CNS presentation of Lyme disease

Late stage neuroborreliosis• repeated IV antibiotic therapy for Lyme encephalopathy(persisting cognitive impairment after first treatment withceftriaxone)• B.A. Fallon et al. Neurology, 2008, 70 : 992-1003• A randomized, placebo-controlled trial : Ceftriaxone vs placebo IV• Patients with Improvement of cognitive impairment at week 12 but no sustainedeffect at week 24• Pain and physical function was improved at week 24 in group with more severe signs• Inclusion criteria based on presence of antibody (ELISA and Western Blot tests)• duration of antibiotic treatment in disseminated Lymeborreliosis• J. Oksi, Eur J Clin Microbiol Inf Dis, 2007 ; 26 : 571-581• double-blind, randomized, placebo-controlled,• oral adjunct antibiotics are not justified in the treatment of patientswith disseminated LB who initially receive intravenous ceftriaxone for 3weeks