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<strong>The</strong> <strong>Royal</strong> <strong>Marsden</strong>Molecular classification of melanoma– Melanomas can be classified according mutuallyexclusive BRAF, NRAS and c-KIT mutations– Mucosal and acral melanomas have c-KIT mutations– c-KIT mutated in majority of GISTs– Prolonged survival with imatinib in GISTCurtin et al. N Engl J Med. 2005;353(20):2135-47.Curtin et al. J Clin Oncol. 2006;24(26):4340-6.
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