Terry Fox Laboratory - BC Cancer Agency

British Columbia Cancer AgencyTERRY FOX LABORATORY46. Stem cells for the treatment of bone marrow failurePI: P LansdorpCo‐I: K Humphries, C EavesCIHR team grant$490,225 (2005)$490,225 (2006)$2,451,125 (2005‐2010)47. The role of Ahi‐1 in human leukemogenesisPI: X JiangLeukemia Research Fund$50,000 (2005)$50,000 (2006)$200,000 (2004‐2008)The goals are to delineate the frequency and nature of mutations ingenes encoding telomerase components in patients with variousimmunological and hematological disorders and to develop noveltherapeutic options for patients.The aim is to gain new insights into the pathogenesis of humanleukemia that will ultimately lead to the development of a newrationally designed, molecularly targeted therapies by delineatingthe normal functions and transforming properties of a newcandidate oncogene (Ahi‐1).48. The role of novel oncogene (Ahi‐1) in the development of leukemiaPi: X JiangCancer Research Society$60,000 (2005)$60,000 (2006)$240,000 (2003‐2007)49. The role of SHIP in hemopoiesis and innate immunityPI: G KrystalNCIC$150,000 (2006)$750,000 (2005‐2010)The goal is to understand the molecular mechanisms of aberrantgene regulation and function that contribute to the development ofhuman leukemia ultimately, leading to the development of moreeffective, molecularly targeted therapies.This project will investigate how the SHIP protein regulates theactivity of different blood cells and their precursors.162