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<strong>The</strong> <strong>Royal</strong> <strong>Marsden</strong>What about GNAQ and NRAS?– ~25% of patients with cutaneous melanoma haveNRAS mutations– ~80% of ocular melanomas have mutually exclusivemutations in GNAQ or GNA11– We do not know how to target these groupstherapeutically– Further work is neededVan Raamsdonk NEJM 2010
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