WET GRANULATION: PHYSICO â CHEMICAL EVALUATION AND ...

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Bulk densities for different granule size fractions:granule sizefractions 1 2 3 4 5 6 7bulk density(g/cm³) 0,548 0,555 0,562 0,650 0,643 0,655 0,554Dissoltion rate constant (k) is calculated from:ln(c ∞ –c t ) = ktc ∞ – the concentration when all the drug is dissolvedc t – the concentration of the drug at time tSimple regression procedure was performed using four different models:a) linear: y = a + bxb) exponential: y = e a+bxc) reciprocal: 1/y = a + bxd) multiplicative: y = a · x bThe values for granulation parameters represented the independent variablex and the values for tablet parameters are taken for dependent variable y. InTable 4 all the values for both variables are presented.
Correlation coefficients for each pair of tested parameters are presented in Table 5.Table 5: Correlation coefficients for different pairs of tested parameters.Independent Dependent variablesvariablesregressionmodelcrushingstrengthaveragemassliberationconstantfriabilityL 0,857 0,204 0,654 0,776granule E 0,841 0,198 0,545 0,803diameter R 0,822 0,192 0,416 0,817M 0,921 0,099 0,640 0,939L 0,892 0,153 0,753 0,939repose E 0,885 0,138 0,670 0,939angle R 0,872 0,123 0,562 0,928M 0,897 0,165 0,672 0,932L 0,534 0,025 0,454 0,786flow E 0,546 0,039 0,413 0,719rate R 0,554 0,052 0,360 0,650M – – – –Legend: L-linear model, E-exponential model, R-reciprocal model, M-multiplicative model
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Page 4 and 5: pressure (PSI, pounds per square in
Page 6 and 7: Average diameter of the granulation

WET GRANULATION: PHYSICO â CHEMICAL EVALUATION AND ...

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