Paola Grandi, PhD Birth Date - American Society of Gene & Cell ...

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2P01 NS40923-06 (Pollack) 02/26/08-02/28/13 50%NIH/NINDSNovel Strategies for Brain Tumor TherapyProject 3 (PI: Glorioso and Grandi) Novel Oncolytic HSV Vectors and Enhanced Anti-Tumor ActivityThe unifying hypothesis of this program project grant is that novel therapeutic approaches that take into accountthe unique features of CNS tumors will have utility for preventing tumor growth and inducing tumor regression.PENDINGNIH: 1R01 1A175052-01PI: Grandi PaolaEnhanced GBM Therapy Using a New Class of HSV Oncolytic VectorNIH P01 (Chiocca) Co-PI: GrandiProject 1: Circumventing Barriers to Effective Oncolytic Virotherapy of Neural TumorsPE-2011-02348974 Italian grant for researcher abroadRe-programming Human Cord and Peripheral Blood Cells to PluripotencyThis grantwill be reviewed at the NIHCOMPLETED5P01 NS40923-03 (PI : Pollack, co-PI Grandi) 07/01/02-05/31/07Program Project GrantProject 4 Vector Delivery to Modify the Brain Tumor Novel Strategies for Brain Tumor Therapy and itsMicroenvironmentThe overall goal of this program project is to further develop HSV non –replicative vectors for treatment GBM incombination with GV and gamma-kmifeD2007-0621 (Grandi) 10/15/07-10/15/08The Copeland foundationNovel HSV Oncolytic Vectors with Enhanced Efficacy for Treatment of Glioblastoma1R01 CA 119298-01 (Glorioso and Grandi) 12/01/05-11/30/10 10%NIH/NCI $333.213Glioma Gene Therapy Using Targeted OncolyticHSV Vectors4
In this proposal, experiments are outlined to explore methods to enhance the potency of HSV oncolytic vectorsthrough improved vector distribution within the tumor mass, the testing of additional mutant vector backboneswhose performance may be improved by enhanced and more specific intr-tumoral replication and through the useof additional transgenes that may be more effective in destruction of the tumor mass including locally infiltratingtumor cells into normal brain tissue. Throughout this investigation vector performance and tumor killing will beevaluated in combination with radiosurgery. We will use the performance of G207 as a benchmark with which tocompare any vector improvements.Presentations and Invited LecturesMonini P., de Lellis L., Lenette E. T., Rimessi P., GRANDI P., Franco M., Leone P., Lodi G.L., Rossi T., Levy J. A.,Rezza G., Cassai E., Ensoli B (1997). PCR detection of HHV-8 DNA in sperm and HHV-8 antibodies detection inimmunocompetent individuals from Italy. In: Acts of “Second International Conference on Human Herpesviruses 6, 7 and8Monini P., de Lellis L., Rimessi P., GRANDI P., Franco M., Leone L., Rosso R., Rossi T., Aiuti F., Lodi G. L., Ensoli B.and Cassai E (1997). Presence of HHV-8 DNA in semen of immunocompetent HIV-negative individuals from differentgeographical areas in Italy. In: Acts of “National AIDS Malignancy Conference". Bethesda, Marylan, 28-30 April 1997Caselli E, Balboni PG, Incorvaia C, Parmeggiani F, Borsato GM, Bozzini R, GRANDI P., Grossi MP, Manservigi R.(1999). Nuovi approcci per lo sviluppo di un vaccino anti-HSV-1: applicazione ed efficacia dell'immunizzazione geneticae/o perioculare basate sulla gB1s nel coniglio. . In: CNB3 - 3° Congresso Nazionale Biotecnologie. Urbino, Italy, 1-3luglio 1999Consorzio Interuniversitario Biotecnologie, p. 78-78Secchiero P., Bozzini P., GRANDI P., Balboni P.G., Caselli E., Argnani R., Colle V., Manservigi R (1999). La proteinaVP22 del virus dell’herpes: un nuovo modello per la terapia genica anti-HIV-1. In: 3° Congresso del ConsorzioInteruniversitario delle BiotecnologieGRANDI P., Secchiero P., Balboni PG e Manservigi R (2000). La proteina VP22 del virus dell’Herpes: un nuovo modelloper la terapia genica anti HIV-1. In: 28° Congresso Nazionale Società Italiana di MicrobiologiaGrandi PVettori ampliconi e VP22: un nuovo sistema di delivery basato sul virus dell’Herpes simplex.Ferrara, Italy, 10 December 20University ofGRANDI P., Secchiero P, Balboni PG, Zerbinati A, Brewis N, O’Hare P, Manservigi R. (2001). HSV-1 VP22 as a genetherapy approach for HIV. MOLECULAR THERAPY, ISSN: 1525-0024Manservigi R., Marconi P., Argnani R., GRANDI P., Balboni P.G (2001). Amplicon Vectors as a novel approach to HIV-1 vaccine development. Acts of . In: Third National Research Program on AIDSGrandi P. HSV-1 amplicon vector engineered for specific binding to pseudo his-tag receptor. Boston, MGH NeuroscienceDept. 10 April 2002Grandi P. HSV-1 amplicon vector engineered for specific binding to pseudo his-tag receptor. Boston, Harvard MedicalSchool Neuroscience Dept. 25 October 20025
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