Antimicrobial Use Guidelines (AMUG) version 21 - UW Health

Concurrent administration with penicillins results in antagonism of the antibiotic effect of the penicillin becausedoxycycline is a bacteriostatic drug and penicillins act on bacteria in an active growth phase.EFAVIRENZAlso a component of Atripla ®For up-to-date information on the use of antiretrovirals, consult an HIV expert or www.aidsinfo.nih.gov/EMTRICITABINE – nonformulary at UWHCAlso a component of the combination products Truvada ® and Atripla ®For up-to-date information on the use of antiretrovirals, consult an HIV expert or www.aidsinfo.nih.gov/ENFUVIRTIDE – nonformulary at UWHCFor up-to-date information on the use of antiretrovirals, consult an HIV expert or www.aidsinfo.nih.gov/EPZICOM ® -- see abacavir/lamivudineFor up-to-date information on the use of antiretrovirals, consult an HIV expert or www.aidsinfo.nih.gov/ERTAPENEM –requires ID approval.Usual DoseAdult: 1 g daily IV (UWHC cost/day $57.72).Pediatric: 3 mo-12 yr: 15 mg/kg Q12H, not to exceed 1 g/day; >13 years: 1 g Q24HIndications1. Complicated skin and skin-structure infections2. Complicated urinary tract infections3. Pelvic infections4. Community-acquired pneumonia5. Diabetic foot infections6. Intraabdominal infections7. Bloodstream infections due to susceptible organisms8. Infections caused by ESBL-producing Enterobacteriaceae9. Although approved for prophylaxis by the FDA for colorectal surgery, routine use for this indication at UWHC is stronglydiscouraged.CommentsInfuse over 30 minutes. Dose adjustment recommended in severe renal impairment. Patients with CrCl