MD-PhDProgram - Harvard Medical School - Harvard University

HARVARD MEDICAL SCHOOLMD-PhDProgramnewslettersummer 2007 ■ vol. 18 ■ no. 2If there is too much introspection duringgraduate school, and too little duringthe clinical rotations of medical school,the end of MD-PhD training is an idealtime to catch our collective breath. Withthe Scientist peering expectantly over oneshoulder and the Physician tapping impatientlyon the other, an MD-PhD studentcan be as disoriented as Alice inWonderland when traveling between thelab and the wards. We squirmed whenasked to solve differential equations aftertwo years of medical school (even inHST), and we squirmed again whenasked to recall the appropriate antibioticfor pneumonia after N years of graduateschool. But even after a crash course withGenes V (or Genes VIII for the youngergeneration) and a furtive speed-read courtesy of Up-to-date, we realized that theunsettled feeling might have deeper psychological roots.When Nobel Laureate Paul Nurse was invited for lunch with the MD-PhD students,he pointed out that physicians are trained to be confident and certain in their decisions,while scientists are trained to be skeptical and selfdoubting.One member of the Class of 2007 argues that theContents42007 GRADUATES6SOCIETY OLYMPICS7NEW CLASS8LEADERS IN BIOMEDICINE9CARTOON BY RAPOPORT10FOR THE RECORDSplit PersonalityTHE TRAINING OF A PHYSICIAN-SCIENTISTby Irene Chenpsychological difference between scientist and doctor is actuallyessential, while the MD-PhD training offers a perspectivethat bridges the gap.SOPHIE CURRIER: “The attitude of each world is appropriatefor the task at hand. Physicians, especially surgeons, arerequired to make rapid decisions based on the knowledgeavailable, which will always be somewhat inadequate.However, a scientist [discovers] knowledge and must put eachstatement that he or she makes through a long series of “qual-continued on page 2Dr. Stephen BlacklowAppointed to Lead theMD-PhD ProgramWe are delighted to announce thatDr. Stephen Blacklow has assumeddirectorship of the MD-PhDProgram, succeeding Dr. ChristopherA. Walsh, who stepped down as thedirector to take on new responsibilitiesas the chair ofthe Department ofGenetics atChildren’s Hospital.Dr. Blacklow hasbeen devoted to theMD-PhD Program formany years, first asa member of theadmissions committee and as thedesignated faculty advisor for MD-PhD students in the PeabodySociety. Since 2004, he has servedas a member of the program’sExecutive Committee, directed thesummer course for entering MD-PhDstudents, and in 2006 became directorof the Subcommittee ofAdmissions for the program. He iswell-known to the students andenters his new role with enthusiasmand commitment to student mentoringand guidance as a top priority.Dr. Blacklow is a board-certifiedpathologist at the Brigham andWomen’s Hospital, where he hascontinued on page 3

Blacklow Named DirectorCONTINUED FROM PAGE 1directed a research laboratory since1998. Dr. Blacklow’s laboratory focuseson the relationship between structureand function in proteins of the low-densitylipoprotein receptor family and inhuman Notch proteins, achieving internationalrecognition as a leader in mechanisticand structural studies of thesetwo classes of receptor proteins.The MD-PhD Program salutes Dr. Joseph B. Martin whostepped down from his role as Dean of the Faculty ofMedicine for the past 10 years. We are grateful for Dr.Martin’s active participation in our program and hisgenerous support of the MD-PhD students during hisdecade long deanship. Shown above are studentspresenting Dr. Martin with the prize winning cakebaked in his honor during the Society Olympics.edge, with sometimes no attention or expectation paid to underlyingmechanisms or explanations. I am sure this will change as I makethe transition from student to resident, and the body of informationbecomes progressively more focused and pertinent.”Many of us hope that as we continue to grow and learn, we mayeventually combine the depth of scientific inquiry with the breadthof medical knowledge. In Erwin Schrodinger’s famous example ofquantum mechanics, a cat is placed in a box with a canister of poisonousgas that is set up such that the radioactive decay of a singleparticle will open the canister. If the decay event occurs, the catwill die; as long as it fails to occur, the cat lives. In the absence ofan observer, the particle and the cat exist as asuperposition of both possible states. An MD-PhD student is much like Schrodinger’s cat, neitherscientist nor physician alone, but in a mixedstate of being that cannot be easily categorized.May the cultural differences between science andmedicine be a source of energy and creativity asIRENE CHENwe move ahead.We welcome Dr. Blacklow to his newrole as director of the MD-PhD Programof Harvard Medical School, and look forwardto the contributions of his leadership,experience, and insight will bringto our community.In welcoming the new MD-PhD studentsat orientation on July 5, 2007, Dr.Blacklow stated, “I look forward to gettingto know each of you as your studiesprogress, and am delighted to beginserving you as the new director of theMD-PhD Program. The program hasnever been stronger, thanks to the superleadership of the two previous directors,Chris Walsh and Nancy Andrews, and Ihope to build on the foundation theyhave put in place over the past severalyears. In particular, my top priority willbe to continue to find ways to integratethe programs of medical and graduatestudy to facilitate students in makingprogress towards timely completion oftheir dual degrees. I would also like tohear from all of the students to learnwhether you have any suggestions orideas about how we can make the programeven better in the coming years.”HARVARD MD-PHD PROGRAM newsletter3

Toasting the 2007 GraduatesThe MD-PhD Program held its annual Spring Dinner in honor of thisyear’s 28 MD-PhD graduates on June 5, 2007. The MD-PhD class isthe largest number in the program’s history. Drs. Nancy Andrewsand Joseph Martin gave the traditional champagne toasts to thegraduates following introductions by Drs. Stephen Blacklow andAllan Brandt. Graduate speakers included Drs. Rita Khodosh, DouglasRubinson and Benjamin Sommers. Dr. Christopher A. Walsh alsogave a special tribute to Dr. Martin who stepped down this year asthe Dean. The evening was filled with special moments as grandparents,parents, students, faculty and staff celebrated the achievementsof the MD-PhD Class of 2007.4HARVARD MD-PHD PROGRAM newsletter

notesLeft: Onyi Iweala at AsakusaKannon Temple, the oldestBuddhist temple in Tokyo.Right: From left to right, MilenaAndzelm, Jonathan Abraham,Yin Ren, Karolina Maciag andCameron Sadegh.H. pylori to induce gastritis in orderto demonstrate that H. pylori was apathogen and a causative agent ofgastric ulcers.EIGHT SECOND-YEAR MD-PhD students presented posters at the 22nd AnnualMD-PhD Student Conference held July 27-29, 2007 in Keystone, Colorado hostedby the MSTP at the University of Colorado at Denver and Health Sciences.The conference offers a forum for MD-PhD students from around the countryto share research, meet and hear distinguished speakers and enjoy the RockyMountains. This year’s featured speakers were Peter Agre, MD, Huda Zoghbi,MD, David Baltimore, PhD, Mark Saltzman, PhD, and Polly Matzinger, PhD.Students attending were Jonathan Abraham, Milena Andzelm, CameronSadegh, Erin, Chen, Yin Ren, Jenny Yang, Stephen Huffaker, andKarolina Maciag.Students Travel to High PlacesONYI IWEALA attended the 13th International Congressof Mucosal Immunology: “Not All Quiet on the Frontlineof Mucosal Immunology” this past July in Tokyo, Japan.She reports “It was an action packed meeting with presentationsfrom many heavyweights from the field of mucosalimmunology.The meeting provided superb coverage of the fieldof mucosal immunology, including various sessions onthe development of mucosally delivered vaccines, a newlyemerging global strategy for improving vaccine efficacyand vaccine coverage. I had the opportunity to presentsome of my thesis work on the impact of parasitichelminth infections on the efficacy of oral vaccination.Talks of note included a standing room only lectureby Maria Rescigno on role of intestinal epithelial cell anddendritic cell mediators in maintaining the immunoquiescientenvironment in the GI tract in the face of constantexposure to microbial products and foreign dietary proteins;a lecture by T-regulatory cell maven ShimonSakaguchi that introduced folate receptor 4 as a newmarker for identifying activated T regulatory cells; and alecture by Nobel Laureate Barry J. Marshall in which hedescribed in detail his notorious self experiment—drinkingHARVARD MD-PHD PROGRAM newsletter9

For the RecordPhDs completedMilan Bajmoczi, Cannon, BBS-Biological Chemistry andMolecular Pharmacology (DMS) at Harvard University. [David E.Golan, M.D., Ph.D.] Internalization of Pseudomonas aeruginosaby Non-polarized and Polarized Epithelial Cells: a CFTR- andCaveolin-1-dependent Process (5/07).Brinda Balakrishnan, HST, Medical Engineering and MedicalPhysics at MIT. [Elazer R. Edelman, M.D., Ph.D.] ComputationalModeling of Local Intravascular Drug Delivery (3/07).Kyle K-H. Farh, HST, Biology at MIT. [David P. Bartel, Ph.D.]Targeting and Function of Mammalian MicroRNAs (6/07).Adam A.L. Friedman, HST, BBS-Genetics (DMS) at HarvardUniversity. [Norbert Perrimon, Ph.D.] Genomic dissection ofreceptor tyrosine kinase activation of extracellular signal-regulatedkinase in Drosophila (5/07).Lilit Garibyan, Holmes, BBS-Pathology (DMS) at HarvardUniversity. [Raif S. Geha, M.D.] The Role of TACI Mutations inCommon Variable Immunodeficiency (7/07).Todd M. Herrington, HST, Neuroscience(DMS) at Harvard University. [John A. Assad,Ph.D.] Attentional Shifts in Parietal Cortex andBehavior (6/07).Arindel S. Maharaj, Peabody, BBS-Pathology(DMS) at Harvard University. [Patricia A.D’Amore, Ph.D.] Vascular Endothelial GrowthFactor is Required for Vascular and TissueHomeostasis (6/07).Anthony A. Philippakis, HST, Biophysics atHarvard University. [Martha L. Bulyk, Ph.D.]An Integrated Computational Approach for theDetermination of Metazoan Cis RegulatoryCodes and Cis Regulatory Modules (5/07).Arindel S. Maharajat his PhD defensein June.Sashank K. Reddy, HST, Biophysics at Harvard University. [Marc W.Kirschner, Ph.D.] Ubiquitination by the Anaphase-Promoting ComplexDrives Spindle Checkpoint Inactivation (5/07).Daniel P. Seeburg, HST, Biology at MIT. [Morgan H. Sheng, Ph.D.] TheRole of Polo-like kinase 2 in Synaptic Function and Plasticity (5/07).Erica Seiguer, Cannon, Health Policy at Harvard University. [Richard G.Frank, Ph.D.] Innovation and Incentives in Pharmaceutical Research andDevelopment (5/07).Elizabeth H. Stover, HST, BBS-Genetics (DMS)at Harvard University. [D. Gary Gilliland, M.D.,Ph.D.] FIP1L1-PDGFRalpha, a tyrosine kinasefusion protein involved in chronic eosinophilicleukemia (5/07).Lilit Garibyan and her mentor, Raif S. Geha, MD, followingher PhD defense seminar in July.Zuzana Tothova, HST, BBS-Genetics (DMS) atHarvard University. [D. Gary Gilliland, M.D.,Ph.D.] The Role of Forkhead TranscriptionFactors in Hematopoiesis and Leukemogenesis(5/07).Zuzana Tothova at herPhD defense in May.Raj K. Gopal, Castle, Neuroscience (DMS) at Harvard University.[Bruce A. Yankner, M.D., Ph.D.] Regulation of DNA Double-Strand Break Repair by Parkin (6/07).Clara Y. Han, Holmes, Medical Anthropology at HarvardUniversity. [Arthur M. Kleinman, M.D.] Life in Debt: Depressionand Survival in Chile’s Market Democracy (5/07).Marc N. Wein, Holmes, Immunology (DMS) at Harvard University.[Laurie H. Glimcher, M.D.] Regulation of Immunobiology and SkeletalBiology by the Zinc Finger Adaptor Protein Schnurri-3 (6/07).Shannon C. Wieland, Cannon, Mathematics at MIT. [Bonnie Berger,Ph.D.] Computational, Statistical and Graph-Theoretical Methods forDisease Mapping and Cluster Detection (6/07).10 HARVARD MD-PHD PROGRAM newsletterHEALTH MEDICAL SCIENTIST TRAINING PROGRAM GRANT T32-GM07753-27.THIS NEWSLETTER IS SUPPORTED IN PART BY THE NATIONAL INSTITUTES OF

Publications (after March 7 2007)Begun J, Gaiani JM, Rohde H, Mack D, Calderwood SB, Ausubel FM, Sifri CD.Staphylococcal Biofilm Exopolysaccharide Protects against Caenorhabditis elegans ImmuneDefenses. PLoS Pathog. 2007 Apr 20;3(4):e57 [Epub ahead of print]Hughes ME, Bortnick R, Tsubouchi A, Baumer P, Kondo M, Uemura T, Schmucker D.Homophilic Dscam interactions control complex dendrite morphogenesis. Neuron. 2007May 3;54(3):417-27.Jinushi M, Nakazaki Y, Dougan M, Carrasco DR, Mihm M, Dranoff G. MFG-E8-mediateduptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF.J Clin Invest. 2007 Jun 7; [Epub ahead of print]Enzler T, Gillessen S, Dougan M, Allison JP, Neuberg D, Oble DA, Mihm M, Dranoff G.Functional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3contribute to insulitis and destruction of {beta}-cells. Blood. 2007 May 4; [Epubahead of print]Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, Bernstein BE,Jaenisch R. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.Nature. 2007 Jun 6; [Epub ahead of print]Garibyan L, Lobito AA, Siegel RM, Call ME, Wucherpfennig KW, and Geha RS. Ligandindependent preassociation is required for the dominant negative effect of a TACI mutantthat disrupts ligand binding. J Clin Invest. 2007 Jun;117(6):1550-7.Castigli E, Wilson SA, Garibyan L, Rachid R, Bonilla F, Schneider L, Geha RS. Update onTNFRSF13B/TACI mutations in CVID and IgA deficiency. Nat Genet. 2007 Apr;39(4):430-1.Mitoma J, Bao X, Petryanik B, Schaerli P, Gauguet JM, Yu SY, Kawashima H, Saito H,Ohtsubo K, Marth JD, Khoo KH, von Andrian UH, Lowe JB, Fukuda M. Criticalfunctions of N-glycans in L-selectin-mediated lymphocyte homing and recruitment. NatImmunol. 2007 Apr;8(4):409-18. Epub 2007 Mar 4.Greenland JR, Geiben R, Ghosh S, Pastor WA, Letvin NL. Plasmid DNA vaccine-elicitedcellular immune responses limit in vivo vaccine antigen expression through Fas-mediatedapoptosis. J Immunol. 2007 May 1;178(9):5652-8.Greenland JR, Letvin NL. Chemical adjuvants for plasmid DNA vaccines. Vaccine. 2007 May10;25(19):3731-41. Epub 2007 Feb 20.Hovav AH, Cayabyab MJ, Panas MW, Santra S, Greenland J, Geiben R, Haynes BF, JacobsWR Jr, Letvin NL. Rapid memory CD8+ T-lymphocyte induction through priming withrecombinant Mycobacterium smegmatis. J Virol. 2007 Jan;81(1):74-83. Epub 2006 Oct 18.Mapelli M, Filipp FV, Rancati G, Massimiliano L, Nezi L, Stier G, Hagan RS, Confalonieri S,Piatti S, Sattler M, Musacchio A. Determinants of conformational dimerization of Mad2 andits inhibition by p31comet. EMBO J. 2006 Mar 22;25(6):1273-84. Epub 2006 Mar 9.Hanna J, Meides A, Zhang DP, Finley D. A ubiquitin stress response induces altered proteasomecomposition. Cell. 2007 May 18;129(4):747-59.Hanna J, Finley D. A proteasome for all occasions. FEBS Lett. 2007 Mar 30; [Epub ahead ofprint]Hauser AE, Junt T, Mempel TR, Sneddon MW, Kleinstein SH, Henrickson SE, von AndrianUH, Shlomchik MJ, Haberman AM. Definition of germinal-center B cell migration in vivoreveals predominant intrazonal circulation patterns. Immunity. 2007 May;26(5):655-67.Henrickson SE, von Andrian UH. Single-cell dynamics of T-cell priming. Curr OpinImmunol. 2007 Jun;19(3):249-58. Epub 2007 Apr 12.Henrickson SE, Hartmann EM, Ott G., Rosenwald A. Gene expression profiling in malignantlymphomas. Adv Exp Med Biol. 2007;593:134-46. Review.Meyer-Lindenberg A, Straub RE, Lipska BK, Verchinski BA, Goldberg T, Callicott JH, EganMF, Huffaker SS, Mattay VS, Kolachana B, Kleinman JE, Weinberger DR. Genetic evidenceimplicating DARPP-32 in human frontostriatal structure, function, and cognition. J ClinInvest. 2007 Mar; 117(3):672-82. Epub 2007 Feb 8.Tkachev D, Mimmack ML, Huffaker SJ, Ryan M, Bahn S. Further evidence for alteredmyelin biosynthesis and glutamatergic dysfunction in schizophrenia. Int JNeuropsychopharmacol. 2007 Feb 12;:1-7 [Epub ahead of print]Koduri V, Blacklow SC. Requirement for natively unstructured regions of mesoderm developmentcandidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation.Biochemistry. 2007 Jun 5;46(22):6570-7. Epub 2007 May 9.Cavalieri D, Castagnini C, Toti S, Maciag K, Kelder T, Gambineri L, Angioli S, Dolara P. Eu.Gene Analyzer a tool for integrating gene expression data with pathway databases.Bioinformatics. 2007 Jun 28; [Epub ahead of print]Molyneaux BJ*, Arlotta P*, Menezes JR, Macklis JD. Neuronal subtype specification in thecerebral cortex. Nat Rev Neurosci. 2007 Jun;8(6):427-437.Nissim S, Allard P, Bandyopadhyay A, Harfe BD, Tabin CJ. Characterization of a novel ectodermalsignaling center regulating Tbx2 and Shh in the vertebrate limb. Dev Biol. 2007 Apr1;304(1):9-21. Epub 2006 Dec 9.Sarpeshkar R, Wattanapanitch W, Rapoport BI, Arfin S, Baker M, Mandal S, Fee M,Musallam S, Andersen R. Low-Power Circuits for Brain-Machine Interfaces. Proceedings ofthe International Symposium on Circuits and Systems (May 2007).Reddy SK, Rape M, Margansky WA, Kirschner, MW. Ubiquitination by the anaphase-promotingcomplex drives spindle checkpoint inactivation. Nature 2007 Apr 19; 446 (7138):868-9.Newhouse JP, Seiguer E, Frank RG.: Was Part D a Giveaway to the Pharmaceutical Industry?Inquiry Vol. 44, No. 1, pp. 15–25.Farris W, Schutz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM,Qiu WQ, Holtzman DM, Selkoe DJ. Loss of Neprilysin Function Promotes Amyloid PlaqueFormation and Causes Cerebral Amyloid Angiopathy. Am J Pathol. 2007 May 18; [Epubahead of print]Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL. Naturaloligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulatingan NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci. 2007 Mar14;27(11):2866-75.Li W*, Schulman S*, Boyd D, Erlandson K, Beckwith J, Rapoport TA. The Plug Domain ofthe SecY Protein Stabilizes the Closed State of the Translocation Channel and Maintains aMembrane Seal. Mol Cell. 2007 May 25;26(4):511-21.Saparov SM, Erlandson K, Cannon K, Schaletzky J, Schulman S, Rapoport TA, Pohl P.Determining the Conductance of the SecY Protein Translocation Channel for SmallMolecules. Mol Cell. 2007 May 25;26(4):501-9.Taniguchi CM, Aleman JO, Ueki K, Luo J, Asano T, Kaneto H, Stephanopoulos G, CantleyLC, Kahn CR. The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance. Moll Cell Biol. 2007 Apr;27(8):2830-40.Epub 2007 Feb 5.Thierman JS, Clement GT, Kalish LA, O’Kane PL, Frauscher F, Paltiel HJ. Automated sonographicevaluation of testicular perfusion. Phys Med Biol. 2006 Jul 21;51(14):3419-32. Epub2006 Jun 26.Tothova Z, Mercher T. FoxO: stress or eternal life. Med Sci (Paris). 2007 May;23(5):466-467.FrenchKlose R, Yan Q, Tothova Z, Yamane K, Erdjument-Bromage H, Tempst P, Gilliland DG,Zhang Y, Kaelin WG. The retinoblastoma binding protein RBP2 is an H3K4 demethylase.Cell. 2007 Mar 9;128(5):889-900. Epub 2007 Feb 22.Wieland SC, Brownstein JS, Berger B, Mandl KD. Density-equalizing Euclidean minimumspanning trees for the detection of all disease cluster shapes. Proc Natl Acad Sci U S A. 2007May 29;104(22):9404-9. Epub 2007 May 22.HARVARD MD-PHD PROGRAM newsletter11

For the RecordClass of 2007 Internship/Residency and Postgraduate AppointmentsAndrew James Aguirre, Internal Medicine,Massachusetts General Hospital, Boston, MA.Jakob Begun, Internal Medicine, Brigham andWomen’s Hospital, Boston, MA.Irene Ann Chen, Bauer Fellow, Harvard Faculty ofArts & Sciences, Cambridge, MA.David M. Cochran, Adult and Child PsychiatryResidency, University of Massachusetts, MemorialMedical Center, Worcester, MA.Sophie Christine Currier, Pathology, MassachusettsGeneral Hospital, Boston, MA.Phillip A. Erwin, Internal Medicine, MassachusettsGeneral Hospital, Boston, MA.Jean-Marc Gauguet, Radiology, Beth Israel DeaconessMedical Center, Boston, MA.Robert Stewart Griffin, Anesthesiology,Massachusetts General Hospital, Boston, MA.Ashutosh Prabhakar Jadhav, Neurology,Massachusetts General Hospital, Boston, MA.David Hyun Jung, Otolaryngology, Mass Eye and EarInfirmary, Boston, MA.Rita Khodosh, Dermatology, Stanford UniversityPrograms, Stanford, CA.,Andrew David Levin, Genzyme Corporation,Cambridge, MA.Bradley John Molyneaux, Neurology, MassachusettsGeneral Hospital, Boston, MA.Sahar Nissim, Internal Medicine, Brigham andWomen’s Hospital, Boston, MA.Michael Abram Ohliger, Radiology, UCSF, SanFrancisco, CA.James Rhee, Anesthesiology, Massachusetts GeneralHospital, Boston, MA.Douglas A. Rubinson, Internal Medicine, Brighamand Women’s Hospital, Boston, MA.Safa Sadeghpour, Associate, McKinsey & Company,Florham Park, NJ.Erica Seiguer, Internal Medicine, MassachusettsGeneral Hospital, Boston, MA.Jay Ashok Shendure, Assistant Professor of GenomeSciences, University of Washington, Seattle, WA.Benjamin Daniel Sommers, InternalMedicine/Primary Care, Brigham and Women’sHospital, Boston, MA.David Yoshio Takeda, Internal Medicine, Brighamand Women’s Hospital, Boston, MA.Jonathan Sidney Thierman, Emergency Medicine,Johns Hopkins Hospital, Baltimore, MD.Vesselin T. Tomov, Internal Medicine, Hospital ofUniversity of Pennsylvania, Philadelphia, PA.Griffin M. Weber, Chief Technology Officer, HarvardMedical School; Director of the BiomedicalInformatics Core and Instructor in Medicine, BethIsrael Deaconess Medical Center, Boston, MA.Ernest Nanjung Yeh, Radiology/Scholar Track, BethIsrael Deaconess Medical Center, Boston, MA.Lisa Maher Zakhary, Psychiatry, MassachusettsGeneral Hospital, Boston, MA.Save the Date25th Annual Student/Faculty RetreatOctober 12-14, 2007Waterville Valley Conference CenterWaterville Valley, New HampshireWeekend Highlight:Eva Neer Memorial Lecture presentedby Dr. Nancy C. Andrews, George MinotProfessor of Pediatrics and Dean forBasic Sciences and Graduate Educationat HMS – Title: “Serendipity”The retreat includes research presentationsby senior students, student/facultyposter session, panel discussions,recreational hikes, music and dancing.visit our website at www.hms.harvard.edu/md_phdHARVARD MEDICAL SCHOOLMD-PhDPROGRAMnewsletterTOSTESON MEDICAL EDUCATION CENTER260 LONGWOOD AVENUE,ROOM 168BOSTON,MASSACHUSETTS 02115-5720mdphd@hms.harvard.eduwww.hms.harvard.edu/md_phdTEL 617-432-0991FAX 617-432-2791PresortedFirst-Class MailU.S. Postage PAIDPermit 250Mailed from 01842