UPDATES ON MANAGEMENT OF IRRITABLE BOWEL SYNDROME
UPDATES ON MANAGEMENT OF IRRITABLE BOWEL SYNDROME
UPDATES ON MANAGEMENT OF IRRITABLE BOWEL SYNDROME
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Anti‐depressantsTCA• Postulated mechanisms Antihyperalgesia by blockade of norepinephrine reuptake Slow intestinal transit time ‐> (may exacerbate constipation )• 1 Meta‐analysis 32 RCTs RR of IBS symptoms persisting 0.66, 95% CI 0.57 to 0.78 TCA superior to placebo (NNT –4 , 95% CI3‐8 ) Similar Tx effect with SSRI• S/E : Dry mouth , dizziness ,constipationEfficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematicreview and meta‐analysis. Ford AC; Talley NJ; Schoenfeld PS; Quigley EM; Moayyedi P Gut. 2009
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