Gary Benson - Haematology Association of Ireland

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Emergency Treatment <strong>of</strong> Adult ITP• IVIG (1.0 g/kg/d for 2–3 days) and/or• Methylprednisolone (1.0 g/d x 3d)• ± Platelet transfusion•±Factor VIIaCines DB, McMillan R. Annu Rev Med. 2005;56:425-442.
Initial Treatment <strong>of</strong> Adult ITPPlatelet count: > 25–30,000/µl• No treatmentPlatelet count: < 25–30,000/µl• Prednisolone (1 mg/kg/d PO) or• Periodic Anti-D (50–75 µg/kg IV as needed) or• Dexamethasone (40 mg/day x 4 days/month)Platelet count: < 25–30,000/µl• Immunization• Splenectomy• Rituximab• TPO agonistStable platelet count > 25–30,000/µl• No therapyAdapted from Cines DB, McMillan R. Annu Rev Med. 2005;56:425-442.
Page 1 and 2: Overview of ITPDr Gary BensonDirect
Page 3: Statistics of ITP• Incidence of 2
Page 8 and 9: Aetiology of ITP : Children• Mate
Page 10 and 11: Diagnosis (of Exclusion)• Rule ou
Page 12 and 13: To Marrow or Not to Marrow?• Bone
Page 14 and 15: Management of ITP in Adults• Emer
Page 16 and 17: General Principles of Therapy• Ma
Page 18 and 19: When Planning Therapy…• Tailor
Page 20 and 21: Second-Line Therapy• IV Immune Gl
Page 22 and 23: Splenectomy• Usually reserved for
Page 24 and 25: Data from Fabris, F, et al. Br J Ha
Page 26 and 27: When all else fails…• Steroids
Page 28 and 29: Pathophysiology of ITPOAPOAutoantib
Page 30 and 31: Thrombopoietin Levels in ITP25025Pl
Page 32 and 33: Durable Responses in RomiplostimTri
Page 34 and 35: Eltrombopag and Median PlateletCoun
Page 38 and 39: Treatment of Patients FailingPlatel

Gary Benson - Haematology Association of Ireland

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