CNS presentation of Lyme disease
CNS presentation of Lyme disease CNS presentation of Lyme disease
EUCALB case definitionClinical case definitionLaboratoryevidence: essentialLaboratory/clinicalevidence: supportingIn adultsmainly meningo-radiculitismeningitis, +/- facial palsyrarely encephalitis,myelitis;very rarely cerebralvasculitis.In childrenmainly meningitis and facialpalsy.CSFPleocytosisanddemonstration ofintrathecal specificantibody synthesisDetection of B.burgdorferi s.l. byculture and/or PCR fromCSF.Intrathecal synthesis oftotal IgM, and/or IgGand/or IgA.Specific serumantibodies. Recent orconcomitant EM
European national neurological societiesguidelines• Definite LNB.– The following three criteria are fulfilled:– neurological symptoms suggestive of LNB (with other causes excluded);– CSF pleocytosis;– Bb specific antibodies in CSF (produced intrathecally).• Possible LNB.– Two out of these three criteria are fulfilled.• If criterion III is lacking; after a duration of 6 weeks, there has to be found Bb-specific antibodies in theserum.• These criteria apply to all subclasses of LNB except for late LNB with polyneuropathy where the followingshould be fulfilled for definite diagnosis:– Peripheral neuropathy– Clinical diagnosis of ACA– Bb-Specific antibodies in serum..Mygland et al. Eur J Neurol, 2010 ; 17 : 8-16
- Page 5 and 6: The answer• If your referenceis
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- Page 10 and 11: Lyme diseasethe three steps of diag
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- Page 17 and 18: Symptoms of Lyme borreliosiskinetic
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- Page 21 and 22: Late neuroborreliosis• PNS manife
- Page 23 and 24: Neuroborreliosis an exemple in a re
- Page 25 and 26: Lyme diseasethe three steps of diag
- Page 27 and 28: Serology two-step approachScreening
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- Page 37 and 38: Doxyxyclin and neuroborreliosis•
- Page 39 and 40: Treatment of nervous system Lymedis
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- Page 48 and 49: Koch’s postulate• The microorga
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EUCALB case definitionClinical case definitionLaboratoryevidence: essentialLaboratory/clinicalevidence: supportingIn adultsmainly meningo-radiculitismeningitis, +/- facial palsyrarely encephalitis,myelitis;very rarely cerebralvasculitis.In childrenmainly meningitis and facialpalsy.CSFPleocytosisanddemonstration <strong>of</strong>intrathecal specificantibody synthesisDetection <strong>of</strong> B.burgdorferi s.l. byculture and/or PCR fromCSF.Intrathecal synthesis <strong>of</strong>total IgM, and/or IgGand/or IgA.Specific serumantibodies. Recent orconcomitant EM
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