Estrogen Receptor Null Mice - Endocrine Reviews
Estrogen Receptor Null Mice - Endocrine Reviews
Estrogen Receptor Null Mice - Endocrine Reviews
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406 COUSE AND KORACH Vol. 20, No. 3<br />
fore, the �ERKO mice have played a significant role in confirming<br />
many of the roles thought to be fulfilled by estrogen,<br />
whereas the �ERKO mice have and will continue to provide<br />
primary insight into the functions of the ER�. The generation<br />
of both models, as well as a forthcoming description of the<br />
��ERKO, will prove invaluable in elucidating the precise<br />
roles fulfilled by each ER, as well as any possible cooperative<br />
roles the two receptors might play within the same tissue or<br />
even within the same cell.<br />
Acknowledgments<br />
The authors are grateful to several individuals for their dedication,<br />
effort, and insight that has made the work described above possible: first<br />
and foremost, our original collaborators in the generation of the ERKO<br />
mice, Dr. Oliver Smithies for his efforts leading to the generation of both<br />
ERKO models; Dr. Dennis Lubahn for the �ERKO; and Drs. John Krege,<br />
Jeff Hodges, and Jan-Åke Gustafsson and laboratory for the �ERKO. The<br />
authors are exceptionally indebted to Sylvia Curtis, Todd Washburn, Dr.<br />
Jonathan Lindzey, Dr. Wayne Bocchinfuso, Mariana Yates, Linwood<br />
Koonce, James Clarke, Page Myers, Dr. Motohiko Taki, and Dr. Sean<br />
Kimbro for their efforts and dedication. We would also like to thank our<br />
several collaborators, Drs. Ralph Cooper, Richard DiAugustine, E. Mitch<br />
Eddy, Thomas Golding, Paul Kincaide, Diane Klotz, Michael Mendolsohn,<br />
Robert Moss, Jeffrey Moyer, Sonoko Ogawa, Donald Pfaff, Gabor<br />
Rubanyi, David Schomberg, Allen Silverstone, and Harold Varmus. We<br />
would also like to acknowledge Drs. Paul Shughrue and Istvan Merchenthaler<br />
for the contribution of Fig. 8.<br />
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