APTI ijopp - Indian Journal of Pharmacy Practice

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Indian J. Pharm. Pract. 1(2), Jan-Mar, 2009CONCLUSIONL-asparaginase studies of fibrinogen survival usingTreatment related to thrombotic complications during autologus 1-131fibrinogen. Blood 1970; 35:195-the induction therapy and recent evidence indicates that 200.concomitant administration of L-asparaginase is likely 8. Peterson RC, Handschumacher RF, Mitchell MS.to be associated with higher incidence of central venous Immunological responses to Lasparaginase. J Clinthrombosis, especially in children with atleast one Invest 1971; 50:1080-1090.prothrombotic risk factor. This result in prolongation of 9. Gugliotta L, Augelo A, Mattioli-Belmonte M,the prothrombin time (PT), activated partial Vigano-O'Angelo S, Colombo G, Catoni L, et al.thromboplastin time (aPTT) and hypofibrinogenimia. Hypercoagulability during L-asparaginaseThese coagulation abnormalities resolve within 1-2 treatment the effect of antithrombin IIIweeks after cessation of the drug.supplemantation in vivo. Br J Haematol 1990; 74At present, there is no general agreement on the need to (4):465-470.monitor the coagulation/fibrinolytic systems in patients 10. Kingma A, Tammnga RY, Kamps WA, Le-ceultre R,treated with L-asparaginase. There are also no Saan RJ. Cerebrovascular complications ofguidelines on ways to avoid either the haemorrhagic or L-asparaginase therapy in children with leukemia:the thrombotic complications. It is suggested to replace aphasia andother neuropsychological deficits.the coagulation factors with fresh frozen plasma and at Pediatr Hematol Onco1 1990; 10(4):303-309.the same time, give AT III and heparin; but the 11. AI-Mondhiry H. Hypofibrinogenemia associatedconsensus is to treat expectantly.with vincristine and prednisone therapy inACKNOWLEDGMENT lymphoblastic leukemia. Cancer 1975; 35:144-147The authors are thankful to Dr.Nalla G Palaniswami, 12. Ramsay NKC, Coccia PF, Krivit W, Nesbit ME,Chairman and Managing Director of Kovai Medical Edson JR. The effect of Lasparaginase on plasmaCenter and Hospital, Coimbatore and Dr.Thavamani D coagulation in acute lymphoblastic leukemia.Palaniswami, Trustee, Kovai Medical Center ResearchCancer 1977; 40:1398-1401.and Educational Trust, Coimbatore for providing 13. Kucuk 0, Kwaan HC, Gunnar W, Vazguez M.necessary facilities and continuous encouragement. Thromboembolic complications associated with L-REFERENCESasparaginase therapy. Cancer 1985; 55:702-706.1. Redaelli A, Laskin BL, Stephens JM, Botteman14. Priest JR, Ramsay NKC, Latcham RE, Lockman LA,MF, Pashos CL. A systematic literature review ofHasegawa DK, Coetes TD. Thrombotic andthe clinical and epidemiological burden of acutehemorrhagic strokes complicating early therapy forlymphoblastic leukaemia. Europ J Cancer Carechildhood acute lymphoblastic leukemia. Cancer2005; 14:53-62.1980; 46:1548-1554.2. Athale UH, Chan AKC. Thrombosis in children15. Priest JR, Ramsay NKC, Stemtarz PG, Tubergen DG,with acute lymphoblastic leukaemia:Cairo MS, Sitarz AL, etal. A syndrome of thrombosisepidemiology of thrombosis in children with acuteand hemorrhage complicating L-asparaginaselymphoblastic leukaemia. Thrombosis Res 2003;therapy for childhood acute lymphoblastic111:125-131.3. Capizzi RL, Bertmo JR, Handschumacher RE.leukemia. J Pediatr 1982; 100:984-989.16. Cairo MS, Lazarus K, Gilmare RL, Bachrur RL.L-asparaginase. Ann Rev Med 1970; 21:433.4. Keating MJ, Holmes R, Levuar S, Ho OH.Intracranial hemorrhage and focal seizuresL-asparaginase and PEG asparaginase past,secondary to use of L-asparaginase during inductionpresent, and future. Leuk lymphoma 1993; 10:153-therapy of acute lymphocytic leukemia. J Pediatr157.1980; 97:829-833.5. Haskell CM, Canellos GP, Leventhal BG, Carbore 17. Parma M, Belotti D, Pogliani-EM. Management ofPP, Block JP, Serpick AA, et al. L-asparaginase L-asparaginase induced prothrombotic state in acutetherapuetic and toxic effect in patient with lymphoblastic leukemia. Haematologica 1996;neoplastic disease. N Engl J Med 1969; 281:1028- 81(2):191.18. Celeste Lindley. Adverse effects of chemotherapy.1034.6. Oettgen HF, Stephanson PA, Schwatz ML, Leopar In: Koda-Kimble Mary Anne , Yee Young Lloyd ,RO, Fallal KR, Tan CC. Toxicity of Ecoli Kradjan Wayne A, Guglielmo Joseph B, AlldredgeL-asparaginase in man. Cancer 1970;25:153-278.Brian K, Corelli Robin L. Applied therapeutics: The7. Peterson RE, Himelstein ES, Oettgen HF and clinical use of drugs. Philadelphia: 2005; LippincottClifford GO. Hypofibrinogenemia due to Will ia ms & Wi lk ins:89- 95.84
Indian J. Pharm. Pract. 1(2), Jan-Mar, 2009INSTRUCTIONS TO AUTHORS -2009INDIAN JOURNAL OF PHARMACY PRACTICE (ijopp)Indian Journal of Pharmacy Practice (ijopp) is official numbered consecutively with arabic numbers, beginningjournal of Association of Pharmaceutical Teachers of with title page, ending with the (last) page of figureIndia (APTI). Indian Journal of Pharmacy Practice, a legends. The length of an Review/ Science Educationquarterly publication is devoted to publishing reviews article should not exceed 25 manuscript pages to includeand research articles in the area of Pharmacy Practice. figures, tables and references. No abbreviations orArticles in the areas of clinical pharmacy, hospital acronyms shall be used in the Title or Abstract acronyms,pharmacy, community pharmacy, pharmaceutical care, except for measurements. All the references, figurespharmacovigilance, pharmacoeconomics, clinical (Fig.) and tables (Table) in the text shall be numberedresearch, clinical pharmacokinetics and other related consecutively as they first appear. No sentence shall startissues can be sent for publication in ijopp. All with a numeral. Abbreviations like “&” and “etc” shall bemanuscripts should be submitted in triplicate along with avoided in the paper. There shall not be any decorative'Authorship Responsibility Undertaking', signed by all borders anywhere in the text including the title page. Thethe authors of the paper to,entire MS Word document with graphs and illustrationsThe Editor,pasted in it shall not exceed 2 MB. Manuscripts mustIndian Journal of Pharmacy Practice,Association of Pharmaceutical Teachers of India, conform to the “Uniform Requirements for ManuscriptsH.Q.: Al-Ameen College of Pharmacy, Hosur Road, Submitted to Biomedical Journals” http://www.icmje.org/.Opp. Lalbagh Main Gate, Bangalore- 560 027.The Content of the manuscript shall be organized in theAuthors should retain a copy of all materials submitted to following sequence and shall start on separate pages: titlethe journal; the editor cannot accept responsibility for page (including author's name, affiliations and addressloss or damage to submitted materials.for correspondence), abstract (including atleast 4 keyManuscripts will be subjected to peer review process to words), text (consisting of introduction, materials anddetermine their suitability for publication, provided they methods, results, discussion, conclusion andfulfilled the requirements of the journal. After the review, acknowledgements), references, figure legends, tablesmanuscript will be returned for revision along with and figures. Titles should be short, specific, and clear.reviewer's and /or editor's comments. One original copy Beginning with the first page of text, each page should beof the final revised manuscript should be submitted for consecutively numbered.publication within one month after receiving the For the Review Articles, the author(s) is absolutely freecomments. It is also desirable to submit the final revised to design the paper. The Abstract section is needed formanuscript on a CD prepared in MS word version 6.0/95 review articles too. The article should not exceed 15or a higher version.manuscript pages including figures, tables andSubmission of a manuscript to ijopp for publicationreferences. References, figures, and legends shall followimplies that the same work has not been eitherthe general guidelines described below. For all otherpublished or under consideration for publication inArticles, the following format shall be strictlyanother journal.followed.Author/s publishing results from in-vivo experimentsTitle Page. The following information should appear:involving animal or humans should state whether duetitle of article (A running title or short title of not morepermission for conduct of these experiments wasthan 50 characters), authors' name, and last name. Theobtained from the relevant authorities /Ethicsauthor to whom all correspondence be addressed shouldcommittee/Institutional Review Board.Manuscript preparation:be denoted by an asterisk mark. Full mailing address withManuscripts should be concisely typewritten in double pin-code numbers, phone and fax numbers, andspace in A4 sized sheets, only on one side with a 2 cm functional e-mail address should be provided of themargin on all sides. The manuscript shall be prepared in author for correspondence. Names of the authors shouldTimes New Roman font using a font size of 12. Title appear as initials followed by surnames for men and oneshall be in a font size 14. All section titles in the given-name followed by surname for women. Full namesmanuscript shall be in font size 12, bold face capitals. may be given in some instances to avoid confusion.Subtitles in each section shall be in font size 12, bold face Names should not be prefixed or suffixed by titles orlower case followed by a colon. The pages shall be degrees.85
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