VIRAL INFECTION - Faculty of Medicine
VIRAL INFECTION - Faculty of Medicine VIRAL INFECTION - Faculty of Medicine
Intracytoplasmic inclusion bodies(molluscum bodies)PathogenesisPoliovirus infects oropharynx secreted in saliva andswallowMultiplies in intestinal mucosa and lymph nodesHematogenous spreadingInvade to CNS and replicate in spinal cord (spinalpoliomyelitis), or brain stem (bulbar poliomyelitis)* Virus destroys motor neuron in anterior horn ofspinal cord or brain stem*PoliomyelitisCentral nervous system• Clinical features- flaccid paralysis- muscle atrophy- hyporeflexiaPoliovirus• Causes poliomyelitis• Transmitted by fecal-oral route• Most asymptomatic• 1/100 of infected patientsdisease(spinal poliomyelitis, bulbar poliomyelitis)Rabies virus• Cause of rabies (encephalitis)• Transmitted by saliva of dog or cat bites• Clinical:- malaise, headache, fever, dysphagiafallowed by period of acute neurologicsymptom including disorientation,hallucination, seizure, coma and deadfrom res. failure
Rabies virus• Post-exposure prophylaxis: combinedimmune serum and vaccine• High mortality rateArbo viral encephalitis virus• Japanese B caused by encephalitis• Animal host : pig• Carrier : Culex mosquitoes• Clinical : confusion, seizure, coma• Pathology : mononuclear cells aroundvessels, necrosis of neuron and braintissuePathogenesisRabies virus multiplies at site of local bitetravel to CNS through the peripheral nervesTHE ENDreplicates in neurons of CNSClinical symptomNegri bodiesIntracytoplasmic inclusion in neuron
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- Page 16 and 17: Cytomegalovirus (CMV)• Produce a
- Page 18 and 19: Human Immunodeficiency Virus(HIV)
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Intracytoplasmic inclusion bodies(molluscum bodies)PathogenesisPoliovirus infects oropharynx secreted in saliva andswallowMultiplies in intestinal mucosa and lymph nodesHematogenous spreadingInvade to CNS and replicate in spinal cord (spinalpoliomyelitis), or brain stem (bulbar poliomyelitis)* Virus destroys motor neuron in anterior horn <strong>of</strong>spinal cord or brain stem*PoliomyelitisCentral nervous system• Clinical features- flaccid paralysis- muscle atrophy- hyporeflexiaPoliovirus• Causes poliomyelitis• Transmitted by fecal-oral route• Most asymptomatic• 1/100 <strong>of</strong> infected patientsdisease(spinal poliomyelitis, bulbar poliomyelitis)Rabies virus• Cause <strong>of</strong> rabies (encephalitis)• Transmitted by saliva <strong>of</strong> dog or cat bites• Clinical:- malaise, headache, fever, dysphagiafallowed by period <strong>of</strong> acute neurologicsymptom including disorientation,hallucination, seizure, coma and deadfrom res. failure
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