VIRAL INFECTION - Faculty of Medicine
VIRAL INFECTION - Faculty of Medicine VIRAL INFECTION - Faculty of Medicine
Recurrent herpes simplex infectionHSV (gingivostomatitis)Triggers include fever, sunlight, localtrauma, menses, emotional stressSeen most commonly as cold soresProdrome of localized burning, itchingbefore eruption of grouped vesiclesHerpes simplex virusHSV (genital herpes)• Gross:- group of intraepithelial vesicles(blisters) and frequently crust covering- may be ulcer• Pathology:- pink to purple, glassy intranuclearinclusion (Cowdry type A)- mononucleated or multinucleated cellsHSV (cold sores)HSVglassy intranuclear inclusion (mononucleated or multinucleated cells)
Pathogenesis of HSVInitial infection in skin or mucous membranetravel along sensory nerve ending and retrograde axonalflow to neuron in dorsal root ganglia (latent infection)reactivate of latent infected neuron (eg. stress, fever, UV)Varicella zoster virus (VZV)• Cause of chickenpox, herpes zoster(shingles)• Incubation period ranges from 10-20 days• Transmitted by inhalation of airbornerespiratory droplets from an infected hostor direct contactnewly replicated virus is transported anterograde to a site ator near portal of entry into body causing localized vesiclesPathogenesis of HSVVaricella zoster virus (VZV)• Primary acute infection of VZV:“chickenpox”• Reactivation of latent VZV: “shingles orherpes zoster” distributes to sensorynervesNeonatal herpes infection• Infected fetus by contact vaginal secretioncontains viruses• Clinical features- mucocutaneous vesicles- virus spread to other organs eg. brain,liver, lung• High mortality rateVaricella (chickenpox)• Clinical : fever, diffuse vesicle on skin andmucous membrane• Complications : secondary bacterial skininfections, pneumonia, hepatitis,encephalitis, Reye syndrome• Severe in the immunocompromised host• Tx: Varicella-zoster immunogloblin
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- Page 16 and 17: Cytomegalovirus (CMV)• Produce a
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Recurrent herpes simplex infectionHSV (gingivostomatitis)Triggers include fever, sunlight, localtrauma, menses, emotional stressSeen most commonly as cold soresProdrome <strong>of</strong> localized burning, itchingbefore eruption <strong>of</strong> grouped vesiclesHerpes simplex virusHSV (genital herpes)• Gross:- group <strong>of</strong> intraepithelial vesicles(blisters) and frequently crust covering- may be ulcer• Pathology:- pink to purple, glassy intranuclearinclusion (Cowdry type A)- mononucleated or multinucleated cellsHSV (cold sores)HSVglassy intranuclear inclusion (mononucleated or multinucleated cells)
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