2006 The top 800 UK & 1250 Global companies by R&D investment

Market breadth by industry for those of the top 800 UK companies wherecomparable data is available (see notes on pages 248 to 256)——––––––––––––— Market breadth ——––––––––––––—R&D Sales Europe N. America Rest of World TotalCompany £m £m % % % %Vectura 10.21 4 98 1 1 100Hikma Pharmaceuticals 9.62 153 8 50 42 100Microscience (now Microscience Investments) 9.60 0 100 0 0 100Oxford Biomedica 9.33 1 6 94 0 100Axis-Shield 8.97 58 69 22 10 101Genus 8.54 183 72 13 14 99Sanofi-Synthelabo ** 8.51 237 97 0 2 99BTG 8.10 50 12 85 3 100Servier ** 7.81 9 100 0 0 100Novo Nordisk ** 6.97 64 100 0 0 100Phytopharm 6.86 7 46 0 54 100Protherics 6.75 18 9 91 0 100Genzyme ** 6.56 101 80 19 1 100Daiichi Pharmaceuticals ** 5.70 6 0 100 0 100Allergy Therapeutics 5.62 21 92 7 2 101Evolutec 5.35 0 0 100 0 100CeNeS Pharmaceuticals 4.89 0 0 100 0 100Amarin 4.84 0 0 100 0 100Ardana 4.01 0 100 0 0 100Ferring Laboratories ** 3.82 48 100 0 0 100Forum Bioscience ** 3.35 120 97 0 0 97Pharmagene (now Asterand) 3.14 3 36 58 6 100Proteome Sciences 3.13 0 100 0 0 100Otsuka Pharmaceutical ** 3.10 64 100 0 0 100Phoqus 2.50 0 39 61 0 100ReNeuron Holdings * 2.40 0 100 0 0 100Merck ** 2.37 45 100 0 0 100BioFocus † 2.23 12 57 41 2 100Osmetech 2.13 6 20 46 34 100Sequenom-Gemini ** 1.95 0 17 83 0 100BioProgress 1.90 4 3 97 0 100Tepnel Life Sciences 1.74 14 54 30 15 99SR Pharma 1.66 1 77 6 17 100Provalis 1.60 10 88 10 2 100Dechra Pharmaceuticals 1.33 208 99 0 0 99Respironics Respiratory ** 1.29 2 6 94 0 100ALTANA Pharma ** 1.22 20 100 0 0 100UCB Pharma ** 1.09 46 74 26 0 100Cephalon ** 1.05 12 100 0 0 100Acacia Biopharma ** 0.96 19 98 0 0 98Micap 0.95 0 100 0 0 100Serono ** 0.93 39 100 0 0 100Stem Cell Sciences 0.84 1 1 0 99 100Eirx Therapeutics 0.82 0 100 0 0 100ReGen Therapeutics 0.75 0 100 0 0 100Drew Scientific(now part of Escalon Medical, USA) 0.73 9 16 59 24 99Cyprotex 0.72 3 71 28 1 100Sareum 0.70 0 86 14 0 100Medical Marketing International 0.59 0 100 0 0 100Sinclair Pharma 0.54 7 65 33 2 100Orchid Biosciences Europe(now Orchid Cellmark) ** 0.47 14 94 5 1 100Cytomyx 0.44 6 78 14 8 10034 Real estateNo companies with sufficient R&D for inclusion35 Software & computer servicesMisys 89.70 985 56 37 7 100Amdocs 84.14 1187 24 68 8 100Sage 81.61 777 51 41 9 101iSOFT 18.28 262 94 0 6 100RM 16.81 263 99 0 1 100Intec Telecom Systems 16.51 116 34 36 30 100Autonomy 12.77 56 38 58 4 100Market breadth by industry for those of the top 800 UK companies wherecomparable data is available (see notes on pages 248 to 256)——––––––––––––— Market breadth ——––––––––––––—R&D Sales Europe N. America Rest of World TotalCompany £m £m % % % %Northgate Information Solutions 12.76 206 98 1 1 100NSB 12.69 48 3 97 0 100Royalblue 10.53 74 54 32 14 100Anite 10.16 189 82 6 12 100SCI Entertainment † 10.13 21 40 47 13 100DICOM 9.89 180 79 18 4 101Fair Isaac ** † 9.42 55 35 58 8 101Empire Interactive 8.43 29 57 41 2 100SurfControl 7.55 57 29 61 10 100Cramer Systems 6.38 39 76 19 5 100Ubiquity Software 6.30 7 21 63 16 100Microgen 6.16 41 91 0 7 98Superscape 5.92 4 17 80 3 100Macro 4 5.17 33 66 32 1 99MessageLabs 5.15 75 93 11 2 106Clearswift Systems 4.41 24 66 17 17 100SDL 3.88 78 42 52 6 100StatPro 3.71 11 75 16 9 100Detica 3.65 102 94 6 0 100AIT (now Portrait Software) 3.61 14 72 24 5 101TTP 3.36 22 70 23 6 99Transitive 3.34 1 0 100 0 100Alphameric 2.88 73 100 0 0 100Comino (now part of Civica) 2.84 26 100 0 0 100nCipher 2.84 17 48 40 11 99Pilat Media Global 2.66 13 30 60 10 100Kewill Systems 2.46 27 35 65 0 100PlusNet 2.45 35 100 0 0 100XKO 2.42 28 100 0 0 100Workplace Systems International 2.26 8 90 5 5 100Flomerics 2.21 11 39 40 21 100Recognition Systems (now Protagona) ** 2.08 1 76 19 4 99Newchurch 2.07 6 100 0 0 100Tadpole Technology 1.98 9 67 19 14 100Ant 1.96 3 52 13 36 101ClinPhone 1.94 34 26 66 8 100DRS Data & Research Services 1.72 12 65 0 30 95Vebnet 1.66 3 100 0 0 100Gresham Computing 1.61 14 71 18 11 100IBS OPENSystems † 1.61 21 100 0 0 100OMG 1.61 14 19 58 23 100Clarity Commerce Solutions 1.60 16 88 11 1 100Electronic Data Processing 1.60 7 96 2 0 98ASITE 1.56 2 100 0 0 100VI 1.45 10 61 13 27 101EasyScreen (now Refco Screens) 1.38 2 97 3 0 100Corpora 1.36 2 88 12 0 100Empower Interactive 1.35 6 46 0 54 100Mediasurface 1.25 7 92 8 0 100System C Healthcare 1.19 18 100 0 0 100AppSense 1.17 9 78 14 7 99FFastFill 1.12 4 84 16 0 100IDOX 1.11 14 100 0 0 100Financial Objects 1.10 14 92 3 5 100Rolfe & Nolan 1.10 24 54 41 5 100Z Group 1.05 5 86 6 7 99Civica 1.04 106 85 3 12 100Prologic 1.03 10 100 0 0 100ServicePower Technologies 1.02 8 22 78 0 100Sopheon 1.01 5 42 58 0 100Manpower Software 0.96 6 83 16 0 99Business Control Solutions 0.90 8 100 0 0 100Focus Solutions 0.89 5 99 0 0 99Clinical Computing 0.88 2 24 76 0 100IQ-Ludorum 0.84 2 2 98 0 100Zoo Digital † 0.84 10 96 0 0 9654 The 2006 R&D ScoreboardThe 2006 R&D Scoreboard 55