Gary Benson - Haematology Association of Ireland

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Treatment of Patients FailingPlatelet count: < 25–30,000/µlSplenectomyFirst-line Therapy• Rituximab• TPO agonist• Prednisone• Danazol/predSecond-line Therapy• Azathioprine•Oralcyclophosphamide• Mycophenolatemofetil• CyclosporineThird-line Therapy• High-dosecyclophosphamide• Combinationchemotherapy• Stem-cell transplantationAdapted from Cines DB, McMillan R. Annu Rev Med. 2005;56:425-442.
Wrapping it up…• ITP is often a chronic disease in adults• Multiple therapies may be needed overtime• Goal = prevention of complications• Therapy needs to be tailored to theindividual patient
Page 1 and 2: Overview of ITPDr Gary BensonDirect
Page 3: Statistics of ITP• Incidence of 2
Page 8 and 9: Aetiology of ITP : Children• Mate
Page 10 and 11: Diagnosis (of Exclusion)• Rule ou
Page 12 and 13: To Marrow or Not to Marrow?• Bone
Page 14 and 15: Management of ITP in Adults• Emer
Page 16 and 17: General Principles of Therapy• Ma
Page 18 and 19: When Planning Therapy…• Tailor
Page 20 and 21: Second-Line Therapy• IV Immune Gl
Page 22 and 23: Splenectomy• Usually reserved for
Page 24 and 25: Data from Fabris, F, et al. Br J Ha
Page 26 and 27: When all else fails…• Steroids
Page 28 and 29: Pathophysiology of ITPOAPOAutoantib
Page 30 and 31: Thrombopoietin Levels in ITP25025Pl
Page 32 and 33: Durable Responses in RomiplostimTri
Page 34 and 35: Eltrombopag and Median PlateletCoun
Page 36 and 37: Emergency Treatment of Adult ITP•

Gary Benson - Haematology Association of Ireland

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