APTI ijopp - Indian Journal of Pharmacy Practice

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Indian J. Pharm. Pract. 1(2), Jan-Mar, 2009Sanhita, Chakradatta and Nighandu Ratnakara which are simultaneously. Patients were encouraged to report anyof use in treating this condition.adverse reaction to the physician during the course ofCommon herbs such as Dhataki Flower, Musta, treatment.Mocharas, Lodhra, Lata Karanja have actions that RESULTS & DISCUSSIONinclude antifungal, antimicrobial, antiseptic, astringent, 36 patients completed the preliminary clinical study withand demulcents(13). Herbs with astringent activity may the polyherbal preparation (WH1). WH1 reduced theproduce a protective coating on the tissue surface. amount of vaginal discharge significantly in all theTherapeutically, these herbs may reduce irritation, patients both symptomatically and clinically. Significantinflammation, and excessive fluid secretion, and provide results were seen microbiologically in 30 patients (83%).a barrier against infection. Antiseptic and antimicrobial During the study period, 58 patients were enrolled; onlyherbs may work to eliminate bacterial and viral 36 patients completed the study. 22 patients wereinfections, and antifungal herbs may help fight fungal therefore excluded from the study as per the protocolinfections. A list of herbs containing these qualities for design. Hence, statistics of only 36 patients whothe treatment of vaginitis is shown in Table-1.completed the trial has been presented here and theTraditionally, a mixture of powder of the herbs listed inresults were summarized as percentages. Age of patientsTable-1 in the medium of ghee as “Anupana” [vehicle ofranged between 18 and 55 years (Fig.1) which explainsadministration] has been used effectively in the treatmentincidences of risk factors such as child birth, abortions,of vaginitis. However, there has been no documentationpassage of infective organism by infected semen etc inregarding its efficacy and safety.this age group (14). Maximum patients belonged to lowHence, the objective of this work was to take up apreliminary clinical study in a small patient group toincome group. Poor hygienic conditions, ignoranceconfirm the efficacy and safety of this poly herbalabout the proper cleaning and toilet habits and badpreparation (WH1). Therefore, this mixture of powdersnutritional status explains the higher incidence of thisin ghee base was formulated as soft gelatin capsules. The condition amongst this group (14). Duration offormula of this preparation is given in Table 2.complaints varied from less than 1 month (4 days) to 8METHODyears (Fig.2) which further confirms that women areInstitutional Ethical committee clearance was obtained busy in managing the household work without takingfrom Sri Sai Charitable Dispensary, Girinagar, Bangalore sufficient care regarding their own health. 25 patientsand Shreyas Poly Clinic & Laboratory, Chamarajpet, improved with the first course of 10 days treatmentBangalore, where the study was conducted for a period (69%). 7 patients received 2 courses of medicine and 2of six months, from November 2006 to April 2007. patients 3 courses of medicine. 2 patients received moreInformed consent was taken from all patients included inthan 4 courses of medicine without benefit (Fig.3). Thethe study after explaining to them the purpose of theetiology of patients observed by microbiologicalstudy.examination is given in (Fig.4). 17 patients wereInclusion Criteria: All patients presented withsymptoms of vaginitis at the clinic during the studydiagnosed as non specific vaginitis (47%), 14 asperiod of 6 months.Bacterial Vaginitis (39%), 3 as vaginal candidiasis (8%)Exclusion Criteria: Patients with white discharge due to and 1 each as atrophic vaginitis and senile vaginitis (3%).any other clinical condition like fibroid, malignancy etc The swabs taken after 15 days and after one month, whichand pregnant women.assessed the effectiveness of the treatmentAll patients who met the inclusion criteria were recruited microbiologically, showed 83% (30/36) patientsfor the study. These patients were clinically examined improved with treatment and no improvement was seenand a swab was taken from the vaginal discharge and sent in 17% (6/36) of patients (Fig.5). None of the patients into pathological laboratory. All patients were prescribed this series experienced any adverse reactions. Thus, thethe poly herbal formulation (WH 1) thrice a day for 10 polyherbal preparation (WH1) effectively produceddays after food. Two fortnightly follow ups were clinical and microbiological relief in women withconducted and progress was assessed by clinical vaginitis of varied etiology.improvements and confirmed by swab test. If the CONCLUSIONcondition was not improved, another course of treatment The polyherbal formulation (WH1) has shownwas repeated and the sexual partner also treated significant results in the treatment of vaginitis. But this70
Indian J. Pharm. Pract. 1(2), Jan-Mar, 2009Table -1: List of herbs used in the treatment of vaginitisList of herbs Botanical name Action & usesDhataki FlowerMustaMocharasLodhraLata KaranjaWoodfordia Floribunda flowerCyperus scariosus rootBombax malabaricum gumSymplecos recemosus rootCaesalpinia bonduc seedStimulant Astringent and Tonic used inleukorrhea, mennorhagiaPungent, Bitter, Astringent with Carminative,antibacterial, antifungal and Stimulatingproperties used in treatment of inflammation,tumor and infectionAstringent, tonic, demulcent, contains tannicacid and gallic acid. Used in dysentery,leukorrhea and menorrhagiaAstringent used in wound healing to reduce thebleeding, swelling and leukorrheaAntiseptic, Anti parasitic and Cleansing actionused in treatment of pain and skin diseasesTable -2: Formula of the soft gel capsules * .IngredientsExt. Dhataki FlowerExt MustaExt. MocharasPulv.LodhraPulv. Lata KaranjaGheeTotal weight of each capsuleQuantity/capsuleeq. to 20mgeq.to 40mgeq. to 22.5mg100mg50mgq.s650mg* Poly herbal formula code : (WH 1)Fig.1: Age distribution of patients in the study populationAge distribution of patients (yrs)41-5010%51-605%= 203%21-3038%= 2021-3031-4041-5051-6031-4044%71
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