Terry Fox Laboratory - BC Cancer Agency
Terry Fox Laboratory - BC Cancer Agency Terry Fox Laboratory - BC Cancer Agency
British Columbia Cancer AgencyTERRY FOX LABORATORYSelect Current ContributionsNameAllen EavesRyan BrinkmanConnie EavesDonna HoggePamela HoodlessKeith HumphriesXiaoyan JiangRobert KayGerald KrystalPeter LansdorpDixie MagerClayton SmithFumio TakeiMembership/Committee InvolvementDirector, Stem Cell ServiceChair, MITACS Board of DirectorsMember, Board of Directors of the Stem Cell NetworkMember, Int’l Society for Analytical Cytometry Data Standards Task ForceMember, MSFHR Junior Graduate Scholarship Review CommitteeChairman & Supervisor, Management Committee of Joint Animal Facility, BCCAChair, NCIC Hematopoiesis & Growth Factors Review PanelAssociate Scientific Director, Stem Cell Network of CanadaMember, Board of Genome CanadaMember, 2005 Amer Assoc for Cancer Research Program CommitteeMember Int Society of Experimental Hematology Awards CommitteeDirector, Cryogenic Laboratory, Stem Cell ServiceChair, MSFHR Senior Graduate Trainee Awards CommitteeChair, MSFHR Post Doctoral Fellowship Trainee Awards CommitteeAlberta Cancer Board Research Initiative Program Grant CompetitionChair, Canadian Council of American Society for Gene TherapyDirector, Transgenic and Gene Targeting Facility, BCCAAssociate Editor, Experimental HematologyMember, Leukemia Research Fund of Canada Scientific Review PanelMember, External Advisory Board Center (to establish a Center for non‐embryonichuman stem cells) for Stem Cell and Regenerative Medicine, Case WesternUniversity, Cleveland, OHMember, CIHR Developmental Biology Grants CommitteeMember, Steering Committee of the Canada‐California Strategic InnovationPartnership on Cancer Stem CellsElected Vice‐President, President‐Elect and President, International Society forExperimental HematologyPanel Member, MSFHR Biomedical Postdoc Fellowship Review CommitteeNIH‐NHLBI Peer Review Panel Member, Special Emphasis Panel forMyelodysplastic Syndrome (RFA HL‐04‐033) and Myeloproliferative Disorders(RFA HL‐04‐034) Columbia, MDMember, Medical Genetics Graduate Program Advisory CommitteeMember, Genetics Graduate Program Advisory CommitteeMember, Pathology & Laboratory Medicine Promotions Committee, UBCMember, UBC Faculty of Medicine Nominating CommitteeMember, CIHR Genetics Review PanelMember, Board of Directors, National Cancer Institute of CanadaMember, American Society of Hematology Scientific Committee on Stem CellsAdvisory Board Member, International Society of Stem Cell ResearchSpecial Emphasis Panel, NHLBI, Washington DCMember, Radiation Safety Committee, BCCAMember, MEDG Teaching Award CommitteeMember, Planning Committee for Genetics Graduate Program, UBCMember, MSFHR Studentship Review CommitteeMember, CIHR Genetics Review PanelMember, BC Cancer Agency Tumour Site Leadership CouncilMember, International Society of Cellular Therapy Advisory BoardMember, NCIC Immunology Grants Panel154
Biennial Research Report 2005 ‐2006Current Research Projects 31. Activation and proliferation of purified hemopoietic stem cellsPI: P LansdorpNIH$187,500 (2005)$187,500 (2006)$595,758 (2002‐2007)This project examines the role of telomerase and telomeres incontrolling blood cell production throughout life. This projectwill test the hypothesis that the replication history ofhematopoietic stem cells is traceable by examining telomerelength.2. A phase I study of DT388IL3 fusion protein in patients with relapsed and refractory acute myeloidleukemiaPI: D HoggeLeukemia Research Fund of Canada$43,500 (2005)$43,500 (2006)$87,000 (2004‐2006)The goal of this study is to assess dosage and toxicity of asterilized recombinant diphtheria fusion protein – DT388IL3 – ina clinical trial of patients with acute myeloid leukemia.TERRY FOX LABORATORY3. A novel transplant protocol for chronic myelogenous leukemiaPI: A Eaves, C Eaves, M de Lima(MD Anderson)NIH$67,500 (2005)$132,500 (2004‐2006)This project will evaluate three purging methods to selectivelyeliminate chronic myelogenous leukemia stem cells ex vivo.4. A quantitative and comprehensive atlas of gene expression in mouse development ‐ GenomeCanada Competition II awardCo‐PI: M Marra, P HoodlessGenome Canada5. Bioinformatic standards for flow cytometryPI: R BrinkmanCo‐PI: C SmithNIH$220,000 (2005)$220,000 (2006)$1,100,000 (2005‐2010)For project description see Genome Sciences CentreThis project is a multidisciplinary collaboration focused ondeveloping data exchange standards for flow cytometry. Thescope of this project includes development of an ontology, a database schema, statistical and visual analysis tools, and a gatingstandard in the Extensible Markup Language (XML).6. Biology of cancer: Follicular lymphoma as a model of cancer progressionPI: J ConnorsCo‐I: A WengNCIC PPG7. Cancer Genomics – Genome Canada Competition I awardCo‐PI: V Ling, M Marra, C EavesCo‐I: K Humphries, P Lansdorp, etal.Genome Canada/ Province of BCFor project description see Pathology and Laboratory Medicine.For project description see Cancer Genetics & DevelopmentalBiology.3 Key to abbreviations: PI = Principal Investigator, Co‐I = Co‐investigator; CIHR* = Funding Institution; $150,000 (2005‐2007) = Total Project Funding for Given Years (*see pages 16‐17 for a list of acronyms)155
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Biennial Research Report 2005 ‐2006Current Research Projects 31. Activation and proliferation of purified hemopoietic stem cellsPI: P LansdorpNIH$187,500 (2005)$187,500 (2006)$595,758 (2002‐2007)This project examines the role of telomerase and telomeres incontrolling blood cell production throughout life. This projectwill test the hypothesis that the replication history ofhematopoietic stem cells is traceable by examining telomerelength.2. A phase I study of DT388IL3 fusion protein in patients with relapsed and refractory acute myeloidleukemiaPI: D HoggeLeukemia Research Fund of Canada$43,500 (2005)$43,500 (2006)$87,000 (2004‐2006)The goal of this study is to assess dosage and toxicity of asterilized recombinant diphtheria fusion protein – DT388IL3 – ina clinical trial of patients with acute myeloid leukemia.TERRY FOX LABORATORY3. A novel transplant protocol for chronic myelogenous leukemiaPI: A Eaves, C Eaves, M de Lima(MD Anderson)NIH$67,500 (2005)$132,500 (2004‐2006)This project will evaluate three purging methods to selectivelyeliminate chronic myelogenous leukemia stem cells ex vivo.4. A quantitative and comprehensive atlas of gene expression in mouse development ‐ GenomeCanada Competition II awardCo‐PI: M Marra, P HoodlessGenome Canada5. Bioinformatic standards for flow cytometryPI: R BrinkmanCo‐PI: C SmithNIH$220,000 (2005)$220,000 (2006)$1,100,000 (2005‐2010)For project description see Genome Sciences CentreThis project is a multidisciplinary collaboration focused ondeveloping data exchange standards for flow cytometry. Thescope of this project includes development of an ontology, a database schema, statistical and visual analysis tools, and a gatingstandard in the Extensible Markup Language (XML).6. Biology of cancer: Follicular lymphoma as a model of cancer progressionPI: J ConnorsCo‐I: A WengNCIC PPG7. <strong>Cancer</strong> Genomics – Genome Canada Competition I awardCo‐PI: V Ling, M Marra, C EavesCo‐I: K Humphries, P Lansdorp, etal.Genome Canada/ Province of <strong>BC</strong>For project description see Pathology and <strong>Laboratory</strong> Medicine.For project description see <strong>Cancer</strong> Genetics & DevelopmentalBiology.3 Key to abbreviations: PI = Principal Investigator, Co‐I = Co‐investigator; CIHR* = Funding Institution; $150,000 (2005‐2007) = Total Project Funding for Given Years (*see pages 16‐17 for a list of acronyms)155
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