From Protein Structure to Function with Bioinformatics.pdf

20 J. Lee et al.viewpoint of structure prediction is quite limited. One reason is the prohibitive computingdemand for a normal size protein. On the other hand, knowledge-based (or hybridknowledge- and physics-based) approaches appear to be progressing rapidly, producingmany examples of successful low-to-medium accuracy models often with correct topologyfor proteins of up to 100 residues. Although very rare, successful higher resolutionmodels (