2006 The top 800 UK & 1250 Global companies by R&D investment

Ranking of the top 800 UK companies by R&D investment within industry sectors–––––––––––––––––– 2005/06 R&D investment –––––––––––––––––– ——–—–– Operating profit ——–—–– ––––––––––––––––– Sales and employees ––––––––––––––––– ————––—–––—— R&D and employees ——–—––——––––—–––––––––– Sales –––––––––– ––––– Sales / employee ––––– ––––––––– Employees ––––––––– ––––– R&D / employee ––––– Sales––––– Growth ––––– operating R&D + ––––– Growth ––––– ––––– Growth ––––– –––––– Growth ––––– ––––– Growth ––––– –––––– Growth ––––– outside –––Market cap –––change change profit sales capex as change change sales change change change change change change change change region changeCompany £m 1 yr % 4 yr % % % % sales £m 1 yr % 4 yr % % £m 1 yr % 4 yr % £000 1 yr % 4 yr % number 1 yr % 4 yr % £000 1 yr % 4 yr % % £m %33 Pharmaceuticals & biotechnology continuedAstraZeneca 1968.20 -11 3 52.0 14.1 17.6 3787 36 54 27.1 13950 12 28 215.0 11 16 64900 1 11 30.3 -12 -6 n/a 50344 20Pfizer ** 350.48 -41 -31 n/m 35.8 47.0 -9 -102 -102 -0.9 979 -10 7 169.8 -14 -7 5768 4 17 60.8 -43 -40 n/a n/l n/lShire 167.26 49 46 n/m 18.0 22.5 -96 -245 n/m -10.3 932 23 33 445.7 12 12 2090 10 18 80.0 35 23 n/a 4226 34Eli Lilly ** 139.82 -5 18 69.1 7.0 10.2 202 -13 3 10.1 1999 11 28 438.3 4 13 4560 7 14 30.7 -11 5 n/a n/l n/lRoche ** 101.02 1 16 598.1 17.2 23.1 17 n/a n/a 2.9 589 5 20 367.1 13 44 1604 -7 -20 63.0 8 40 n/a n/l n/lMerck Sharp & Dohme ** 90.68 45 31 n/m 23.5 48.3 -14 -145 -177 -3.5 386 -17 4 195.7 -14 -2 1972 -4 7 46.0 52 22 22 n/l n/lMerial 88.30 7 13 58.6 7.7 13.2 151 5 12 13.1 1152 6 15 192.8 11 20 5974 -4 -4 14.8 12 18 63 n/l n/lNovartis Pharmaceuticals ** 58.57 4 7 n/m 20.0 24.3 -1 -108 -108 -0.5 293 -8 4 170.1 -9 1 1723 0 3 34.0 4 4 0 n/l n/lCambridge Antibody(now part of AstraZeneca) 39.17 -11 10 n/m 20.2 21.2 -9 n/m n/m -4.8 194 >999 >999 683.0 >999 >999 284 0 5 137.9 -12 7 99 n/l n/lJanssen-Cilag ** 34.59 -3 18 128.8 16.2 17.4 27 197 336 12.6 214 2 11 253.3 21 3 843 -15 5 41.0 15 18 0 n/l n/lAcambis 34.50 19 67 n/m 84.4 97.1 -31 -238 -320 -74.8 41 -52 -52 148.7 -50 -52 275 -5 11 125.5 25 44 96 142 -49American Home Products ** 33.89 -32 -25 48.7 4.5 6.2 70 74 22 9.2 757 11 12 382.5 14 5 1979 -2 6 17.1 -30 -29 n/a n/l n/lOrganon Laboratories ** 31.49 3 10 694.6 30.8 38.6 5 46 7 4.4 102 -5 3 191.3 1 12 535 -6 -9 58.9 10 21 0 n/l n/lBristol-Myers Squibb ** 29.11 19 32 83.5 7.1 11.0 35 13 -10 8.5 410 7 16 202.6 -2 31 2022 9 -6 14.4 9 48 n/a n/l n/lVernalis 26.49 24 9 n/m 187.5 192.6 -33 n/m n/m -232.3 14 -7 46 96.8 -17 n/a 146 11 n/a 181.4 11 n/a 59 211 56SkyePharma 26.00 -7 31 n/m 42.4 47.6 -39 n/m n/m -63.0 61 -1 6 134.1 -5 6 457 4 1 56.9 -11 30 22 181 -51ProStrakan 22.43 119 187 n/m 70.9 75.5 -37 n/m n/m -117.0 32 47 233 106.9 -22 31 296 87 191 75.8 17 -5 0 197 n/aAlizyme 15.75 151 79 n/m n/a n/a -19 n/m n/m n/a 0 -100 -100 0.0 -100 -100 19 6 19 829.1 138 49 n/a 180 9Warner Chilcott(now Chilcott)(now part of Warner Acquisition) 15.72 -6 31 320.9 5.2 7.1 5 -93 -88 1.6 305 21 69 317.9 32 132 958 -8 -31 16.4 3 78 94 n/l n/lOSI Pharmaceticals ** 15.64 -24 8 n/m 100.0 102.5 -5 -409 n/m -31.5 16 -24 8 120.3 -16 0 130 -10 16 120.3 -16 0 100 n/l n/lBoehringer Ingelheim ** 15.59 -37 -27 98.3 8.7 12.8 16 6 70 8.9 178 20 33 204.2 19 20 874 1 11 17.8 -37 -31 0 n/l n/lJohnson & Johnson ** 15.00 1 -11 22.6 1.6 3.9 66 40 15 7.2 923 11 7 195.1 11 8 4733 0 -1 3.2 1 -11 n/a n/l n/lGenerics UK ** 14.34 38 109 n/m 14.7 17.0 -26 n/m >-999 -26.4 97 -26 -10 218.0 -23 -10 447 -4 3 32.1 44 107 n/a n/l n/lXenova(now part of Celtic Pharma Development) 14.28 -5 3 n/m 312.8 321.7 -15 n/m n/m -324.8 5 -41 -16 49.1 -33 14 93 -11 -16 153.5 7 20 59 n/l n/lArk Therapeutics 13.94 52 132 n/m 594.0 626.8 -19 n/m n/m -794.8 2 >999 >999 19.2 974 >999 122 42 138 114.3 7 -8 0 123 -2Astex Therapeutics 12.59 11 67 n/m 312.3 318.0 -12 n/m n/m -290.9 4 33 114 44.3 50 114 91 -12 10 138.4 25 57 21 n/l n/lInnovata 10.37 -20 -9 n/m 66.0 78.0 -9 n/m n/m -58.4 16 99 70 134.2 95 159 117 2 -37 88.6 -21 29 21 111 -13GW Pharmaceuticals 10.28 -26 -7 n/m 330.4 334.2 -10 n/m n/m -317.7 3 n/m 149 30.8 n/m 191 101 -21 2 101.7 -7 -12 100 92 15Vectura 10.21 17 109 n/m 227.7 236.5 -9 n/m n/m -210.4 4 57 47 44.0 55 13 102 1 24 100.1 16 87 2 162 93Hikma Pharmaceuticals 9.62 71 n/a 24.1 6.3 16.3 40 9 n/a 26.1 153 23 n/a 83.6 -4 n/a 1827 28 n/a 5.3 33 n/a 92 569 n/aMicroscience(now Microscience Investments) 9.60 -6 36 n/m >999.9 >999.9 -11 n/m n/m >-999.9 0 -55 -90 0.6 -54 -94 70 -3 27 137.2 -4 14 0 n/l n/lOxford Biomedica 9.33 1 -5 n/m >999.9 >999.9 -11 n/m n/m >-999.9 1 64 131 11.9 47 134 69 11 -5 135.2 -9 0 94 119 -13Arakis 9.00 n/a n/a n/m n/a n/a -11 n/a n/a n/a 0 n/a n/a 0.0 n/a n/a 36 n/a n/a 249.9 n/a n/a n/a n/l n/lAxis-Shield 8.97 -11 -9 482.4 15.4 23.6 2 n/a n/a 3.2 58 11 21 127.6 7 16 456 4 5 19.7 -14 -13 31 167 4IVAX(now part of Teva Pharmaceutical Industries, Israel) ** 8.65 -25 -20 n/m 6.0 6.9 -8 n/m n/m -5.2 145 -13 14 249.0 1 42 583 -15 6 14.8 -13 0 n/a n/l n/lGenus 8.54 -5 -1 88.6 4.7 7.2 10 8 35 5.3 183 0 8 140.9 2 14 1301 -2 -6 6.6 -3 5 28 248 94Sanofi-Synthelabo ** 8.51 10 -2 27.2 3.6 12.8 31 70 212 13.2 237 6 23 169.6 -1 11 1400 7 11 6.1 3 -12 3 n/l n/lYamanouchi(now Astellas Pharma Europe) ** 8.33 -66 -80 19.7 2.8 2.8 42 40 198 14.0 302 18 34 5213.2 -35 -50 58 81 57 143.7 -81 -92 n/a n/l n/lBTG 8.10 -49 -49 n/m 16.1 16.1 -12 n/m n/m -23.5 50 31 34 528.4 141 155 95 -46 -49 85.3 -6 -3 88 187 -31Servier ** 7.81 27 39 n/m 89.9 119.7 0 -119 -110 -0.3 9 20 30 119.1 27 29 73 -5 0 107.0 34 38 0 n/l n/lRenovo 7.72 26 99 n/m n/a n/a -10 n/m n/m n/a 0 n/m n/m 0.0 n/m n/m 94 24 91 82.1 2 4 n/a n/l n/lRandox Laboratories 7.65 -23 -5 n/m 23.7 30.0 -4 n/m >-999 -11.6 32 5 31 58.4 -4 -4 554 9 37 13.8 -29 -30 n/a n/l n/lNovo Nordisk ** 6.97 15 22 100.7 10.9 11.1 7 66 58 10.8 64 28 30 243.1 31 27 264 -3 2 26.4 18 27 0 n/l n/lPhytopharm 6.86 8 16 n/m 92.9 93.8 -3 n/m n/m -44.6 7 588 284 184.5 588 231 40 0 14 171.4 8 2 54 28 -32Protherics 6.75 47 152 n/m 38.1 52.9 -10 n/m n/m -53.7 18 -6 20 89.9 1 18 197 -7 5 34.2 59 155 91 203 57Genzyme ** 6.56 46 166 87.4 6.5 16.0 8 -15 59 7.5 101 18 48 198.0 2 8 508 15 36 12.9 26 104 20 n/l n/lDaiichi Pharmaceuticals ** 5.70 51 44 n/m 100.0 101.3 -2 -431 -432 -36.7 6 -25 -6 219.1 -23 2 26 -4 -7 219.1 57 56 100 n/l n/lAllergy Therapeutics 5.62 >999 243 n/m 27.3 31.7 -2 -255 -463 -11.7 21 14 27 90.0 22 34 229 -7 -5 24.5 >999 263 8 88 17Intercytex 5.61 32 78 n/m n/a n/a -7 n/m n/m n/a 0 n/m -100 0.0 n/m -100 56 17 48 100.1 13 20 n/a 49 n/aNapp Pharmaceutical 5.49 2 -53 32.5 4.5 11.5 17 39 95 13.7 123 18 30 173.0 10 21 713 8 8 7.7 -5 -56 n/a n/l n/lEvolutec 5.35 708 518 n/m >999.9 >999.9 -7 n/m n/m >-999.9 0 -26 -92 1.3 -60 -95 11 83 91 486.0 340 217 100 28 22NeuTec Pharma 5.14 56 124 n/m n/a n/a -5 n/m n/m n/a 0 n/m n/m 0.0 n/m n/m 20 33 51 256.9 17 54 n/a n/l n/lCeNeS Pharmaceuticals 4.89 41 6 n/m >999.9 >999.9 -8 n/m n/m >-999.9 0 2 -98 3.4 -11 -96 16 14 -67 305.8 23 85 100 20 -39Amarin 4.84 139 59 n/m >999.9 >999.9 -11 -240 n/m >-999.9 0 -51 -99 12.7 -62 -95 23 28 -69 210.6 87 280 100 264 >999Plethora Solutions 4.55 152 n/a n/m >999.9 >999.9 -6 n/m n/a >-999.9 0 n/m n/a 1.2 n/m n/a 14 180 n/a 325.1 -10 n/a n/a 43 79Lorantis 4.53 17 57 n/m n/a n/a -7 n/m n/m n/a 0 -100 -100 0.0 -100 -100 49 2 46 92.5 15 7 n/a n/l n/l- see notes on page 25422 The 2006 R&D ScoreboardThe 2006 R&D Scoreboard 23