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. 生 命 科 學 組 Division of Life Sciences 苷 酶 1 1 1,2 1 *1 *1,21 2 X- 苷 酶 X- 苷 酶 苷 酶 Tamiflu 酶 苷 酶 pHK i - 苷 酶 苷 酶 TmF1-9X-Ki1T47-M55V269-G273G297-H3002 8 8 -C-TmF-1K i =16nMTmF-2K i *=0.47pMTmF-9K i =6MK M =50M46-65266-275TmF-9TmF-13TmF-9Y64E266TmF-1E49-H268Y64-E266L50-V2694D224E2661 110TmF10- 苷 酶 K i 0.40nM89-C1-32
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