Health and Nutrition Product Guide - Anshul Life Sciences

www.ispcorp.comHealth and NutritionProduct GuidePerformance Enhancing Products

Introduction..................................................................................... 3Table of ContentsApplication Selection Guide.................................................... 5Binders and Solubilizers.Plasdone® K Povidone............................................................................ 6.Plasdone® C Povidone............................................................................. 6.Plasdone® S-630 Copovidone............................................................... 7.CAVAMAX® Native Cyclodextrins......................................................... 8.CAVITRON® and CAVASOL® Derivative Cyclodextrins.................... 8.Pharmasolve® Drug Solubilizer............................................................ 9.2-Pyrol® Drug Solubilizer....................................................................... 9Disintegrants.Polyplasdone® Crospovidone..............................................................10Film Coating Systems.Advantia Prime Coating Systems.....................................................11.Advantia Performance Coating Systems........................................12solvents .THF Tetrahydrofuran Solvent.............................................................13Active Ingredients.Ferronyl® Carbonyl Iron Supplement................................................14.Polyplasdone® INF-10 Crospovidone.................................................14.PVP-Iodine Antiseptic..........................................................................15 .Allantoin Skin Protectant....................................................................15Topical Excipients.Ceraphyl® Emollients ...........................................................................16.Cerasynt® Emulsifiers............................................................................16.Prolipid® Lamellar Gel System............................................................17.Preservatives..........................................................................................17Biomedical Polymers.Gantrez® Copolymers............................................................................18ISP Pharma Techonologies......................................................19.CAVAMAX® and CAVASOL® are registered trademarks ofWacker-Chemie AG.Health and Nutrition Product Guide

For over 50 years, ISP has been a leading supplier ofhigh quality products used to enhance performance inhealth and nutrition applications. Today, ISP producesmore than 30 products for use in oral solids, liquids andsemi-solids; parenterals; topicals and ophthalmic dosageforms. This product guide can help you locate a productto meet your application needs.Plasdone® BindersISP offers a comprehensive range of binders for wetgranulation, dry granulation or direct compressiontablet manufacturing processes. Our Plasdone® Kpolymers are the premier high performance binders forwet granulation. Plasdone® S-630 polymer is a superior,high-performance dry binder in both direct compressionand dry granulation.CAVAMAX®, CAVitron® and CAvasol®CyclodextrinsAs a result of their molecular structure andshape, cyclodextrins have a unique ability toact as molecular containers by entrappingguest molecules in their internal cavity. Theresulting inclusion complexes are used ina number of pharmaceutical applicationsincluding: increasing water solubility of poorlysoluble drugs to improve bioavailability; tastemasking bitter actives for use in chewable; andorally disintegrating tablet applications, and;stabilizing drug actives to inhibit light, thermaland oxidative degradation. ISP offers thebroadest range of cyclodextrin products to helpachieve specific formulation objectives.IntroductionPolyPlasdone® SuperDisintegrantsISP provides Polyplasdone® Crospovidone for rapiddisintegration and dissolution of oral solid dosageforms. A synthetic, cross-linked polymer, Polyplasdone®Crospovidone is available in two particle sizes toprovide formulation flexibility for small and largetablets or intragranular and extragranular applications.With its small particle size and rapid disintegration,Polyplasdone® XL-10 Crospovidone is preferred for orallydisintegrating tablet (ODT) formulations.Advantia Coating SystemsAdvantia Prime and Performance Coating Systemsare pre-blended, ready-to-use powders that are readilydispersed in water and applied to the substrate. ISP hasdeveloped Advantia Prime and Performance CoatingSystems utilizing a scientific approach for characterizingthe nature of the relationships between componentsand their use levels in film coating formulations forimmediate-release and enteric-release dosage forms.Each system is formulated and selected to provide theoptimum performance.Topical ExcipientsWith a wealth of experience in products forskin care, ISP offers a range of emollientsand conditioners, to improve the aestheticsof topical creams and lotions. The Ceraphyl®product line contains a series of long chainfatty esters that provide a range of aestheticproperties. ISP offers a range of high qualityfatty esters, derived from vegetable sources,for use as primary and auxiliary oil-inwateremulsifiers for a variety of topicalpharmaceutical formulations.ISP’s preservative products deliver broadspectrum activity and compatibility protectingtopical formulations from antimicrobialcontamination.Health and Nutrition Product Guide

Application Function ProductsOral SolidsOral liquidsandsemi-solidsParenteralsOphthalmicTopicalsBiomedicalPolymersActive StabilizationDirect Compression Binder Aid Plasdone® S-630DisintegrantEncapsulation/TastemaskingCAVAMAX®, CAVITRON® and CAVASOL® CyclodextrinsPolyplasdone® XL and XL-10CAVAMAX® CyclodextrinsFilm Coating Additives Plasdone® S-630Film Coating Systems (Aesthetic and Enteric Release)Advantia Coating SystemsGranulation Binder - Dry Plasdone® S-630Granulation Binder - WetIron SupplementSolubility EnhancementIron SupplementSolubility EnhancementSuspension AgentsThickening AgentsCrystal InhibitionSolubility EnhancementSolubilty EnhancementCrystal InhibitionViscosity ModifierLubricityAntisepticsEmollients and ConditionersPlasdone® K-25, K-29/32, K-90 and K-90DFerronyl® IronPlasdone® K, Plasdone® S-630, CAVAMAX®, CAVITRON® andCAVASOL® Cyclodextrins, Polyplasdone® XL and XL-10Ferronyl® IronPlasdone® K, Plasdone® S-630, CAVAMAX® and CAVASOL®CyclodextrinsPolyplasdone® INF-10Plasdone® CPlasdone® C, Pharmasolve®, 2-Pyrol®Plasdone® C, Pharmasolve®, 2-Pyrol®, CAVITRON CyclodextrinsPlasdone® CPVP-IodineCeraphyl®Emulsifiers Cerasynt® SD and 945Film Formers Gantrez®, Plasdone® S-630Lamellar Gels Systems Prolipid® 141PreservativesSkin ProtectionThickening AgentsBioadhesivesGermall 115 and II, Germall Plus and Liquid Germall Plus,Germaben II and II-E, LiquaPar Oil, PE and OptimaAllantoin USPPlasdone® KGantrez®, Plasdone® KFilm Formers Gantrez®, Plasdone® S-630Lubricious CoatingsPlasdone® CPore Formation Plasdone® K-90Wound CareGantrez®, PVP-IodineApplication Selection GuideHealth and Nutrition Product Guide

Oral Solids · Oral Liquids and Semi Solids · Topicals · Medical DevicesPlasdone® S-630 PolymerCopovidone USP/NF, Ph. Eur., JPEProductK-ValueWeight AverageMolecular WeightPlasdone® S-630 25-31 24,000-30,000Description60:40 copolymer of vinylpyrrolidone and .vinyl acetate (PVP/VA)AppearanceWhite to creamy white, free-flowing powderChemistryPropertiesCH 2CHNnOCH 2CH• Soluble in water and most pharmaceutically acceptable solvents• Lower glass transition temperature (Tg) than vinylpyrrolidonehomopolymers (106Plasdone o C comparedS-630to ~165 o C for Plasdone K-29/32CAS# 25086-89-9PVP)• Forms hard, glossy, transparent, air-permeable, water .removable films• More substantive and better film former than vinylpyrrolidonehomopolymers due to increased hydrophobicity and lower Tg• Lower hydroscopicity than PVP .mO CH 3COBinders and SolubilizersApplications and Benefits• Serves as tablet binder in wet and dry granulation and directcompression tablet processes• Improves compactability of other binders and fillers in directcompression tablet process• Improves solubility and enhances bioavailability of drug actives• Gives excellent performance as binder in moisture sensitiveformulations• Enhances appearance and color stability of tablet film coatings• Increases productivity of film coating process by increasingsuspension solids• Improves adhesion of tablet coatings to hydrophobic cores• Possesses excellent film forming properties and high .substantivity to skinHealth and Nutrition Product Guide

Oral Solids · Oral Liquids and Semi-SolidsCAVAMAX ® CyclodextrinsUSP/NF, Ph. Eur., JP selected productsOral Solids · Oral Liquids and Semi-Solids · ParenteralsCAVITRON ® and CAVASOL ® CyclodextrinsUSP/NF, Ph. Eur., selected productsBinders and SolubilizersProductsCyclodextrinTypeNumber of Glucose UnitsCAVAMAX® W6 Pharma a 6CAVAMAX® W7 Pharma ß 7CAVAMAX® W8 Pharma g 8DescriptionBucket-shaped, cyclic, oligo-saccharides produced .from starchAppearanceWhite, free-flowing powderChemistryHydrophobic CavityProductsCAVITRON® W7 HP5PharmaCAVITRON® W7 HP7PharmaCAVASOL® W7 HP PharmaCAVASOL® W8 HP PharmaCyclodextrin TypeHydroxypropyl-bcyclodextrinHydroxypropyl-bcyclodextrinHydroxypropyl-bcyclodextrinHydroxypropyl-gcyclodextrinTypical Degree ofSubstitution4.1-5.16.0-8.04.1-5.13.5-4.9The CAVITRON grades of hydroxypropyl-b-cyclodextrin are manufactured to control endotoxin levels.DescriptionHydroxypropyl substituted, bucket-shaped, cyclic, .oligo-saccharides produced from starchAppearanceWhite to off-white powderChemistryHydrophilic ExteriorProperties• Water soluble• Very stable at alkaline pH; stable in acidic solutions above pH 3• Hydrophobic interior cavity; hydrophilic exterior• Cavity size depends on number of glucose units in .cyclodextrin ring• Can form complexes with drug activesApplications and Benefits• Enhances bioavailability by increasing water solubility of .poorly-soluble drug actives• Improves the light, thermal and oxidative stability of drug activesthrough formation of inclusion complexes• Reduces dermal, gastrointestinal or ocular irritation throughcomplex formation• Masks unpleasant tastes and odors of drug actives to improvepatient compliance• Prevents drug-drug and drug additive interactions• Simplifies product handling by reducing volatility of actives orconverting liquids to powdersProperties• Water soluble• Stable in base and weak organic acids, but are hydrolyzed .by strong acids• Hydrophobic interior cavity; hydrophilic exterior• Can form complexes with drug activesApplications and Benefits• Enhances bioavailability by increasing water solubility of .poorly-soluble drug actives• Improves the light, thermal and oxidative stability of drug activesthrough formation of inclusion complexes• Reduces dermal, gastrointestinal or ocular irritation throughcomplex formation• Prevents drug-drug and drug additive interactions• Simplifies product handling by reducing volatility of actives orconverting liquids to powdersHealth and Nutrition Product Guide

Oral SolidsAdvantia Prime Coating SystemsAdvantia Prime Coating Systems are pre-blended, ready-to-use powders that are readily dispersed in water and applied to immediaterelease dosage forms. Based on existing pharmaceutically-acceptable polymers, for example hydroxypropylmethyl cellulose (HPMC),Advantia Prime Coating Systems are available pigmented or unpigmented. The products listed below are standard concept samples thatcontain ingredients acceptable in North America, European Union and Japan for use on pharmaceutical products. The products listed areonly a sampling of the formulations available.Product Name Color Suggested Suspension Solids (%) Suggested Weight Gain (%)Advantia Prime 199900BA01 Clear 10-12% 1%Advantia Prime 190100BA01 White 12-15% 3%Advantia Prime 144900BA01 Yellow 12-15% 3-4%Advantia Prime 171900BA01 Pink 12-15% 3-4%Film Coating SystemsPharmaceuticals Product Guide 11

Oral SolidsAdvantia Performance Coating SystemsFilm Coating SystemsAdvantia Performance Coating Systems are pre-blended, ready-to-use powders based on methacrylic acid ethyl acrylate copolymer .for delayed release (enteric release) film coating of pharmaceutical oral solid dosage forms, including:• Tablets• Multiparticulates• Two-piece gelatin capsules• SoftgelsAvailable pigmented or unpigmented, Advantia Performance Coating Systems are easy-to-use powders that can be readily dispersed .in water and applied.With an Advantia Performance Coating Systems, suspension preparation is simple. The more traditional procedure for preparing .enteric-coating suspensions often requires three steps. In the traditional process, the first step is to homogenize the plasticizer, .detackifier and optionally, an antifoam agent in water to form a suspension. After a suitable mixing time, this suspension is then added,with mixing, to an acrylic polymer dispersion. This combined suspension is passed through a sieve. For a colored enteric-coatingformulation, a colorant must also be added using an additional processing step.With Advantia Performance Coating Systems, the Advantia Performance powder is added to water (stirred in a suitable mixing tank .to create a vortex) and mixed. There are fewer processing steps involved, and fewer ingredients to inventory and submit to quality .control testing compared to a traditional system, thus saving time and money.Advantia Performance 190024HA49Advantia Performance 190024HA49, a white coating formulation, has been selected as our standard concept sample as it provides .an overall excellent combination of properties for coating tablets. It is recommended to use Advantia Performance Coating Systems .at 20% solids in water. The maximum solids level will depend on the particular spray gun, pump and coating equipment used.In cases where a different coating system is required and acheive desired performance, ISP scientists utilize the design of experiments(D.o.E.) software in combination with responses generated from the design of experiments, to produce a coating formulation more suitable .for any given application.When a colored tablet is required, a colored Advantia Performance coating can be formulated to meet individual color needs, limited onlyby specific color regulations. ISP maintains strict color control to ensure lot-to-lot consistency.12 Health and Nutrition Product Guide

THF SolventDescriptionTetrahydrofuranAppearanceLiquidChemistrySolventsProperties• Purity: 99.9%• Boiling Point: 66 o C• Melting Point: -108.5 o C• Viscosity (25 o C): 0.47 cP• Flash Point (Tag Closed Cup): -14.4 o C• Completely miscible with water, most organic solvents, includingalcohols, diethylether, esters, ketones, aliphatic aromatic andchlorinated hydrocarbons• Highly volatile, flammable liquid• Noncorrosive to ordinary metals used for storage and processingequipment• Sterically unhindered oxygen with two unshared pairs of electronswhich favor formation of coordination complexesApplications and Benefits• Extraction solvent. In combination with water, effectivelyextracts physiologically active alkaloids such as caffeine• Excellent medium for chemical reactions involving Gringard andorganometalic reagents• Steroid hormone production for use in birth control pills• Offers new routes for many synthesesHealth and Nutrition Product Guide 13

Oral Solids · Oral LiquidsFerronyl® Iron SupplementDescriptionUltra-fine, elemental iron with greater than 98% pure iron;Carbonyl iron powderOral Solids · Oral LiquidsPolyplasdone® INF-10Crospovidone USP/NF, Ph. Eur., JPEProductsTypical Average Particle Size (µm)Polyplasdone® INF-10 10Active IngredientsAppearanceGray powderChemistryProperties• Lower acute toxicity compared to ferrous saltsDescriptionNon-ionic, crosslinked polyvinylpyrrolidone (PVP), PVPPAppearanceWhite, free-flowing powderChemistry• Excellent bioavailability due to fine, spherical particlemorphology• High iron dose per unit weight compared to ferrous salts• Very stable• Easy to formulateApplications and Benefits• Provides source high in bioavailable iron for multivitamins, ironsupplements and chewable children’s multivitamins• Fortifies food with iron, an essential nutrient for humans andanimalsProperties• Insoluble in water and all other common solvents• Large specific surface area• Non-ionicApplications and Benefits• Approved for use in some countries as an active to treatgastrointestinal disorders and as an anti-diarrheal agent inhuman and veterinary applications. ** Subject to local regulatory approval.14 Health and Nutrition Product Guide

TopicalsPVP-Iodine AntisepticPovidone iodine USP/NF, Ph. Eur., JPTopicalsAllantoin USPAllantoin USP/NF, Ph. Eur.DescriptionStable complex of iodine and polyvinylpyrrolidone (PVP)DescriptionGlyoxylidiureideAppearanceReddish-brown powderChemistryONCHCH 2I 3HCH 2ONCHCH 2NCHOAppearanceWhite, odorless crystalline powderChemistryOHN NOHNH C NH 2Active IngredientsProperties• Antiseptic agent• Available iodine of 11-12%• Releases iodine at levels balancing microbiocidal efficacy withreduced potential for irritation and sensitization often caused byhigher levels of free iodine on the site of application• No permanent staining of skin, natural fibers or hard surfaces• Virtually no vapor pressure or iodine sublimation• Water soluble• Compatible with most surfacesProperties• Classified “Safe and Effective” (Category 1) by the United StatesFood and Drug Administration (FDA) as a skin protectant at uselevels of 0.5-2.0%Applications and Benefits• Enhances the desirability of creams and lotions by its action as askin protectant• Approved by US FDA for many applications including minor cuts,scrapes, burns, sunburn, fever blisters, diaper rash and chaffed,chapped, cracked or wind-burned skin or lipsOApplications and Benefits• Safer and easier to use than classic iodine preparations• Disinfects skin for wound treatment, presurgical skinpreparation, and treatment of burn abrasions and infections onthe skin• Adheres to treated surfaces for prolonged activity• Forms films that protect wounds• Imparts effective antimicrobial activity to a wide range offormulations including powders, tablets, lotions, gels, ointments,creams and sprays• Reported effective in douches and vaginal suppositories fortreatment of vaginal infections• Produces effective gargles and presurgical oral washes and rinses• Reduces microbial levels in veterinary applications includingpresurgical scrubs, skin infection treatments and teat dips toprevent bovine mastitisHealth and Nutrition Product Guide 15

TopicalsCeraphyl® EmollientsTopicalsCerasynt® EmulsifiersTopical ExcipientsPatient compliance and consumer acceptance of pharmaceuticaltopical preparations may depend on their tactile properties. Manycommon formulations have poor product aesthetics which lead tolow patient compliance. Typically, combinations of emollients areutilized to provide a cascading sensory effect in which emollientswith various spreading rates are employed to eliminate sensorygaps from initial product application to residual after-feel. ISPoffers an extensive line of emollients to meet your formulationneeds. Below is a sampling of the products available and theirtypical applications. For additional information or for assistancein selecting the emollients to meet your formulation needs, pleasecontact your ISP sales office.Product Name Description Applications and BenefitsEsters Based on Alpha Hydroxy AcidsCeraphyl® 31 Lauryl lactate Lactate esters that deliver propertiesCsimilar to AHA derivatives withoutCeraphyl® 4112-15Alkyl lactatecausing irritation on the skinReduces tackiness and oiliness ofother components. Imparts non-oilyCeraphyl® 45 Dioctyl malatelubricity to hydro-alcoholic products.Easy to emulsify and works best atneutral pHLight Dry Feeling EstersISP offers oil-in-water emulsifiers for topical creams and lotions.ProductNameCerasynt®SDCerasynt®945Description Appearance HLBGlycerylStearateGlycerylStearateandLaureth-23MeltingPoint(ºC)Flake 3 55-57.5Flake 7-8 53-55ApplicationsNonionicstabilizer andemulsifier.Effectivenonionic acidstabilizedemulsifier fortopicalpreparations.Forms opaquegels withmineral oil.Ceraphyl® 140ACeraphyl® 230Isodecyl oleateDiisopropyladipateVery dry, non-greasy estersImparts a transient feel during rubout but leaves minimal residueafter-feelFrequently used to reduce thetackiness or light feel of heavieremollientsGeneral Purpose EstersCeraphyl® 368Esters that Impart BodyEmulsynt GDLEthylhexylpalmitateGlyceryldilaurateImparts “mild feel” to emulsionsduring rub-out and reducesintermediate tackiness.Less oily than mineral oil and has aricher feel than isopropyl myristateSolid emollient esters withmelting points slightly abovebody temperatureImparts dry, non-greasy after-feelUseful for adding “body” andviscosity to emulsions andincreasing eleganceEsters for Maximum After-FeelCeraphyl® 791Isocetyl stearoylStearateHighly branched di-esters that donot penetrate the skinDelivers a cushiony after-feel andprovides a long playtime16 Health and Nutrition Product Guide

TopicalsProlipid® 141 Lamellar Gel SystemTopicalsPreservativesDescriptionContains glyceryl stearate, behenyl alcohol, palmitic acid, stearicacid, lecithin, lauryl alcohol, myristyl alcohol and cetyl alcoholAppearanceCream-to-beige waxy flakesChemistryProperties• Lamellar gel formers that moisturize and promote healthy skin bystrengthening the skin’s natural barrier function• Possible to develop stable lamellar gel networks with a wide rangeof rheological and sensory properties• Compatible over wide pH range• Resistant to rinse-offApplications• Masks undesirable sensory properties, such as oily feel in topicalformulations• Overcomes poor patient compliance of topical formulations withoily ingredients by entrapping the oil phase within the bilayermatrix producing silky smooth feel• Provides excellent feel properties to medicated creams and bodywashesBased on a wealth of preservative expertise, ISP offers a range ofbroad-spectrum preservatives to meet the challenges of today’stopical formulations. Selecting the right preservative for yourproduct formulation is just as important as the other ingredientsand many factors will need to be considered. The guide belowwill aid in the selection of the ISP preservative. For additionalassistance, contact your local ISP sales office.Product Name Description Appearance ApplicationsGermall® 115Germall IIGermall PlusLiquidGermall PlusGermaben® IIGermaben II-ELiquaPar® OilLiquaPar PELiquaParOptimaImidazolidinylUreaImidurea, NFDiazolidinyl UreaDiazolidinylurea andIodopropynylButylcarbamatePropyleneGlycol andDiazolidinylUrea andIodopropynylButylcarbamatePropylene Glycoland DiazolidinylUrea andMethylparabenandPropylparabenPropylene Glycoland DiazolidinylUrea andMethylparabenandPropylparabenIsopropylparabenandIsobutylparabenand ButylparabenPhenoxyethanolandIsopropylparabenandIsobutylparabenand ButylparabenPhenoxyethanolandMethylparabenand IsopropylparabenandIsobutylparabenand ButylparabenWhitepowderWhitepowderWhitepowderClear liquidClear liquidClear liquidClear,viscousliquidClear,viscousliquidClear,viscousliquidLargelyanionicwater-solublesystemsLargelyanionicwater-solublesystemsLargelycationic andnonionicwater-solublesystems; Oilin wateremulsionsLargelycationic andnonionicwater-solublesystems;Oil in wateremulsionsOil in wateremulsionswith oil phase25%AnhydroussystemsAnhydroussystemsAnhydrousSystemsbased onmineral andnatural oilsTypicalUseLevel0.2-0.6%0.1-0.3%0.05-0.2%0.1%-0.5%0.5-1.0%0.5-1.0%0.4-0.8%0.5-1.0%0.5-1.0%Topical ExcipientsHealth and Nutrition Product Guide 17

Topicals · Medical DevicesGantrez® CopolymersBiomedical PolymersProduct Name Form AppearanceGantrez® S-96BF Solution STGantrez® S-97BFGantrez® S-97BF SolutionGantrez® MS-955Gantrez® ES-225Gantrez® ES-425Free acidof Gantrez®ANFree acidof Gantrez®ANFree acidof Gantrez®ANMixedsodium/calciumsaltHalf-esterderivativeHalf-esterderivativeSlightly hazy,viscousliquid(13% solids)Approx.MolecularWeightPowder 1,200,000Slightly hazy,viscousliquid(13% solids)White tooff-whitepowderViscousliquidViscousliquidBrookfieldViscosity(mPa. S)700,000 1501,500,0001,000,000100,000-150,00090,000-150,00070 (5%)340 (10%)1,000-1,600700-3,000(11.1%aqueoussolution)18,80014,400DescriptonCopolymers of polymethyl vinyl ether and maleic .anhydride (Gantrez AN) and derivativesProperties• Soluble in water and/or alcohol depending on the product form• Forms highly polar, tack-free films• Excellent wet adhesive strengths• BioadhesiveApplications and Benefits• Delivers excellent film-forming and adhesion properties to spraybandages and ostomy adhesives18 Health and Nutrition Product Guide

ISP Pharma TechnologiesISP Pharma Technologies (IPT) provides cGMP spray drying solutions to your drug solubility challenges.SolventAPIDispersant SystemMix/HomogenizeMixing Vessel(1)PumpPowderCollectionSpray DryBioavailability is enhanced by (1) dissolving the drug and a polymeric dispersant system in a suitable solvent, .(2) spray drying the resulting solution and (3) collecting the powder containing the drug either (A) molecularly .dispersed in the polymer matrix to form a solid solution or (B) dispersed as submicron particles to form a .solid suspension.In close collaboration, the ISP team will work with you through the entire commercialization process to enhance .the performance of your drug product:(2)(3)(a)Solid SolutionDrug Particle orDrug Rich LiquidSolid SuspensionSolid Emulsion(b)ISP Pharma Technologies• Feasibility Studies• Formulation/Process Development and Optimization• Scale-up• cGMP Clinical Supply Manufacturing• cGMP Commercial Production, the result is:—Enhanced bioavailability and therapeutic benefits—Reduced time to market—Improved life-cycle managementGetting StartedPlease contact your local ISP sales office or visit www.ispcorp.com to arrange a presentation to further describe .ISP Pharma technologies for drug solubilization.Health and Nutrition Product Guide 19

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While the information herein is believed to be reliable, we do not guarantee its accuracy and a purchaser must make its owndetermination of a product’s suitability for purchaser’s use, for the protection of the environment, and for the health and safety of its employees and the purchasers of its products. Neither ISP nor its affiliates shallbe responsible for the use of this information, or of any product, method, formulation, or apparatus described in this brochure. Nothing herein waives any of ISP’s or its affiliates’ conditions of sale, and WE MAKE NOWARRANTY, EXPRESS OR IMPLIED, OF MERCHANTABILITY OR FITNESS OF ANY PRODUCT FOR A PARTICULAR USE OR PURPOSE. We also make no warranty against infringement of any patents by reason of purchaser’suse of any information, product, method or apparatus described in this brochure.