UPDATES ON MANAGEMENT OF IRRITABLE BOWEL SYNDROME
UPDATES ON MANAGEMENT OF IRRITABLE BOWEL SYNDROME
UPDATES ON MANAGEMENT OF IRRITABLE BOWEL SYNDROME
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Mucosal Inflammation• Up to 1/3 of individuals suffered with bacterial enteritisgo on to develop more chronic GI symptoms• 10 to 30 % of patients after acute GE• Low grade inflammation• Change in gut immune system : increase in enteroendocrinecells, T lymphocytes, and gut permeability• Microscopic inflammationIncrease lymphocytic infiltration in myenteric plexusActivated mast cells infiltration• Role remains unclear, only small number of patientsstudiedPostinfectious irritable bowel syndrome--a meta-analysis. Am J Gastroenterol 2006
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