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<strong>The</strong> <strong>Royal</strong> <strong>Marsden</strong>Conclusions (1)– Some melanomas are dependent on signallingthrough certain pathways (cf. c-KIT in GIST andEGFR in NSCLC)– Molecular classification of melanoma is clinicallyrelevant– Further trials are needed to define safety, efficacy,biology and resistance– Tissue collection for genotyping and for research iscritical