APTI ijopp - Indian Journal of Pharmacy Practice

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Indian J. Pharm. Pract. 1(2), Jan-Mar, 20096. Kapoor B, Raina RK, Kapoor S. Drug prescribingpattern in a teaching hospital. Ind J Pharmacol 1985;17 (1):168.7. Pradhan SC, Shewade DG, Shashindran CH, BapnaJS. Drug utilization studies. National Med J India1988; 1:185.8. Bimo, Chowdhary A, Das A, Diwan V, Kafle KK,Mabadeje B. In: How to investigate drug use in healthfacilities (selected drug use indicator) actionprogramme on essential drugs. WHO officialpublication 1995;68.9. Tiwari H, Kumar A, Kulkarni SK. Prescriptionmonitoring of antihypertensive drug utilisation at thePanjab University Health Centre in India. OriginalArticle. Singapore Med J 2004; 45(3): 117.10. Mancia G, Grassi G. Antihypertensive treatment:past, present and future. J Hypertens 1998; 16:S1-7.11. Prisant LM, Beall SP, Nicholads GE, Feldman EB,Carr AA, Feldman DS. Biochemical, endocrine, andmineral effects of indapamide in black women. J ClinPharmacol 1990; 30:121-126.12. Hansson L. The place of beta-blockers in thetreatment of hypertension . Clin Exp Hypertens 1993;15:1257-1262.13. Chalmers J. The place of combination therapy in thetreatment of hypertension. Clin Exp Hypertens 1993;15:1299-1313.14. Alkhaja KA, Sequeira RP, Damanhori AH, MathurVS. Antihypertensive drug-associated sexualdysfunction: a prescription analysis-based study.Pharmacoepidemiol Drug Safe 2003; 12:203-212.68
Indian J. Pharm. Pract. 1(2), Jan-Mar, 2009APTIINTRODUCTIONVaginitis is described medically as an irritation and/orinflammation of the vagina. It is a very common diseaseaffecting millions of women each year. The three mostcommon vaginal infections reported each year arebacterial vaginosis (30-40%), candidiasis due to yeastinfection (20-25%) and trichomoniasis caused byprotozoal infection (15-20%). Vaginal infections canproduce a variety of symptoms, such as abnormal orincreased discharge, itching, fishy odor, irritation,painful urination or vaginal bleeding(1,2,3).Though the infections are not serious in nature, they canbecome chronic and the eradication of such infections isoften difficult. If left untreated, bacterial vaginosis mayresult in increased risk of pelvic inflammatory disease(PID), infertility, pre-term birth, premature rupture ofmembranes, low birth weight, intra-amniotic infections,endometritis, cervical intra-epithelial neoplasia (CIN),post-gynecological surgery infections and increased riskof sexually transmitted diseases (4,5).Indian Journal of Pharmacy PracticeReceived on 10/02/2009 Modified on 19/02/2009Accepted on 19/02/2009 © APTI All rights reservedijoppPreliminary Clinical Study of a Polyherbal Formulation (Wh1) inthe Treatment of Vaginitis1 2 34Vishnu Bapat *, Leena Alfred , Shobha Rani R.H , Pushpa. T. Ksheerasagar ,5 6Geetha Hegde , Soumya. K. Lund ,1. Vaidya Visharad, # 375 First B Main, First Phase, Girinagar, Bangalore 560 0852,3,6. Department of Pharmacy Practice, Al-Ameen College of Pharmacy, Bangalore.4. Retired Professor of Gynaecology, Bangalore Medical College, Bangalore.5. Shreyas Poly Clinic & Laboratory , Chamarajpet, Bangalore.*Address for correspondence: vrbapat@yahoo.co.inAbstractVaginitis is a very common disease affecting millions of women each year with multifactorial etiology. If leftuntreated it can lead to various complications. Current medical therapy may temporarily reduce infection but tendto disrupt the normal vaginal flora. Hence, herbal therapy is gaining popularity in women on account of its reducedside effects and restoration of the normal vaginal flora. With this in view, a preliminary clinical study was conductedusing a polyherbal formulation (WH I), containing herbs with antifungal, antibacterial, antiseptic and astringentproperties. In this prospective clinical study, 36 patients presented with the symptoms of vaginitis of varyingetiology were treated successfully with the polyherbal formulation (WH I) and was found to be safe and effective(83%). The results of this study were found to be significant, thus this study will be extended on a large patientpopulation in future.Key Words: Vaginitis, Polyherbal preparation (WH 1), Clinical Study, Female, bacterial vaginosis,candidiasis,richomoniasis, leucorrhoea.Vaginitis is identified by checking vaginal fluidappearance, vaginal pH and presence of volatile amines(the odor causing gas) and microscopic detection of cluecells 2 (6).Current medical therapy for vaginitis includes the use ofsystemic or topical antibiotic and antifungalpreparations. Vaginitis being a disorder of multifactorialetiology, a single-line therapy is often inadequate andrecurrence is a common complication. Though thesemedications may temporarily reduce infection, theyoften disrupt the balance of good bacteria and frequentlylead to recurrent infection. Studies shows thatvulvovaginal candiasis(VVC) affects three-quarters ofwomen during their lifetimes and use of antibiotics is anacknowledged trigger for VVC, which adversely affectswomen's physical and emotional health (7, 8, 9).Therefore, as an alternative to these medications herbaltherapy is gaining popularity in women on account of itsreduced side effects and restoration of the normal vaginalflora (10,11,12).Ayurvedic herbs are available, which have been listed inayurvedic literatures like Dhanwanthri Nighantu,Bhavaprakash Nighandu, Ashtanga Hrdaya, Sushruta69
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