Antimicrobial Use Guidelines (AMUG) version 21 - UW Health
Antimicrobial Use Guidelines (AMUG) version 21 - UW Health
Antimicrobial Use Guidelines (AMUG) version 21 - UW Health
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MOXIFLOXACINLevofloxacin and moxifloxacin are therapeutically interchangeable for respiratory tract infections at the <strong>UW</strong>HC wherePseudomonas is not suspected. Moxifloxacin is the current preferred choice.Usual DoseAdult: 400 mg Q24H IV/PO (<strong>UW</strong>HC cost/day IV $11.60; PO $2.51).Indications1. Community-acquired pneumonia caused by S pneumoniae, H influenza, H parainfluenzae, K pneumoniae, Mcatarrhalis, Chlamydia pneumoniae, Legionella pneumophila, or Mycoplasma pneumoniae (7- to 10-day regimen).2. Acute exacerbations of chronic bronchitis (5-day regimen).3. Sinusitis.4. Skin and skin-structure infections, uncomplicated5. As monotherapy, stepdown, for intra-abdominal infections.CommentsOral moxifloxacin has excellent bioavailability and is much less expensive than the IV form. The oral form should beused in any patient taking other oral medications or nutrition. <strong>Use</strong> of quinolones is generally contraindicated inchildren
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