molecular function & imaging symposium: heart failure - University of ...

MOLECULAR FUNCTION & IMAGING SYMPOSIUM:HEART FAILUREJune 18–19 th 2010Westin Hotel, Ottawa11:15-11:30 The nutritional regulation of enzymatic sources ofNADPH in skeletal muscle mitochondria: novel roles forglucose and glucose-6-phosphate dehydrogenase11:30-11:45 A ligand-enhanced collagen matrix for neovascularizationand myogenesis of ischemic tissueRyan MaillouxPostdoctoral FellowMitochondrial Bioenergetics LabUniversity of OttawaTanja SofrenovicMSc StudentDivision of Cardiac SurgeryUniversity of Ottawa Heart Institute11:45-12:30 LUNCH & POSTER BROWSINGFoyer & Governor General IIISESSION II – CLINICAL IMAGING OF HEART FAILUREKEYNOTE LECTURE II12:30-1:15Clinical Imaging in Heart FailureGovernor General IIIDr Marcelo Di CarliChief of Nuclear MedicineBrigham & Women’s HospitalHarvard Medical SchoolORAL ABSTRACT SESSION II (1:30-2:45)Moderator:Co-Moderator:Dr Marcelo Di CarliDr Eric Larose (Lawson Health Research Institute)Ms Jennifer Renaud (Imaging Physics, UOHI)1:15-1:30 Title TBD Myra CockerGraduate StudentStephenson CMR CentreUniversity of Calgary1:30-1:45 Impaired myocardial flow reserve using rubidium-82 PETpredicts outcomes in patients with suspected myocardialischemia1:45-2:00 Magnetic resonance characterization of trabeculated vs.non-trabeculated myocardium in healthy adults: a first stepto defining non-compacted cardiomyopathyMaria Cecilia ZiadiClinical FellowCardiac ImagingUniversity of Ottawa Heart InstituteHelena Tizon-MarcosMRI FellowCentre de recherche de l’Instituteuniversitaire de cardiologie et depneumologie de QuebecUniversité LavalSymposium Programii

MOLECULAR FUNCTION & IMAGING SYMPOSIUM:HEART FAILUREJune 18–19 th 2010Westin Hotel, Ottawa2:00-2:15 Inverse relationship between cardiac oxidative metabolismand vagal modulation of heart rate variability in heartfailure patients with and without obstructive sleep apnea2:15-2:30 The use of FDG PET imaging in the diagnosis of cardiacsarcoid: a systemic review including the UOHI experience2:30-2:45 Rest and stress dosimetry for rubidium-82 using neweffective dose estimates based on dynamic PET/CTimaging in humansPetsy Pui-Sze SoMedical StudentCardiac ImagingUniversity of Ottawa Heart InstituteGeorge YoussefClinical FellowCardiac ImagingUniversity of Ottawa Heart InstituteChad HunterMSc StudentImaging PhysicsUniversity of Ottawa Heart Institute2:45-3:00 COFFEE BREAKFoyerIMAGE-HF / MFI JOINT WORKSHOP II3:00-4:00 From the Crossroads: Starting a Scientific CareerProgression of a Basic Research CareerProgression of a Clinical Research CareerDr Jason DyckUniversity of AlbertaDr Darryl DavisUniversity of Ottawa Heart InstituteDr Mary-Ellen Harper *University of Ottawa4:00 END OF DAY 1IMAGE-HF STEERING COMMITTEE MEETING4:00-5:00 IMAGE-HF STEERING COMMITTEE MEETINGNewfoundland Room(By invitation)Symposium Programiii

MOLECULAR FUNCTION & IMAGING SYMPOSIUM:HEART FAILUREJune 18–19 th 2010Westin Hotel, Ottawa7:30-8:30 REGISTRATION & BREAKFASTFoyer to Confederation IISaturday, June 19 th 2010IMAGE-HF / MFI JOINT WORKSHOP III8:30-9:45 Novel Heart Failure Therapy: Expanding the BordersGene Therapy in Heart FailureCardiac Resynchronization & Device TherapyCell-Based Therapeutic ApproachesConfederation IIDr Alexandre StewartUniversity of Ottawa Heart InstituteDr David BirnieUniversity of Ottawa Heart InstituteDr Duncan Stewart *Ottawa Hospital Research Institute9:45-10:00 COFFEE BREAKFoyerSESSION III – PRECLINICAL IMAGING IN HEART FAILURE AKEYNOTE LECTURE III10:00-10:45Preclinical Imaging in Heart FailureConfederation IIDr Juhani KnuutiDirector, Turku PET CentreUniversity of TurkuORAL ABSTRACT SESSION III (10:45-11:00)Moderator:Co-Moderator:Dr Juhani KnuutiDr Duncan Stewart (Ottawa Hospital Research Institute)Mr Tyler Dumouchel (PhD Candidate, Imaging Physics)10:45-11:00 Accuracy of CMR methods in assessment of leftventricular and atrial volumes and myocardial mass:comparison of SA and long axis techniques with ex-vivomodel11:00-11:15 In vitro cytotoxicity evaluation of 111-indium on canineendothelial progenitor cells for in vivo transplanted cellviability imagingHelene ChildsGraduate StudentStephenson CMR CentreUniversity of CalgaryKimberley BlackwoodGraduate StudentMedical Biophysics & MedicalImagingUniversity of Western OntarioSymposium Programiv

MOLECULAR FUNCTION & IMAGING SYMPOSIUM:HEART FAILUREJune 18–19 th 2010Westin Hotel, Ottawa11:15-11:30 Animal model of coronary artery ligation and reperfusionfor cardiac PET imaging11:30-11:45 Increased cardiac phosphodiesterase-4 levels are observedat 8-10 weeks post-myocardial infarction with(R)-[ 11 C]rolipram PET11:45-12:00 A collagen matrix for endothelial progenitor cell therapyimproves cardiac function in a mouse myocardialinfarction modelKumiko MackaseyMSc StudentPET BioTesting LaboratoryUniversity of Ottawa Heart InstituteMiran KenkPhD CandidatePET BioTesting LaboratoryUniversity of Ottawa Heart InstituteAli AhmadiPhD CandidateDivision of Cardiac SurgeryUniversity of Ottawa Heart Institute12:00-12:30 LUNCH & POSTER BROWSINGFoyer & Confederation IIFORMAL POSTER SESSION12:30-2:00 POSTER PRESENTATIONSFoyer & Confederation IIPresenters at postersIMAGE-HF / MFI JOINT WORKSHOP IV2:00-3:15 Hitting the Bullseye: Targets for Tracer-BasedMolecular ImagingSPECT Targets for Heart FailurePET Targets for Heart FailureMRI Targets for Heart FailureConfederation IIDr Glenn WellsUniversity of Ottawa Heart InstituteDr Juhani KnuutiTurku PET CentreDr Alexander DickSunnybrook Hospital, U TorontoDr Terry Ruddy *University of Ottawa Heart Institute3:15-3:30 COFFEE BREAKFoyerSymposium Programv

MOLECULAR FUNCTION & IMAGING SYMPOSIUM:HEART FAILUREJune 18–19 th 2010Westin Hotel, OttawaSESSION IV – CLINICAL AND PRECLINICAL IMAGING IN HEART FAILURE BORAL ABSTRACT SESSION I (3:30-4:30)Moderator:Co-Moderator:Dr Juhani KnuutiDr Terry Ruddy (UOHI)Dr Vikas Tandon (Clinical Fellow, UOHI)3:30-3:45 Title TBD Trainee TBDStephenson CMR CentreUniversity of Calgary3:45-4:00 Right ventricle glucose metabolism reflects the severity ofpressure overload in patients with pulmonary arterialhypertension4:00-4:15 Test-retest reproducibility and reliability of FDG PETimaging in mice and rats using different kinetic modelingapproaches4:15-4:30 Iodine-123/125 labeled annexin V as a potential SPECTtracer for cardiac apoptosis4:30-4:45 Inverse correlation of [ 11 C]meta-hydroxyephedrine cardiacretention measures to norepinephrine concentration in ratsPeter MitoffResidentDivision of CardiologyUniversity of Ottawa Heart InstituteStephanie ThornPhD CandidatePET BioTesting LaboratoryUniversity of Ottawa Heart InstituteDaniel DuanCanadian Molecular Imaging Centreof ExcellenceMDS NordionUniversity of Ottawa Heart InstituteJames ThackerayPhD CandidatePET BioTesting LaboratoryUniversity of Ottawa Heart InstituteCLOSE OF SESSIONS4:45-5:00Closing RemarksConfederation IIDr Terry RuddyChief of CardiologyUniversity of Ottawa Heart Institute5:00 END OF DAY 2Symposium Programvi

SYMPOSIUM LOCATIONWESTIN HOTELFloor and Room Locations11 Colonel By DriveOttawa, ON K1N 9H4613-560-7000Symposium Programvii

EVENING EVENTWESTIN HOTELFloor and Room Locations6:00 to 1:00 am11 Colonel By DriveOttawa, ONEvent Details:6:00-7:30Cocktail and Canapé Reception7:30 Banquet Dinner8:30 MFI Award Presentations9:00 Music and Dancing1:00 CloseSymposium Programviii