Paola Grandi, PhD Birth Date - American Society of Gene & Cell ...
Paola Grandi, PhD Birth Date - American Society of Gene & Cell ...
Paola Grandi, PhD Birth Date - American Society of Gene & Cell ...
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HONORS1996 B.Sc. in Biology: degree with 110/110 cum laude from University <strong>of</strong> Ferrara;1997 M.Sc. in <strong>Gene</strong>tic: degree with distinction;2001 Ph.D degree with optimum from University <strong>of</strong> Ferrara;2001 Only fellowship for US study from University <strong>of</strong> Ferrara.2005 travel award for the best oral presentation at the International Herpesvirus Workshop, Turku, Finland.2012 Scientist <strong>of</strong> the month (march) from <strong>American</strong> <strong>Society</strong> for <strong>Gene</strong> and <strong>Cell</strong> therapy.Under revision:PUBLICATIONSLucia Mazzacurati, Marco Marzulli, Bonnie Reinhard, Yoshitaka Miagawa, Nino Chiocca, Joseph Glorioso, <strong>Paola</strong><strong>Grandi</strong>mir124-controlled HSV1 based oncolytic vecto for treatment <strong>of</strong> Glioblastoma Multiforme (Submitted cancer research)Publications in Scientific Journals:1. Uchida H, Chan J, Shrivastava I, Reinhart B, <strong>Grandi</strong> P, Glorioso JC, Cohen JB. Novel mutations in gB and gHcircumvent the requirement <strong>of</strong> known gD Receptors in herpes Simplex Virus 1 Entry and cell-to-cell spread. JVirol. 2013 Feb;87(3):1430-42. doi: 10.1128/JVI.02804-12. Epub 2012 Nov 14.2. Hiroaki Uchida, Marco Marzulli, William F. Goins, Janet Chan, Chang-Sook Hong, Lucia Mazzacurati, Ji Y.Yoo, Amy Haseley, Hiroshi Nakashima, Kenji Nakano, Hyunjung Baek, Heechung Kwon, Izumi Kumagai,Masahide Kuroki, Balveen Kaur, E. Antonio Chiocca, <strong>Paola</strong> <strong>Grandi</strong>, Justus B. Cohen, and Joseph C. Glorioso.Effective Treatment <strong>of</strong> an Orthotopic Xenograft Model <strong>of</strong> Human Glioblastoma Using an EGFR-RetargetedOncolytic Herpes Simplex Virus. Mol. Therapy 2012, Oct 163. Bonnie Reinhart, Lucia Mazzacurati, Adriana Forero, Chang-Sook Hong, Junichi Eguchi, Hideho Okada, WendyFellow, Ajay Niranjan, Justus Cohen, J. C. Glorioso and <strong>Paola</strong> <strong>Grandi</strong>. Inhibition <strong>of</strong> Indoleamine-2,3-Dioxygenase (IDO) in Glioblastoma <strong>Cell</strong>s by Oncolytic Herpes Simplex Virus. Advances in Virology. 2012;2012:8154654. <strong>Grandi</strong> P, Fernandez J, Szentirmai O, Carter R, Gianni D, Sena-Esteves M, Breakefield XO. Targeting HSV-1virions for specific binding to epidermal growth factor receptor-vIII-bearing tumor cells. <strong>Gene</strong> Ther. 2010Sep;17(9):655-63. Epub 2010 May 28.5. Uchida H, Chan J, Goins WF, <strong>Grandi</strong> P, Kumagai I. Cohen JB, and Glorioso, JC. A double mutation inglycoprotein B compensates for ineffective gD-dependent initiation <strong>of</strong> herpes simplex virus type 1 infection. JVirol. Dec; 84(23): 12200-9, 2010.6. Hong CS, Fellows W, Niranjan A, Alber S, Watkins S, Cohen JB, Glorioso JC, <strong>Grandi</strong> P. Ectopic matrixmetalloproteinase-9 expression in human brain tumor cells enhances oncolytic HSV vector infection. <strong>Gene</strong> Ther.Oct; 17(10): 1200-5, 2010.7. Frampton AR Jr, Uchida H, von Einem J, Goins WF, <strong>Grandi</strong> P, Cohen JB, Osterrieder N, Glorioso JC. Equineherpesvirus type 1 (EHV-1) utilizes microtubules, dynein, and ROCK1 to productively infect cells. VetMicrobiol. 2010 Feb 24;141(1-2):12-21. Epub 2009 Aug 8.8. <strong>Grandi</strong> P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC. Design and application <strong>of</strong> oncolytic HSVvectors for glioblastoma therapy. Expert Rev Neurother. 2009 Apr;9(4):505-179. Uchida H, Shah WA, Ozuer A, Frampton AR Jr, Goins WF, <strong>Grandi</strong> P, Cohen JB, Glorioso JC. <strong>Gene</strong>ration <strong>of</strong>herpesvirus entry mediator (HVEM)-restricted herpes simplex virus type 1 mutant viruses: resistance <strong>of</strong> HVEMexpressingcells and identification <strong>of</strong> mutations that rescue nectin-1 recognition. J Virol. 2009 Apr;83(7):2951-61.10. H. Li, D. Krisky, P. <strong>Grandi</strong>, R. Baskaran, J. C. Glorioso . HSV-1 ICP0 activates Chk2 to induce G2/M arrest andto enhance virus growth. Virology. 2008 May 25;375(1):13-232