Gary Benson - Haematology Association of Ireland

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General Principles <strong>of</strong> Therapy• Major bleeding rare if PLT > 10,000• Goal = get PLT count to safe level toprevent bleeding…•…not to specifically cure the ITP!
“Safe” Platelet Counts• “moderately” t-penic = 30-50,000• Probably safe if asymptomatic• Caution with elderly (CNS bleeds)
Page 1 and 2: Overview of ITPDr Gary BensonDirect
Page 3: Statistics of ITP• Incidence of 2
Page 8 and 9: Aetiology of ITP : Children• Mate
Page 10 and 11: Diagnosis (of Exclusion)• Rule ou
Page 12 and 13: To Marrow or Not to Marrow?• Bone
Page 14 and 15: Management of ITP in Adults• Emer
Page 18 and 19: When Planning Therapy…• Tailor
Page 20 and 21: Second-Line Therapy• IV Immune Gl
Page 22 and 23: Splenectomy• Usually reserved for
Page 24 and 25: Data from Fabris, F, et al. Br J Ha
Page 26 and 27: When all else fails…• Steroids
Page 28 and 29: Pathophysiology of ITPOAPOAutoantib
Page 30 and 31: Thrombopoietin Levels in ITP25025Pl
Page 32 and 33: Durable Responses in RomiplostimTri
Page 34 and 35: Eltrombopag and Median PlateletCoun
Page 36 and 37: Emergency Treatment of Adult ITP•
Page 38 and 39: Treatment of Patients FailingPlatel

Gary Benson - Haematology Association of Ireland

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