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<strong>The</strong> <strong>Royal</strong> <strong>Marsden</strong>BRAF: Breakthrough– Activating mutations of non-receptor TK BRAF in~50% of cutaneous melanomas– <strong>The</strong> (weak) BRAF inhibitor sorafenib is not active inthis setting– PLX4032 is a potent BRAF inhibitor– Data from the PLX4032 Phase I study and anextension cohort presented in 2009Flaherty et al. ASCO 2009 Abstract 9000Chapman et al. ECCO/ESMO 2009
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