Negative ion mode mass spectrometry - Journal of Chemical ...
Negative ion mode mass spectrometry - Journal of Chemical ...
Negative ion mode mass spectrometry - Journal of Chemical ...
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
<strong>Negative</strong> <strong>ion</strong>...Somsubhra Ghosh et al.(b) It is an accurate method for the determinat<strong>ion</strong> <strong>of</strong> molecular <strong>mass</strong> <strong>of</strong> the components and its elementalcomposit<strong>ion</strong>.(c) It also used to investigate react<strong>ion</strong> mixtures (gases, liquids and solids) and also used in understandingreact<strong>ion</strong> kinetics and mechanisms <strong>of</strong> unimolecular decomposit<strong>ion</strong> react<strong>ion</strong>s (16) .(d) Using solid phase extract<strong>ion</strong> (SPE) and liquid chromatography/tandem <strong>mass</strong> <strong>spectrometry</strong>(LC/MS/MS), 46 pesticides in positive <strong>ion</strong> <strong>mode</strong> and 14 pesticides in negative <strong>ion</strong> <strong>mode</strong> wereanalyzed (17) .(e) Sugar and sugar alcohols such as sorbitol and glucose were successfully analyzed by <strong>mass</strong><strong>spectrometry</strong> using atmospheric pressure <strong>ion</strong>izat<strong>ion</strong> in negative <strong>ion</strong> <strong>mode</strong> (18) .(g) ) ESI in the negative <strong>ion</strong> <strong>mode</strong> has been employed to determine the structure <strong>of</strong> glycosides <strong>of</strong>anthraquinones [67,68], coumarins [67], flavonoids [4,31,67,69,70], iridoids [67,71], aromatics [30,67],cardenolides [29],is<strong>of</strong>lavonoids [57] and triterpenes [67,72] (19) .(h) <strong>Chemical</strong> warfare agents, explosives, dyes are analyzed by using both positive and negative <strong>ion</strong> <strong>mode</strong>by using liquid chromatography-Mass <strong>spectrometry</strong> (20) .(i) By using negative chemical <strong>ion</strong>izat<strong>ion</strong> we can measure the MDA(3,4-Methylene dioxyamphetamine),MDMA(3,4-Methylene dioxy methamphetamine), MDEA(3,4-Methylene dioxy ethyl amphetamine) inblood (21) .CONCLUSIONMass spectrometer is operated in positive and negative <strong>ion</strong> <strong>mode</strong>. Generally now a days positive <strong>ion</strong> <strong>mode</strong>is used in many cases and <strong>Negative</strong> <strong>ion</strong> <strong>mode</strong> spectroscopy is also being used in some specific andsensitive cases, in such cases negative <strong>ion</strong> <strong>mode</strong> is more efficient than the positive <strong>ion</strong> <strong>mode</strong> .In future itcan be used in other fields also.REFERENCES(1) K. R. Jennings, Philosophical Transact<strong>ion</strong>s A., 1979,293:125-133.(2) D. Pavia, Spectroscopy, 2007, page no.401-419.(3) K. S Graham, Applicat<strong>ion</strong>s <strong>of</strong> liquid chromatography: Mass <strong>spectrometry</strong> to cytochromep450 inhibit<strong>ion</strong> screening and the measurement <strong>of</strong> plasma free Metanephrines, University<strong>of</strong> Wales Swansea 2005.(4) J. J. Pitt, Clin Biochem Rev, 2009, 30(1): 19-34.(5) Available at: http://www.colby.edu/chemistry/instruments/ElectrosprayIntro.pdf, Electrospray<strong>ion</strong> <strong>mass</strong> <strong>spectrometry</strong>.(6) D. F Smith, Petroleomics applicat<strong>ion</strong>s <strong>of</strong> fourier transform<strong>ion</strong> cyclotron resonance <strong>mass</strong><strong>spectrometry</strong>:Crude oil and bitumen analysis, The Florida state university college <strong>of</strong> artsand sciences, Oct, 2007.(7) K. A. Schug, Pseudo-molecular <strong>ion</strong> format<strong>ion</strong> by aromatic acids in negative <strong>ion</strong>izat<strong>ion</strong> <strong>mode</strong>electrospray <strong>ion</strong>izat<strong>ion</strong> <strong>mass</strong> <strong>spectrometry</strong>, Oct, 2002.(8) R. Ekman, J. Silberring, A. M.W. Brinkmalm, A. Kraj, D. M. Desiderio, N. M. Nibbering,1470 J. Chem. Bio. Phy. Sci. Sec. C, 2012, Vol.2, No.3, 1462-1471.
Change language