UPDATES ON MANAGEMENT OF IRRITABLE BOWEL SYNDROME
UPDATES ON MANAGEMENT OF IRRITABLE BOWEL SYNDROME
UPDATES ON MANAGEMENT OF IRRITABLE BOWEL SYNDROME
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Lubiprostone• Selective C‐2 chloride channel activator• Enhance chloride rich intestinal secretion• FDA approved for treatment of IBS–C since 2008• 2 RCTs 2009 lubiprostone 8 mcg vs. placebo twice daily for 12 weeks Percentage of responders : 17.9% vs. 10.1%, P=0.001 Improve constipation and global symptoms• GOR : 1BClinical trial: lubiprostone in patients with constipation‐associated irritablebowel syndrome‐‐results of two randomized, placebo‐controlled studiesAliment Pharmacol Ther. 2009
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