Formulation and evaluation of Norfloxacin Dispersible tablets using ...

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A N Merekar et al Journal of Chemical and Pharmaceutical Research, 2009, 1(1): 336-341______________________________________________________________________________Figure1: Comparison of cumulative % drug release of formulated and marketedNorfloxacin dispersible tabletDrug Release PLOT of NorfloxacinContaining Ispaghula huskD r ug R e l e a se P l ot of N or f l ox a c i n C ont a i ni ngC a ssi a t or a100Cumulative % drugrelease1005000 2 4 6Time in minN IH(5%)N IH (10%)N IH(15%)N MKTD8060402000 2 4 6T i me i n mi nN CT (5%)N CT (10%)N CT (15%)N MKTDFigure1 (a) Cumulative %Drug Release ofNorfloxacin Tablet Containing IspaghulaHusk as DisintegrantFigure1 (b) Cumulative %Drug Release ofNorfloxacin Tablet Containing Cassia Toraas DisintegrantDrug Release Plot of Norfloxacin Containig Cassiatora(defatted)Drug Release Plot of NorfloxacinContaining Cassia nodosa90Cuulative % drug release807060504030201000 2 4 6Time in minN CTD (5%)N CTD (10%)N CTD (15%)N MKTD1008060402000 5 10Ti me i n m i nN CN (5%)N CN (10%)N CN (15%)N MKTDFigure1(c) Cumulative %Drug Release ofNorfloxacin Tablet Containing Cassia toraDisintegrantFigure1 (d) Cumulative %Drug Release ofNorfloxacin Tablet Containing Cassia nodosa asas DisintegrantC) Dissolution studies:Dissolution studies were performed using a dissolution test apparatus USP XXII. (Basketassembly) at 100 rpm using 750 ml of acetate buffer(pH- 4.0) and temperature was maintained at37+ 0.5 0 through out the study. Ten millimeter of the sample was withdrawn at a regular intervaland replaced with an equal volume of phosphate buffer. Samples were filtered and drug contentwas estimated by UV spectrophotometer at 278nm. Dissolution data shown in table 3.Available online at www.jocpr.com 339
A N Merekar et al Journal of Chemical and Pharmaceutical Research, 2009, 1(1): 336-341______________________________________________________________________________Table 3: In Vitro Study of Selected Formulated and Marketed dispersible Tablet ofNorfloxacinFormulationCodeN IH 1NCT 1NCTD 1NCN 1N MKTDTime(Min)1234512345123451234512345DissolutionEfficiency(%)Uniformity ofDispersion88.68 PASSES78.67 PASSES70.09 PASSES71.52 PASSES82.96 PASSES(Where N IH Is DT Norfloxacin With Ispaghula Husk, NCT Is DT Norfloxacin With Cassia Tora, NCTD Is DTNorfloxacin With Cassia Tora(Defatted), NCN Is DT Norfloxacin With Cassia Nodosa, N MKTD Is Marketed DTNorfloxacin ,1 Indicates 5%Concentration Respectively)Result and DiscussionThe % drug content was found to be between 99.00% to 100.00%, which was within acceptablelimits. The hardness was found to be 2.5Kg/ cm 2 to 4.0 Kg/ cm 2 , Percent friability was less than1% in the entire formulation and values obtained lies between 0.28 –0.52. All the formulationsAvailable online at www.jocpr.com 340
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