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Pathogen survival in protozoa• Enteric pathogens may survive & replicate inprotozoa, mainly Amoeba• Pathogens within protozoa may show enhancedvirulence• Increased virulence is related to the presence ofthe SGI1 resistance integron• This may be a significant pathogen survivalmechanism in water, the rumen & in soil

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Virulence enhancement in rumen protozoa% Hep-2 cell invasionSalmonella strainsRasmussen et al., 2005

Pathogen survival in protozoa• Enteric pathogens may survive & replicate inprotozoa, mainly Amoeba• Pathogens within protozoa may show enhancedvirulence• Increased virulence is related to the presence ofthe SGI1 resistance integron• This may be a significant pathogen survivalmechanism in water, the rumen & in soil

Page 4 and 5: Bovine GI tractpH (6.0-7.0)pH (2.0-
Page 7: Pathogen survival in the GI tract
Page 11 and 12: Survival in the abomasum• Cells e
Page 13 and 14: Acid adaptation in the live animal
Page 15 and 16: Stresses which occur in foods & in
Page 17 and 18: Leyer and Johnson, 1992The influenc
Page 19: Pathogen replication in Acanthamoeb
Page 23 and 24: E. coli O157:H7 producing vesicles