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<strong>The</strong> <strong>Royal</strong> <strong>Marsden</strong>NICAM: A Phase II Trial of Nilotinib in c-KIT MutantAcral and Mucosal Melanoma– 9 centres around UK led from RMH/ICR– Subjects screened for c-KIT mutations (~120 over 2years)– Primary endpoint = PFS at 6 months (n=24 subjectswith mutations)– An important goal is to investigate biology (SamraTurajlic, Richard Marais ICR)