UPDATES ON MANAGEMENT OF IRRITABLE BOWEL SYNDROME
UPDATES ON MANAGEMENT OF IRRITABLE BOWEL SYNDROME
UPDATES ON MANAGEMENT OF IRRITABLE BOWEL SYNDROME
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Visceral Hypersensitivity andBrain‐gut Interactions• Perception in the GI tract results from stimulation of variouschemoreceptors and mechanoreceptors in the gut wall.Enhanced perception of visceral stimuli leads to abdominalpain• Abnormalities in brain‐gut (CNS‐ENS ) axisDysmodulationAltered biochemical axisRecent work using PET scan and functional MRI identifiedabnormalities in brain activation in patients who had IBS versuscontrols• Evolving evidence has implicated several neuromodulators,including serotonin, in the normal function of ENS
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