.7 -52 -62 n/a 3425 183King Pharmaceuticals, USA 43.11 9 68 42.6 4.2 7.2 101 n/a 20 9.8 1034 36 49 369.9 34 38 2795 1 8 15.4 8 59 n/a 2411 25Biovitrum, Sweden 42.16 8 37 n/m 61.5 76.5 -8 n/m >-999 -12.3 69 19 -14 113.5 14 -16 604 4 2 69.8 3 32 n/a n/l n/lImClone Systems, USA 41.88 24 -22 107.7 18.7 40.7 39 -47 n/a 17.4 223 -1 173 225.5 -14 96 991 14 69 42.3 8 -59 n/a 1648 7Nippon Shinyaku, Japan 41.85 3 14 104.0 15.6 20.0 40 146 80 15.0 268 6 5 147.8 n/a n/a 1811 n/a n/a 23.1 n/a n/a n/a 359 8MGI PHARMA, USA 41.29 13 57 n/m 25.4 26.3 -78 n/m n/m -47.8 163 43 265 283.0 -30 51 575 104 175 71.8 -44 -43 n/a 656 -40Nektar Therapeutics, USA 40.81 58 13 n/m 55.5 69.7 -107 n/m n/m -145.6 74 11 29 94.7 -6 12 777 17 15 52.5 35 -2 n/a 578 -1Chr Hansen (now ALK-Abello), Denmark 40.72 -2 3 135.2 10.1 18.2 30 2 21 7.5 404 -2 -3 109.4 -3 -7 3688 1 4 11.0 -4 0 n/a 708 -16Genmab, Denmark 40.69 18 35 n/m 448.4 456.7 -39 n/m n/m -434.4 9 >999 444 42.6 >999 409 213 3 35 191.0 14 -7 n/a 795 188Cell Therapeutics, USA 40.06 -32 -6 n/m 427.3 439.9 -79 n/m n/m -841.3 9 -46 -17 43.8 2 33 214 -47 -34 187.2 28 45 29 76 -24Cambridge Antibody, UK(now part of AstraZeneca) 39.17 -11 10 n/m 20.2 21.2 -9 n/m n/m -4.8 194 >999 >999 683.0 >999 >999 284 0 5 137.9 -12 7 99 n/l n/lNabi Biopharmaceuticals, USA 38.93 10 112 n/m 61.9 69.9 -76 n/m n/m -120.6 63 -40 -45 81.1 -44 -52 776 7 12 50.2 3 93 15 180 -63Medicis Pharmaceutical, USA 38.26 298 203 66.8 17.4 18.2 57 -6 32 26.1 220 24 62 611.5 10 23 359 13 31 106.6 254 117 n/a 615 n/aICOS, USA 37.92 17 1 n/m 91.2 98.1 -43 n/m n/m -104.0 42 -4 -13 59.4 -8 -30 700 4 19 54.2 13 -17 n/a 896 0Medicines, USA 37.51 31 65 n/m 42.9 45.1 -7 -177 n/m -8.0 87 4 113 318.2 -17 50 275 25 55 136.4 5 6 n/a 615 -3Encysive Pharmaceuticals, USA 36.99 12 132 n/m 453.4 468.2 -45 n/m n/m -555.4 8 2 25 37.1 -46 -40 220 88 108 168.1 -40 13 n/a 146 -64Par Pharmaceutical Companies, USA 36.67 25 142 466.0 14.5 22.6 8 -70 -88 3.1 252 -37 -14 329.5 -46 -41 766 17 50 47.9 7 72 n/a 316 n/aVasogen, Canada 35.61 38 199 n/m n/a n/a -48 n/m n/m n/a 0 n/m n/m 0.0 n/m n/m 172 n/a n/a 207.1 n/a n/a n/a 20 n/aBiovail, Canada 35.23 21 35 20.1 6.5 10.5 175 45 134 32.1 545 6 21 312.5 39 31 1744 -24 -7 20.2 59 46 88 1493 -11CuraGen, USA 35.13 -9 5 n/m 256.3 296.3 -45 n/m n/m -326.2 14 271 71 20.6 153 37 666 47 24 52.7 -38 -25 n/a 102 -29Acambis, UK 34.50 19 67 n/m 84.4 97.1 -31 -238 -320 -74.8 41 -52 -52 148.7 -50 -52 275 -5 11 125.5 25 44 96 142 -49Gedeon Richter, Hungary 34.35 19 45 31.2 7.4 25.7 110 8 42 23.5 467 15 32 57.8 n/a n/a 8084 n/a n/a 4.2 n/a n/a 19 2210 30Nuvelo, USA 33.65 45 36 n/m >999.9 >999.9 -42 n/m n/m >-999.9 0 178 -96 3.1 116 -95 103 29 -11 326.7 12 29 35 489 n/adeCODE genetics, Iceland 33.33 22 -15 n/m 156.0 166.9 -40 n/m n/m -188.0 21 -13 -9 44.5 -22 -11 480 12 -2 69.4 9 -13 42 164 n/aSysmex, Japan 32.12 17 43 74.4 8.5 11.6 43 41 124 11.4 380 17 47 121.9 9 4 3115 7 40 10.3 9 0 n/a 1256 37Basilea Pharmaceuticals, Switzerland 32.00 5 23 n/m 237.4 241.3 -22 n/m n/m -166.7 13 >999 >999 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 602 78GPC Biotech, Germany 31.84 68 130 n/m 496.1 496.1 -45 n/m n/m -696.9 6 -26 -44 28.9 -43 -53 222 30 19 143.4 29 89 n/a 245 12QLT, Canada 31.57 39 56 n/m 26.2 29.4 -173 n/m n/m -143.7 121 30 69 275.5 41 47 438 -8 15 72.1 50 33 46 366 n/aZeltia, Spain 31.39 24 11 n/m 63.4 66.6 -28 n/m n/m -56.0 50 -9 4 83.7 -18 -7 592 11 12 53.0 12 0 0 877 7Isis Pharmaceuticals, USA 31.37 -37 -7 n/m 134.2 135.2 -33 n/m n/m -142.5 23 -6 -29 90.6 11 18 258 -15 -40 121.6 -26 40 n/a 281 50Kaken Pharmaceutical, Japan 30.95 -1 13 97.8 8.4 10.2 32 17 17 8.6 370 3 3 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 465 16Recordati, Italy 30.89 20 32 40.9 7.7 9.4 75 28 57 18.8 401 19 23 205.9 10 25 1946 8 -2 15.9 11 34 11 796 -9Dr Reddy's Laboratories, India 29.73 26 99 477.4 12.5 27.1 6 -76 -84 2.6 238 -5 17 39.6 n/a n/a 6000 n/a n/a 5.0 n/a n/a n/a 1373 n/aCubist Pharmaceuticals, USA 28.52 -12 -4 n/m 40.6 42.3 -15 n/m n/m -21.0 70 77 407 190.4 44 262 369 23 52 77.3 -29 -39 n/a 705 33Toyama Chemical, Japan 28.44 12 9 354.0 36.1 38.5 8 n/a n/a 10.2 79 -5 -43 82.4 -10 -13 958 5 -35 29.7 6 57 n/a 762 77Myriad Genetics, USA 28.05 29 96 n/m 58.4 66.6 -25 n/m n/m -51.9 48 45 50 73.1 13 13 657 29 33 42.7 0 46 n/a 580 n/a112 The 2006 R&D ScoreboardThe 2006 R&D Scoreboard 113