Formulation and evaluation of Norfloxacin Dispersible tablets using ...
Formulation and evaluation of Norfloxacin Dispersible tablets using ...
Formulation and evaluation of Norfloxacin Dispersible tablets using ...
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A N Merekar et al Journal <strong>of</strong> Chemical <strong>and</strong> Pharmaceutical Research, 2009, 1(1): 336-341______________________________________________________________________________B) Evaluation <strong>of</strong> Formulated Tablet:The various formulations were evaluated for hardness, weight variation, friability, disintegrationtime, Invitro disintegration time, wetting time, uniformity <strong>of</strong> dispersion, drug content/contentuniformity, <strong>and</strong> dissolution study.Disintegration time was determined <strong>using</strong> Thermonic Tablet Disintegration apparatus USP <strong>using</strong>distilled water as a disintegration medium. Each formulation was tested for uniform dispersion asper <strong>of</strong>ficial st<strong>and</strong>ards. After disintegration beaker was shaken <strong>and</strong> this fluid was passed throughthe sieve no.22. Hardness <strong>of</strong> the tablet was tested Pfizer hardness tester <strong>and</strong> friability by RocheFriabilator. Drug content was determined by <strong>using</strong> UV spectrometer (Shimadzu) at 263 nm. The<strong>evaluation</strong> parameters shown in Table No 2.Table2: Evaluations date <strong>of</strong> formulated dispersible tablet <strong>of</strong> <strong>Norfloxacin</strong><strong>Formulation</strong>HardnessKg/cm 2(n=3)Friability(%)(n=3)Wt.Variation(%)(n=3)Disinte.Time(Sec)(n=3)WettingTime(Sec)(n=3)Drugcontent±SD(n=3)N IH 1 3.00 0.28 0.22 31 145 99.5±0.028N IH 2 3.00 0.40 0.25 34 153 98.5±0.022N IH 3 3.16 0.48 0.28 46 165 99.0±0.022NCT1 2.66 0.40 0.34 65 190 99.3±0.027NCT2 3.3 0.48 0.36 73 200 99.0±0.037NCT3 2.83 0.48 0.40 80 223 99.0±0.015NCTD1 3.33 0.40 0.41 73 220 99.5±0.025NCTD2 3.16 0.48 0.48 87 246 99.0±0.034NCTD3 2.66 0.60 0.50 96 264 99.0±0.034NCN1 3.33 0.40 0.24 50 170 99.5±0.021NCN2 3.26 0.52 0.31 58 183 99.4±0.021NCN3 3.50 0.52 0.39 65 215 99.0±0.025N3.33 0.34 0.28 61 160 99.5±0.028MKTD(Where N IH Is DT <strong>Norfloxacin</strong> With Ispaghula Husk NCT Is DT <strong>Norfloxacin</strong> With Cassia Tora, NCTD Is DT<strong>Norfloxacin</strong> With Cassia Tora(Defatted), NCN Is DT <strong>Norfloxacin</strong> With Cassia Nodosa, N MKTD Is Marketed DT<strong>Norfloxacin</strong> 1,2,3 Indicates 5%,10%,15% Concentration)Comparison <strong>of</strong> Cumulative % Drug Release <strong>of</strong> Formulated <strong>and</strong> Marketed Isoniazid <strong>Dispersible</strong>Tablet was shown in figure 1.Available online at www.jocpr.com 338
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