2006 The top 800 UK & 1250 Global companies by R&D investment

Ranking of the top 1250 global companies by R&D investment within industry sectors–––––––––––––––––– 2005/06 R&D investment –––––––––––––––––– ——–—–– Operating profit ——–—–– ––––––––––––––––– Sales and employees ––––––––––––––––– ————––—–––—— R&D and employees ——–—––——––––—–––––––––– Sales –––––––––– ––––– Sales / employee ––––– ––––––––– Employees ––––––––– ––––– R&D / employee ––––– Sales––––– Growth ––––– operating R&D + ––––– Growth ––––– ––––– Growth ––––– –––––– Growth ––––– ––––– Growth ––––– –––––– Growth ––––– outside –––Market cap –––change change profit sales capex as change change sales change change change change change change change change region changeCompany £m 1 yr % 4 yr % % % % sales £m 1 yr % 4 yr % % £m 1 yr % 4 yr % £000 1 yr % 4 yr % number 1 yr % 4 yr % £000 1 yr % 4 yr % % £m %33 Pharmaceuticals & biotechnology continuedAstraZeneca, UK 1968.20 -11 3 52.0 14.1 17.6 3787 36 54 27.1 13950 12 28 215.0 11 16 64900 1 11 30.3 -12 -6 n/a 50344 20Eli Lilly, USA 1762.29 12 28 107.6 20.7 29.5 1638 -6 -17 19.2 8531 6 19 200.2 10 23 42600 -4 -3 41.4 17 32 47 37285 7Wyeth, USA 1601.46 12 29 56.6 14.7 20.4 2828 n/a 82 25.9 10925 8 21 219.7 12 27 49732 -3 -5 32.2 15 36 n/a 38055 7Bristol-Myers Squibb, USA 1599.49 10 20 65.4 14.3 18.1 2447 -3 -2 21.9 11188 -1 0 260.2 -1 3 43000 0 -3 37.2 10 23 n/a 27248 -4Amgen, USA 1347.86 14 63 47.7 18.6 25.6 2824 45 170 39.0 7240 18 75 438.8 3 23 16500 15 46 81.7 0 14 17 48713 -16Schering-Plough, USA 1086.32 16 28 379.1 19.6 24.6 287 n/a -60 5.2 5538 15 4 169.9 8 -3 32600 7 8 33.3 9 19 62 17817 -5Abbott Laboratories, USA 1060.80 7 11 38.0 8.2 13.6 2793 10 33 21.5 13011 14 22 217.8 15 40 59735 -1 -13 17.8 9 27 n/a 41978 0Boehringer Ingelheim, Germany 934.45 10 15 70.7 14.3 19.8 1321 40 89 20.2 6551 17 28 175.1 10 10 37406 6 16 25.0 4 -1 67 n/l n/lTakeda Pharmaceutical, Japan 698.09 9 27 33.5 12.6 17.4 2084 -3 18 37.6 5542 3 10 381.9 4 12 14510 -1 -3 48.1 10 30 41 34373 27Schering, Germany (now part of Bayer) 679.54 6 7 106.1 18.6 22.6 640 30 47 17.6 3647 8 8 145.7 13 12 25037 -4 -4 27.1 11 11 n/a 12046 70Merck, Germany 489.90 19 21 89.6 12.1 16.7 547 24 32 13.6 4033 0 -16 139.4 0 -4 28927 0 -12 16.9 19 37 54 9342 266Novo Nordisk, Denmark 468.41 17 22 60.5 15.1 26.6 774 22 35 24.9 3110 16 29 147.1 7 6 21146 8 21 22.2 8 0 60 11332 20Biogen Idec, USA 435.50 10 175 353.0 30.9 44.0 123 722 n/a 8.7 1411 10 172 422.5 40 93 3340 -22 38 130.4 41 105 n/a 8534 4Sankyo, Japan(now part of Daiichi Sankyo) 427.14 0 4 133.4 14.7 19.4 320 -17 -16 11.0 2901 -1 4 187.2 -27 -23 15500 35 34 27.6 -26 -24 34 n/l n/lEisai, Japan 386.55 14 34 90.9 14.7 18.8 425 3 36 16.2 2630 7 21 317.1 -1 9 8295 8 11 46.6 5 21 51 8053 29Serono, Switzerland 354.09 -1 38 n/m 23.5 29.4 -74 -124 -131 -4.9 1506 5 43 317.2 9 41 4750 -3 2 74.5 2 36 n/a 4245 -8UCB, Belgium 351.11 42 99 148.5 20.2 23.7 236 -8 -20 13.6 1740 -22 -10 204.2 -22 7 8525 -1 -17 41.2 43 133 n/a 4492 -1ALTANA, Germany 319.47 4 23 69.5 14.2 18.8 460 9 27 20.5 2248 10 23 169.9 -11 -8 13229 24 34 24.1 -16 -8 49 4340 -1Yamanouchi Pharmaceutical(now Astellas Pharma), Japan 290.39 -16 -8 96.9 13.2 15.1 300 -38 -34 13.6 2206 -13 -9 n/a n/a n/a n/a n/a n/a n/a n/a n/a 29 12856 11Daiichi Pharmaceutical, Japan(now part of Daiichi Sankyo) 283.36 -3 14 92.0 17.5 20.8 308 34 31 19.0 1621 2 2 n/a n/a n/a n/a n/a n/a n/a n/a n/a 18 n/l n/lGenzyme, USA 281.04 27 56 78.2 17.6 24.7 359 162 >999 22.6 1593 24 69 199.1 9 25 8000 14 37 35.1 11 15 n/a 10553 0Mitsubishi Pharma, Japan(now part of Mitsubishi Chemical) 249.14 0 33 225.7 21.6 26.0 110 8 31 9.6 1156 -1 1 195.4 3 14 5917 -3 -16 42.1 3 54 n/a n/l n/lChiron, USA(now part of Novartis, Switzerland) 245.11 2 15 273.2 21.9 32.3 90 120 -25 8.0 1118 11 39 203.3 9 19 5500 2 19 44.6 0 -4 49 n/l n/lForest Laboratories, USA 239.07 40 82 50.1 14.7 16.7 478 -28 0 29.4 1627 -8 18 322.3 -7 7 5050 -2 12 47.3 42 65 n/a 8741 10Allergan, USA 227.75 13 38 67.9 16.9 20.2 336 7 143 24.8 1351 13 34 267.2 13 39 5055 0 -5 45.1 13 42 n/a 9676 34MedImmune, USA 224.02 18 116 n/m 30.9 38.3 -26 n/m n/m -3.6 725 9 37 327.1 -10 -10 2215 22 51 101.1 -3 49 n/a 3642 -9Teva Pharmaceutical Industries, Israel 214.88 9 79 28.1 7.0 12.9 765 127 123 25.0 3058 9 66 208.1 3 25 14698 7 36 14.6 2 37 84 15750 37Cephalon, USA 206.68 30 116 n/m 29.3 39.0 -129 >-999 -523 -18.2 706 19 94 243.8 -10 9 2895 33 86 71.4 -3 21 n/a 2319 73Applera, USA 192.65 -12 -6 229.2 17.9 23.0 84 23 220 7.8 1075 1 6 218.0 10 20 4930 -8 -12 39.1 -5 6 55 3416 43Millennium Pharmaceuticals, USA 185.64 20 25 n/m 57.1 59.3 -126 n/m n/m -38.8 325 25 51 284.8 61 121 1142 -23 -35 162.6 55 85 n/a 1880 4Schwarz Pharma, Germany 177.91 31 81 n/m 26.1 29.1 -11 n/m -114 -1.6 681 5 -5 166.0 -3 -14 4100 8 11 43.4 21 64 47 2309 52Shire, UK 167.26 49 46 n/m 18.0 22.5 -96 -245 n/m -10.3 932 23 33 445.7 12 12 2090 10 18 80.0 35 23 n/a 4226 34Kyowa Hakko Kogyo, Japan 162.25 14 11 150.5 9.3 11.8 108 -29 47 6.2 1744 -2 -2 300.7 1 10 5800 -3 -12 28.0 17 26 8 1848 2Gilead Sciences, USA 161.77 24 57 25.0 13.7 16.1 646 76 661 54.7 1182 53 180 621.8 33 112 1900 15 43 85.1 8 7 51 16451 46Lundbeck, Denmark 159.72 35 15 81.2 19.1 25.5 197 -16 -2 23.5 835 -7 -1 166.4 -4 -7 5022 -3 5 31.8 38 7 43 3245 -6Ono Pharmaceutical, Japan 151.19 -1 9 50.6 21.1 23.0 299 14 34 41.7 717 4 8 n/a n/a n/a n/a n/a n/a n/a n/a n/a 0 3531 2Shionogi, Japan 145.14 -1 -3 93.8 14.8 17.5 155 491 124 15.7 984 -1 -40 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 3825 44Tanabe Seiyaku, Japan 137.14 13 25 108.4 16.2 19.7 127 -7 34 14.9 849 -1 -7 187.9 n/a n/a 4517 n/a n/a 30.4 n/a n/a n/a 1983 28Elan, Ireland 136.18 26 -19 n/m 54.7 64.7 -282 n/m n/m -113.5 249 -8 -60 135.6 -8 -24 1835 0 -45 74.2 26 43 68 4401 120Human Genome Sciences, USA 122.09 -3 14 n/m >999.9 >999.9 -147 n/m n/m >-999.9 11 399 169 12.7 376 211 880 5 -13 138.7 -7 28 n/a 721 -29Taisho Pharmaceutical, Japan 114.60 -4 -22 42.4 8.3 10.8 270 -16 -5 19.6 1379 -2 1 258.3 0 -5 5339 -3 6 21.5 -1 -27 n/a 3636 1Pierre Fabre, France 106.02 6 12 204.5 10.5 14.1 52 31 25 5.1 1010 3 14 110.6 4 7 9136 0 6 11.6 7 5 n/a n/l n/lProtein Design Labs(now PDL Biopharma), USA 100.21 40 118 n/m 61.5 76.3 -96 n/m n/m -59.1 163 191 341 166.7 97 126 977 48 98 102.6 -5 12 10 1163 -28Ipsen, France 99.23 17 14 89.0 18.3 22.8 112 17 18 20.6 542 1 7 146.5 -2 4 3699 3 3 26.8 14 11 n/a 1651 n/aMerial, UK 88.30 7 13 58.6 7.7 13.2 151 5 12 13.1 1152 6 15 192.8 11 20 5974 -4 -4 14.8 12 18 63 n/l n/lCelgene, USA 87.08 6 64 195.0 27.8 34.5 45 79 n/a 14.3 313 42 139 331.3 15 61 944 23 57 92.2 -14 10 n/a 9296 103Dainippon Pharmaceutical(now Dainippon Sumitomo Pharmaceutical), Japan 86.09 10 23 205.9 10.0 12.1 42 -24 -36 4.9 858 2 4 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 2971 166Sepracor, USA 84.17 -10 -32 >999.9 17.6 19.3 1 n/a n/a 0.1 478 116 194 232.2 78 55 2059 21 86 40.9 -25 -68 0 3148 -6Dade Behring, USA 82.42 6 34 69.8 8.5 17.5 118 10 -69 12.2 966 6 21 153.3 1 n/a 6300 5 n/a 13.1 1 n/a 54 2063 8Exelixis, USA 82.21 2 23 n/m 185.8 204.7 -55 n/m n/m -123.7 44 44 60 80.4 35 60 550 6 0 149.5 -4 23 n/a 438 22Hospira, USA 80.87 16 n/a 41.4 5.6 16.1 195 -22 n/a 13.6 1431 -7 n/a 110.1 0 n/a 13000 -7 n/a 6.2 25 n/a n/a 3977 11Ivax, USA(now part of Teva Pharmaceutical Industries, Israel) 79.33 -4 32 51.2 6.0 9.4 155 -2 5 11.8 1317 23 59 n/a n/a n/a n/a n/a n/a n/a n/a n/a 48 n/l n/lMedarex, USA 79.13 11 60 n/m 264.0 282.1 -94 n/m n/m -312.1 30 312 95 65.0 289 54 461 6 16 171.6 5 42 n/a 677 4Actelion, Switzerland 75.78 26 94 112.6 25.8 29.6 67 60 660 23.0 293 41 173 285.3 16 76 1028 21 76 73.7 4 5 52 1644 13Barr Pharmaceuticals, USA 74.78 -24 32 40.1 12.3 17.5 186 67 46 30.5 610 -20 7 330.3 -35 -35 1847 23 65 40.5 -38 -18 n/a 3207 12110 The 2006 R&D ScoreboardThe 2006 R&D Scoreboard 111